Article
Biotechnology & Applied Microbiology
Yan Zhang, Lin Chen, Xuanting Ye, Zhixiong Wu, Zeyu Zhang, Biaofeng Sun, Hong Fu, Chuangang Fu, Xiaofei Liang, Hong Jiang
Summary: The study revealed that FRLnc1 in exosomes plays a role in promoting the growth and metastasis of gastric cancer by enhancing cell proliferation and migration. This suggests that FRLnc1 may serve as a potential biomarker for the diagnosis and treatment of gastric cancer, providing a new avenue for therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Angela L. Riffo-Campos, Javier Perez-Hernandez, Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Josep Redon, Raquel Cortes
Summary: This study identified different expression profiles of long non-coding RNAs (lncRNAs) associated with hypertension in plasma and plasma exosomes using next-generation sequencing. Analysis of gene ontology and KEGG pathways showed enrichment in biological functions related to albuminuria, providing insights into the mechanisms of albuminuria and cardiovascular damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hasan Ishtayeh, Hanna Achache, Eitan Kroizer, Yisrael Rappaport, Eyal Itskovits, Hila Gingold, Corinne Best, Oded Rechavi, Yonatan B. Tzur
Summary: Research has identified the involvement of certain lincRNAs in germ cell division processes in the nematode Caenorhabditis elegans, with linc-4 playing a crucial role in somatic growth. The findings suggest that some lincRNAs may be essential for germ-soma interactions.
Article
Genetics & Heredity
Ying Zhang, Wenjing Sun, Jing Bai, Songbin Fu, Kexian Dong
Summary: Drug resistance is a major challenge in cancer treatment, and long non-coding RNAs (lncRNAs) play a complex and precise regulatory role in regulating drug resistance in cancer. The common ways in which lncRNAs regulate drug resistance include ATP binding transporter overexpression, abnormal DNA damage response, tumor cell apoptosis, accumulation of epithelial mesenchymal transition, and cancer stem cell formation. Recent developments have focused on the role of exosomal lncRNAs in regulating cancer drug resistance. Further research into the role and mechanisms of lncRNAs in drug resistance in cancer will aid in improving clinical cancer treatment programs and exploring new treatment methods.
Article
Genetics & Heredity
Xianhui Zhang, Changjing Wang, Zhongxin Liu, Yuan Si
Summary: A risk model based on 11 MRlncRNAs was developed as an independent predictor of gastric cancer (GC) prognosis and may be useful in developing personalized treatment strategies for patients.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Mehrdad Hashemi, Shima Hajimazdarany, Chakrabhavi Dhananjaya Mohan, Maryam Mohammadi, Shamin Rezaei, Yeganeh Olyaee, Yeganeh Goldoost, Amin Ghorbani, Seyed Reza Mirmazloomi, Nazanin Gholinia, Amirabbas Kakavand, Shokooh Salimimoghadam, Yavuz Nuri Ertas, Kanchugarakoppal S. Rangappa, Afshin Taheriazam, Maliheh Entezari
Summary: Epithelial-to-mesenchymal transition (EMT) is an important event associated with embryogenesis, tumor progression, metastasis, and therapeutic resistance. This review comprehensively discusses the role and mechanism of action of long non-coding RNAs (lncRNAs) in regulating the EMT process in various cancers, as well as their involvement in the regulation of transcription factors and therapeutic response. The review also emphasizes the role of exosomal lncRNAs in the regulation of EMT, metastasis, and therapeutic response in cancers.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiaocong Lin, Guodan Li, Xiuwen Yan, Weiyu Fu, Jie Ruan, Hang Ding, Huajun Yu, Xiaoyi Chen, Liubo Lan, Yong Dai, Kai Pan, Xinguang Liu, Haitao Zhang
Summary: This study identifies lncRNA BC002811 as a critical regulator in the development and progression of gastric cancer. BC002811 is upregulated in GC tissues and cell lines and its high expression is associated with reduced overall survival in GC patients. BC002811 promotes GC cell proliferation, migration, invasion, and inhibits apoptosis in vitro, and accelerates tumor growth and metastasis in vivo. It upregulates MMP2 and MMP9 and promotes GC cell metastasis by downregulating PTEN expression and blocking SOX2 binding to the PTEN promoter.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Bingxian Bian, Li Li, Xing Ke, Hui Chen, Yi Liu, Naisheng Zheng, Yingxia Zheng, Yanhui Ma, Yunlan Zhou, Junyao Yang, Lanshu Xiao, Lisong Shen
Summary: Urinary exosomal long non-coding RNAs have been identified as potential noninvasive biomarkers for the diagnosis of bladder cancer through high-throughput RNA sequencing. A panel of genes has been established for the diagnosis of bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Ying Liu, Xiang Ao, Yu Wang, Xiaoge Li, Jianxun Wang
Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, and chemotherapy is an important treatment method. However, most patients develop resistance to chemotherapy drugs. Recent studies have found that lncRNAs are involved in gastric cancer drug resistance and they regulate drug resistance through various mechanisms. Some lncRNAs have potential clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yifan Li, Lan Lu, Xu Wu, Qianxiu Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Zhigui Wu, Wei Hu, Chi Hin Cho, Mingxing Li
Summary: This review summarizes the research progress on the roles of long non-coding RNAs (lncRNAs) in gastric cancer (GC), focusing on their involvement in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance, and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Review
Medicine, Research & Experimental
Bo Cao, Guoxiao Liu, Wang Zhang, Yajiao Shi, Bo Wei
Summary: Gastric cancer is a malignancy with high incidence and mortality rates globally, and non-coding RNAs, including circRNAs and lncRNAs, have been shown to play important roles in gastric carcinogenesis, serving as potential biomarkers for clinical diagnosis and prognosis. While significant progress has been made, there are still numerous issues to be addressed and further development is needed in this field.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ohanes Ashekyan, Samira Abdallah, Ayman Al Shoukari, Ghada Chamandi, Hayat Choubassy, Abdul Rahman S. Itani, Nisreen Alwan, Rihab Nasr
Summary: Breast cancer is the most common cancer type worldwide, and metastatic disease is the main cause of death. Non-coding RNAs found in exosomes have been found to play important roles in breast cancer progression, drug sensitivity/resistance, and have the potential to be used as diagnostic, prognostic, and predictive biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Lina Tingo, Emelie Ahlberg, Lovisa Johansson, Sindre Andre Pedersen, Konika Chawla, Pal Saetrom, Erika Cione, Melanie Rae Simpson
Summary: Breast milk contains a variety of RNA types, including miRNAs, with some miRNAs being widely reported across different fractions. It is currently challenging to determine which factors influence the characteristics of the miRNA profile, but studies suggest that certain miRNAs are highly expressed and stable in breast milk. Future research needs to further explore the biological effects of miRNAs in breast milk and characterize other ncRNAs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)