期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 77, 期 8, 页码 1461-1481出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03329-5
关键词
Energy-converting hydrogenase; Hydrogenases; Energy conservation; Respiratory mechanism; Bioenergetics
资金
- Deutsche Forschungsgemeinschaft
- Claussen-Simon-Stiftung
The reversible interconversion of molecular hydrogen and protons is one of the most ancient microbial metabolic reactions and catalyzed by hydrogenases. A widespread yet largely enigmatic group comprises multisubunit [NiFe] hydrogenases, that directly couple H-2 metabolism to the electrochemical ion gradient across the membranes of bacteria and of archaea. These complexes are collectively referred to as energy-converting hydrogenases (Ech), as they reversibly transform redox energy into physicochemical energy. Redox energy is typically provided by a low potential electron donor such as reduced ferredoxin to fuel H-2 evolution and the establishment of a transmembrane electrochemical ion gradient (Delta(mu) over tilde (ion)). The Delta(mu) over tilde (ion) is then utilized by an ATP synthase for energy conservation by generating ATP. This review describes the modular structure/function of Ech complexes, focuses on insights into the energy-converting mechanisms, describes the evolutionary context and delves into the implications of relying on an Ech complex as respiratory enzyme for microbial metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据