期刊
CHEMICAL REVIEWS
卷 120, 期 1, 页码 5-35出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.9b00264
关键词
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资金
- National Institutes of Health [DC009100]
- CNRS [AFM 21805]
- Labex CelTisPhyBio [11-LBX-0038]
- IDEX PSL [ANR-10-IDEX-0001-02-PSL]
- [ANR-17-CE11-0029-01]
Generating force and movement is essential for the functions of cells and organisms. A variety of molecular motors that can move on tracks within cells have evolved to serve this role. How these motors interact with their tracks and how that, in turn, leads to the generation of force and movement is key to understanding the cellular roles that these motor-track systems serve. This review is focused on the best understood of these systems, which is the molecular motor myosin that moves on tracks of filamentous (F-) actin. The review highlights both the progress and the limits of our current understanding of how force generation can be controlled by F-actin-myosin interactions. What has emerged are insights they may serve as a framework for understanding the design principles of a number of types of molecular motors and their interactions with their tracks.
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