Distinct functions of TMC channels: a comparative overview

Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells

(2019) Itallia V. Pacentine et al.   PLoS Genetics

Ultrastructural localization of the likely mechanoelectrical transduction channel protein, transmembrane-like channel 1 (TMC1) during development of cochlear hair cells

(2019) Shanthini Mahendrasingam et al.   Scientific Reports

Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc

(2019) Liping He et al.   CURRENT BIOLOGY

Proprioception

(2018) John C. Tuthill et al.   CURRENT BIOLOGY

TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans

(2018) Xiaomin Yue et al.   NEURON

Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases

(2018) Arturo Medrano-Soto et al.   PLoS One

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

(2018) Bifeng Pan et al.   NEURON

Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex

(2018) Christopher L. Cunningham et al.   Cold Spring Harbor Perspectives in Medicine

Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

(2018) Angela Ballesteros et al.   eLife

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells

(2018) David P. Corey et al.   Cold Spring Harbor Perspectives in Medicine

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

(2018) Sebastian Jojoa-Cruz et al.   eLife

A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish

(2017) Shih-Wei Chou et al.   Nature Communications

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

(2017) Christopher L Cunningham et al.   eLife

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

(2017) Timothy Erickson et al.   eLife

Is TMC1 the Hair Cell Mechanotransducer Channel?

(2016) Robert Fettiplace   BIOPHYSICAL JOURNAL

Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells

(2016) L. F. Corns et al.   JOURNAL OF NEUROSCIENCE

Exome sequencing identifies a mutation in TMC1 as a novel cause of autosomal recessive nonsyndromic hearing loss

(2016) Jiongjiong Hu et al.   Journal of Translational Medicine

Recessive mutations of TMC1 associated with moderate to severe hearing loss

(2016) Ayesha Imtiaz et al.   NEUROGENETICS

Sensing pH with TMCs

(2016) Christian Spalthoff et al.   NEURON

TMC-1 Mediates Alkaline Sensation in C. elegans through Nociceptive Neurons

(2016) Xiang Wang et al.   NEURON

The Basis of Food Texture Sensation in Drosophila

(2016) Yali V. Zhang et al.   NEURON

Transmembrane channel-like (tmc) gene regulatesDrosophilalarval locomotion

(2016) Yanmeng Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons

(2016) Andrew Lutas et al.   eLife

Targeted gene capture and massively parallel sequencing identifyTMC1as the causative gene in a six-generation Chinese family with autosomal dominant hearing loss

(2015) Xue Gao et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A novel mutation in the TMC1 gene causes non-syndromic hearing loss in a Moroccan family.

(2015) Amina Bakhchane et al.   GENE

Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohort

(2015) Guney Bademci et al.   GENETICS IN MEDICINE

The effects ofTmc1 Beethovenmutation on mechanotransducer channel function in cochlear hair cells

(2015) Maryline Beurg et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion

(2015) Shangbang Gao et al.   Nature Communications

TMC-1 attenuates C. elegans development and sexual behaviour in a chemically defined food environment

(2015) Liusuo Zhang et al.   Nature Communications

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

(2015) Kiyoto Kurima et al.   Cell Reports

Targeted Next-Generation Sequencing in Uyghur Families with Non-Syndromic Sensorineural Hearing Loss

(2015) Ying Chen et al.   PLoS One

Allelic heterogeneity among Iranian DFNB7/11 families: report of a new Iranian deaf family withTMC1mutation identified by next-generation sequencing

(2014) Elham Davoudi-Dehaghani et al.   ACTA OTO-LARYNGOLOGICA

Mutations in TMC1 are a Common Cause of DFNB7/11 Hearing Loss in the Iranian Population

(2014) Michael S. Hildebrand et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction

(2014) Hiroshi Nakanishi et al.   AURIS NASUS LARYNX

TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl− currents

(2014) Lalida Sirianant et al.   CELLULAR SIGNALLING

Autosomal recessive non-syndromic hearing loss is caused by novel compound heterozygous mutations in TMC1 from a Tibetan Chinese family

(2014) Fangzhu Lin et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2014) Bo Zhao et al.   NEURON

Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation

(2014) Yoshiyuki Kawashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Non-Syndromic Hearing Impairment in India: High Allelic Heterogeneity among Mutations in TMPRSS3, TMC1, USHIC, CDH23 and TMIE

(2014) Aparna Ganapathy et al.   PLoS One

Genetic Spectrum of Autosomal Recessive Non-Syndromic Hearing Loss in Pakistani Families

(2014) Sobia Shafique et al.   PLoS One

Whole Exome Sequencing Identifies New Causative Mutations in Tunisian Families with Non-Syndromic Deafness

(2014) Zied Riahi et al.   PLoS One

A Novel DFNA36 Mutation in TMC1 Orthologous to the Beethoven (Bth) Mouse Associated with Autosomal Dominant Hearing Loss in a Chinese Family

(2014) Yali Zhao et al.   PLoS One

Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

(2014) R. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sodium leak channel, NALCN, in health and disease

(2014) Maud Cochet-Bissuel et al.   Frontiers in Cellular Neuroscience

Gene Expression Profiling of Intrahepatic Cholangiocarcinoma

(2013) Ittisak Subrungruang et al.   Asian Pacific Journal of Cancer Prevention

The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels

(2013) Kyunghee X. Kim et al.   JOURNAL OF GENERAL PHYSIOLOGY

tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans

(2013) Marios Chatzigeorgiou et al.   NATURE

TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear

(2013) Bifeng Pan et al.   NEURON

NLF-1 Delivers a Sodium Leak Channel to Regulate Neuronal Excitability and Modulate Rhythmic Locomotion

(2013) Lin Xie et al.   NEURON

Genetic etiology study of the non-syndromic deafness in Chinese Hans by targeted next-generation sequencing

(2013) Tao Yang et al.   Orphanet Journal of Rare Diseases

Novel Compound Heterozygous TMC1 Mutations Associated with Autosomal Recessive Hearing Loss in a Chinese Family

(2013) Xue Gao et al.   PLoS One

A sensitive and specific diagnostic test for hearing loss using a microdroplet PCR-based approach and next generation sequencing

(2012) Isabelle Schrauwen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Identification of Three Novel Hearing Loss Mouse Strains with Mutations in the Tmc1 Gene

(2012) Shehnaaz S.M. Manji et al.   AMERICAN JOURNAL OF PATHOLOGY

TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2012) Wei Xiong et al.   CELL

Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins

(2012) Kyunghee X. Kim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Zebrafish Larvae Exhibit Rheotaxis and Can Escape a Continuous Suction Source Using Their Lateral Line

(2012) Julia Olszewski et al.   PLoS One

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

(2011) Yoshiyuki Kawashima et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families

(2011) Zippora Brownstein et al.   GENOME BIOLOGY

Progressive Sensorineural Hearing Loss and Normal Vestibular Function in a Dutch DFNB7/11 Family with a Novel Mutation in TMC1

(2010) Anne-Martine R. de Heer et al.   AUDIOLOGY AND NEURO-OTOLOGY

A novel mutation adjacent to theBthmouse mutation in theTMC1gene makes this mouse an excellent model of human deafness at the DFNA36 locus

(2010) T Yang et al.   CLINICAL GENETICS

Mechanosensitive Channels: In Touch with Piezo

(2010) Rui Xiao et al.   CURRENT BIOLOGY

Screening of 38 Genes Identifies Mutations in 62% of Families with Nonsyndromic Deafness in Turkey

(2010) Duygu Duman et al.   Genetic Testing and Molecular Biomarkers

Development and Regeneration of Sensory Transduction in Auditory Hair Cells Requires Functional Interaction Between Cadherin-23 and Protocadherin-15

(2010) A. Lelli et al.   JOURNAL OF NEUROSCIENCE

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

Mutation analysis of TMC1 identifies four new mutations and suggests an additional deafness gene at loci DFNA36 and DFNB7/11

(2009) N Hilgert et al.   CLINICAL GENETICS

Anoctamin and transmembrane channel-like proteins are evolutionarily related

(2009) Hahn   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mutations in TMC1 contribute significantly to nonsyndromic autosomal recessive sensorineural hearing loss: A report of five novel mutations

(2009) Aslı Sırmacı et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE

The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish

(2009) Michelle R. Gleason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMC1 but Not TMC2 Is Responsible for Autosomal Recessive Nonsyndromic Hearing Impairment in Tunisian Families

(2008) Abdelaziz Tlili et al.   AUDIOLOGY AND NEURO-OTOLOGY