4.7 Article

pH-Responsive supramolecular DOX-dimer based on cucurbit[8]uril for selective drug release

期刊

CHINESE CHEMICAL LETTERS
卷 31, 期 5, 页码 1235-1238

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.10.020

关键词

Host-guest; Cucurbit[8]uril; pH-Responsive; Prodrug; Drug delivery

资金

  1. Science and Technology Development Fund, Macau SAR [030/2017/A1]
  2. University of Macau [MYRG2016-00008-ICMS-QRCM]
  3. National Natural Science Foundation of China [21871301]

向作者/读者索取更多资源

A supramolecular dimer of doxorubicin (DOX) was constructed via ternary host-guest interactions between cucurbit[8]uril (CB[8]) and tryptophan modified DOX (DOX-Trp, connected with an acid-labile bond) and we demonstrate for the first time that a supramolecular dimer of DOX can be formed upon homo-dimerization by CB[8], which may act as a stimuli pH-responsive, supramolecular DOX dimer prodrug system. This supramolecular DOX dimer transported DOX efficiently and selectively to cancer cells, thereby exhibiting significantly minimized cytotoxicity against noncancerous cells while maintaining effective cytotoxicity against cancer cells. Under this strategy, many other anticancer drugs could be chemically modified and loaded as a dimeric ammunition into CB[8] as supramolecular dimer prodrug systems (or a jet fighter) for improved cancer therapy. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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