Article
Biochemistry & Molecular Biology
Haijuan Jing, Chuan Wang, Liang Zhao, Jing Cheng, Pengyu Qin, Hongqi Lin
Summary: This study found that propofol plays a protective role in ameliorating myocardial ischemia-reperfusion injury by modulating the MALAT1/miR-206/ATG3 axis. Propofol pretreatment reduced markers of cardiac injury, suppressed apoptosis, and altered the expression of key genes involved in autophagy, ultimately protecting cardiomyocytes from ischemia-reperfusion injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Juan Xiang, Yuan-Yuan Deng, Hui-Xia Liu, Ying Pu
Summary: This study explored the mechanism by which long non-coding RNA (lncRNA) MALAT1 regulates nonalcoholic fatty liver disease (NAFLD). It was found that MALAT1 is up-regulated in NAFLD and its knockdown suppressed lipid accumulation in hepatocytes induced by free fatty acids. MALAT1 regulates hepatic lipid accumulation in NAFLD through the miR-206/ARNT axis, which in turn affects the expression of PPAR alpha/CD36. Therefore, MALAT1 may serve as a potential therapeutic target against NAFLD.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Limin Zhang, Xueyan Bai, Wenpeng Yan
Summary: In neonatal bronchopulmonary dysplasia (BPD), MALAT1 is up-regulated and targeted to miR-206, playing a regulatory role in the BPD process. The MALAT1-miR-206 axis may serve as a novel therapeutic target for neonatal BPD treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Rucui Yu, Chaojie Hu, Jinhu Li, Zhihui Lu, Yang Zhou, Fengqiong Wu, Yan Zhang
Summary: This study investigated the role of MALAT1/miR-206 in high glucose-induced inflammation, oxidative stress, and cell death of renal tubular epithelial cells. The results demonstrated that up-regulation of MALAT1 can reverse the inhibition of miR-206 on pyroptosis and inflammatory response, providing a potential target for treating DN in the clinic.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li, Zhiwen Zhang
Summary: The study found that high expression of miR-206 in patients with OA was positively correlated with peripheral Th17/Treg imbalance. MiR-206 disrupted the Th17/Treg balance by targeting SOCS3 and Foxp3. In vivo experiments showed that antagomiR against miR-206 restored the Th17/Treg balance during the development of OA.
MOLECULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Jinggang Li, Xiaofei Guan, Chongyun Xu, Jingyun Jia, Ling Zhang, Hui Han
Summary: This study found that miR-206 is downregulated in EM and miR-206 mimic inhibits cell proliferation, migration, and invasion while promoting cell apoptosis in EM. Furthermore, miR-206 inhibits tumor growth in vivo. Additionally, MALAT1 is upregulated in EM and is indicated to be a target of miR-206.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Qin Li, Shuo Li, Jin Ding, Bo Pang, Ranran Li, Hui Cao, Li Ling
Summary: A study found that the proliferation of trophoblasts in early-onset preeclampsia (ePE) is regulated by lncRNA MALAT1. The level of MALAT1 was decreased in placental tissue samples from ePE patients, and it was positively correlated with neonate birth-weight. Knockdown of MALAT1 inhibited trophoblast cell growth and migration, and promoted cell apoptosis. Moreover, MALAT1 reduction affected cell proliferation and growth through the regulation of miR-101-3p and VEGFA.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Oncology
Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia, Tarik Regad, Vincenzo Desiderio
Summary: This study found that MALAT1 expression is associated with high Gleason grade, metastasis occurrence, and reduced survival in PCa patients. The study also revealed a direct interaction between miR-423-5p and MALAT1, which inhibits MALAT1's activity and suppresses cell proliferation, migration, and invasion in PCa.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Orthopedics
Peng Zhou, Peng Xu, Wantao Yu, Huan Li
Summary: Our study found that miR-206 reduces the level of inflammatory factors, inhibits NP cell apoptosis, and increases extracellular matrix by targeting GJA1. miR-206/GJA1 may be potential therapeutic targets for IDD.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Physiology
Chrystalla Mytidou, Andrie Koutsoulidou, Margarita Zachariou, Marianna Prokopi, Konstantinos Kapnisis, George M. Spyrou, Andreas Anayiotos, Leonidas A. Phylactou
Summary: The study revealed that the expression of the four myomiRs in skeletal muscle tissues of mice changed with age, with miR-1, miR-133a, and miR-133b increasing rapidly before adolescence, while miR-206 decreased in all muscles. Furthermore, levels of miR-1, miR-133a, and miR-133b in muscle-derived exosomes peaked before early adolescence.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ailma O. da Paixao, Anaysa Paola Bolin, Joao G. Silvestre, Alice Cristina Rodrigues
Summary: The saturated fatty acid palmitic acid negatively affects muscle tube diameter, fusion, and metabolism, which may be related to miR-206.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Zhiyuan Lu, Dawei Wang, Xuming Wang, Jilong Zou, Jiabing Sun, Zhenggang Bi
Summary: Studies have shown that miR-206 plays a significant role in osteoporosis, with its serum level closely associated with bone density, making it a potential diagnostic biomarker. It can regulate osteoblast cell proliferation and apoptosis by targeting HDAC4.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ramesh Chaudhari, Simran Nasra, Nikita Meghani, Ashutosh Kumar
Summary: MicroRNAs play important roles in various diseases, including cancer. They can act as tumor suppressors or oncogenes, and their expression levels vary depending on cancer subtypes and mutations. Modified metallic nanoparticles can be used for effective miRNA delivery.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yingzhi Gu, Yuxing Bai
Summary: This study aimed to determine whether lncRNA MALAT1 promotes the osteogenic differentiation of human PDLSCs in vitro. The results showed that MALAT1 regulates human PDLSC differentiation by regulating the miR-93-5p/SMAD5 axis.
Article
Neurosciences
Lunpan Mou, Liyan Liao, Yaping Zhang, Desong Ming, Jianjia Jiang
Summary: Ursolic acid (UA) has anti-inflammatory and anti-oxidative effects. The study showed that UA can alleviate the damage of Nthy-ori 3-1 cells induced by IL-1 beta by mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappa B signaling pathway, suggesting its potential for AIT treatment.
PSYCHOPHARMACOLOGY
(2021)