Article
Cell Biology
Zhigang Yi, Tao Ma, Jia Liu, Wenting Tie, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: This study found that LGR4 expression was significantly upregulated in multiple myeloma (MM) tissues and cells. Knockdown of LGR4 inhibited MM cell proliferation, promoted apoptosis and cell cycle arrest in G1, while overexpression showed the opposite effect. Mechanistic studies revealed that LGR4 could interact with TGF-beta 1 and activate the TGF-beta 1/Smad signaling pathway, promoting MM progression. LGR4 may be a potential new target for MM diagnosis and treatment.
CELLULAR SIGNALLING
(2023)
Review
Oncology
Reinofke A. J. van de Vis, Aristidis Moustakas, Lars P. van der Heide
Summary: TGF-beta signaling is crucial for regulating various cellular processes and is often implicated in tumor formation and progression. NUAK1 and NUAK2 play important roles in regulating TGF-beta signaling, enhancing or attenuating the cellular response to steer towards a specific output. Understanding the mechanisms of TGF-beta signaling and the role of NUAK kinases can provide insights into developing targeted therapies for TGF-beta-dependent diseases.
Article
Cell Biology
Hui Li, Hsun-Ming Chang, Yung-Ming Lin, Zhendan Shi, Peter C. K. Leung
Summary: This study suggests that TGF-beta 1 may upregulate the expression of SNAIL transcription factor, leading to a suppression of VCAM1 and ICAM1 in hGL cells, thereby inhibiting granulosa cell angiogenesis. The inhibitory effects of TGF-beta 1 on VCAM1 and ICAM1 expression may be mediated through an ALK5-dependent SMAD signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Integrative & Complementary Medicine
Kang Rong, Tian Wen, Cao Wei, Sun Yang, Zhang Hui-Nan, Feng Ying-Da, Li Chen, Li Ze-Zhi, Li Xiao-Qiang
Summary: LF delays liver fibrosis formation, decreases AST, ALT activities, and increases Alb activity in serum. It reduces oxidative damage, suppresses the TGF-beta/Smad signaling pathway, and plays a role in attenuating CCl4-induced liver fibrosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, Mayuko Ichimura, Koichi Tsuneyama, Koichi Matsuzaki, Toshiaki Nakano, Junko Hirohara, Toshihito Seki, Kazuichi Okazaki, M. Eric Gershwin, Makoto Naganuma
Summary: Patients with primary biliary cholangitis (PBC) are at higher risk for developing hepatocellular carcinoma (HCC), especially in the presence of comorbidities like excessive alcohol consumption. This study found that the balance of Smad signals may serve as a biomarker to predict the likelihood of HCC occurrence in PBC patients. Shifting favorably Smad phospho-isoforms through therapies could potentially reduce the risk of PBC-related HCC development.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Cell Biology
Jung-Chien Cheng, Lanlan Fang, Yang Yan, Jingyan He, Yanjie Guo, Qiongqiong Jia, Yibo Gao, Xiaoyu Han, Ying-Pu Sun
Summary: Estradiol, a main steroid hormone secreted by the ovaries, is crucial for maintaining normal female reproductive function；TGF-beta1 has been shown to stimulate aromatase expression and E2 production in ovarian granulosa cells through the involvement of SMAD2 and ERK1/2 signaling pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Piotr K. Zakrzewski
Summary: Endometrial cancer is a major gynecological cancer among women in their menopausal and postmenopausal age, and the canonical TGF beta pathway plays a crucial role in its development and progression. The TGF beta cascade can act as both a tumor suppressor and tumor promoter, with its effects on endometrial cancer cells depending on the cancer disease stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Senem Aykul, Jordan Maust, Vijayalakshmi Thamilselvan, Monique Floer, Erik Martinez-Hackert
Summary: The study revealed the significant regulatory role of TGF-beta family growth factors and inhibitors in adipocyte development, with SMAD1/5/8 signaling playing a crucial role in 3T3-L1 adipogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiying Liu, Nannan Qi, Wenwen Xing, Mengxuan Li, Yonghang Qian, Gang Luo, Shali Yu
Summary: The article translated introduces the regulatory role of the TGF-beta/SMAD signaling pathway in porcine follicular atresia and the important role of MORC2 in it. The results of the study reveal that MORC2 prevents porcine follicular atresia through the pathway involving mitochondrial apoptosis instead of DNA repair, and the TGF-beta/SMAD signaling pathway inhibits porcine granulosa cell apoptosis by up-regulating MORC2. SMAD4 is the transcription factor that regulates the expression of MORC2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Xuechun Sun, Yu Yang, Xiaodan Sun, Huali Meng, Wenhao Hao, Jialin Yin, Fuzhe Ma, Xin Guo, Lei Du, Lei Sun, Hao Wu
Summary: The current study investigated the preventive effect of krill oil (KO) on diabetic nephropathy (DN) and found that it can prevent DN by suppressing the TGF-beta 1 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang
Summary: GDF15 is a TGF beta-like cytokine that regulates target gene expression. TGF beta downregulates the expression of GDF15 through the activation of Smad signaling pathways. CAPE acts as an antagonist to block the effect of TGF beta on GDF15 expression.
Article
Oncology
Cuisong Tang, Dengpan Liang, Yuyou Qiu, Jingqi Zhu, Guangyu Tang
Summary: This study aimed to investigate the regulatory effects of omentin-1 on osteoblast viability and differentiation. The results showed that omentin-1 can significantly promote osteoblast viability and differentiation via the TGF-beta/Smad signaling pathway, thereby promoting bone formation and preventing osteoporosis.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yungai Xiang, Guo Yu, Yuxia Song, Yan Li, Lanlan Cheng, Pengfen Li, Le Zhang, Meng Wang, Li Tan
Summary: This study found that HAS2-AS1 is significantly upregulated in primary GCs from PCOS patients and positively correlated with HAS2 protein level. Knockdown of HAS2 restored the upregulation of HAS2-AS1 in promoting migration but not in promoting proliferation and repressing apoptosis. HAS2-AS1 represses TGF-beta signaling by inducing hypermethylation of the TGFBR2 promoter region.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Reproductive Biology
Sai-Jiao Li, Hsun-Ming Chang, Jeremy H. Wang, Jing Yang, Peter C. K. Leung
Summary: IL-6 trans-signaling modulates progesterone production by activating the phosphorylation of JAK2 and STAT3 in human granulosa-lutein cells.
BIOLOGY OF REPRODUCTION
(2022)
Article
Reproductive Biology
Faten AbdelHafez, Christian Klausen, Hua Zhu, Peter C. K. Leung
Summary: This study found that myostatin can increase trophoblast cell invasion by upregulating N-cadherin, and this effect is mediated by the SMAD2/3-SMAD4 signaling pathway.
BIOLOGY OF REPRODUCTION
(2022)
Editorial Material
Endocrinology & Metabolism
Yang Yu, Hsun-Ming Chang, John Even Schjenken
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Shen Tian, Han Zhang, Hsun-Ming Chang, Christian Klausen, He-Feng Huang, Min Jin, Peter C. K. Leung
Summary: Activin A increases the production of hyaluronan and the expression of versican in human granulosa-lutein cells, possibly through the mediation of the ALK4/SMAD2/SMAD3-SMAD4 signaling pathway.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Hsun-Ming Chang, Hua Zhu, Peter C. K. Leung
Summary: BMP2 suppresses PTX3 production through a canonical ALK2/3-mediated SMAD1/5-SMAD4-dependent signaling pathway, potentially regulating the process of endometrial decidualization in humans.
Article
Cell Biology
Hui Li, Hsun-Ming Chang, Saijiao Li, Christian Klausen, Zhendan Shi, Peter C. K. Leung
Summary: This study provides important insights into the molecular mechanisms by which AREG and TGF-β1 differentially regulate VE-cadherin expression and angiogenesis. AREG promotes microvascular-like formation through the EGFR-ERK1/2 signaling pathway, while TGF-β1 suppresses microvascular-like formation through the ALK5-SMAD2/3/4 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi Jiang, Ruolan Miao, Yuhuan Wang, Wenqi Wang, Dingying Zhao, Yue Niu, Qiaoqiao Ding, Yan Li, Peter C. K. Leung, Daimin Wei, Zi-Jiang Chen
Summary: Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder, which is the main cause of ovulatory obstacle associated with abnormal folliculogenesis. Dysfunction of ovarian granulosa cells (GCs) is recognized as a major factor that underlies abnormal follicle maturation. The expression of angiopoietin-like 4 (ANGPTL4) in GCs differs between patients with and without PCOS. In this study, ANGPTL4 was found to be upregulated in patients with PCOS and its overexpression inhibited the proliferation of GCs through the EGFR/JAK1/STAT3-mediated induction of p21, providing a novel epigenetic mechanism for the pathogenesis of PCOS.
Review
Endocrinology & Metabolism
Chia-Wei Chang, Yu-Wen Sung, Ya-Wen Hsueh, Yi-Yan Chen, Ming Ho, Hsi-Chen Hsu, Tung-Chuan Yang, Wu-Chou Lin, Hsun-Ming Chang
Summary: Growth hormone (GH) plays a critical role in regulating female reproductive functions, including ovarian development, oocyte maturation, and embryo implantation. GH deficiency can lead to reproductive pathologies and supplementation with GH can improve reproductive function and ART outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Xinyang Zhao, Siwen Zhang, Shan Gao, Hsun-Ming Chang, Peter C. K. Leung, Jichun Tan
Summary: Tissue engineering advancements allow modification of biomaterials for follicle development and hGC behavior. Hydrogels modified with laminin mimetic peptides in a 3D culture enhance follicle survival, growth, and viability. These peptides improve oocyte meiosis competence and regulate hGCs' biological activity through integrin alpha 6 beta 1 binding.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Jin Luo, Yaqin Wang, Hsun-Ming Chang, Hua Zhu, Jing Yang, Peter C. K. Leung
Summary: Recurrent pregnancy loss (RPL) is a problem in obstetrics and gynecology, and about 50% of cases remain unexplained. Unexplained RPL (uRPL) is believed to be linked to abnormal endometrial microenvironment. This study found that uRPL patients have lower levels of BMP2 and higher levels of ICAM1 in their endometrial samples. Further research using human endometrial stromal cells (HESCs) and human decidual stromal cells (HDSCs) revealed that BMP2 decreases ICAM1 expression by upregulating ID3 through the ALK3-SMAD4 signaling pathway. This study sheds light on a potential therapeutic target for uRPL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Xin Xin, Hsun-Ming Chang, Peter C. K. Leung, Li Dong, Jiaxi Li, Fang Lian, Haicui Wu
Summary: This study aimed to investigate the expression of PTX3 in granulosa lutein cells derived from women with PCOS and explore the potential regulation of BMP6 on PTX3 expression in hGL cells. The results showed that the levels of BMP6 were negatively correlated with oocyte maturation and embryo quality in PCOS, while the levels of PTX3 were positively correlated with oocyte maturation. In vitro experiments also confirmed that BMP6 inhibited the expression of PTX3 in KGN cells. Further analysis revealed that the ALK2/ALK3 type I receptors and BMPR2/ACVR2A type II receptors, as well as the SMAD1/5-SMAD4 signaling pathway, were involved in the suppressive effect of BMP6 on PTX3 in granulosa cells. These findings provide new insights into the pathogenesis of PCOS-related ovulatory disorders.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Obstetrics & Gynecology
Daimin Wei, Yaxin Su, Peter C. K. Leung, Yan Li, Zi-Jiang Chen
Summary: This review summarizes the current knowledge on the pathophysiological roles of BMPs and their underlying molecular mechanisms in regulating human endometrial proliferation and decidualization, aiming to promote the development of innovative strategies for diagnosing, treating, and preventing infertility and adverse pregnancy complications associated with dysregulated human endometrial remodeling.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
