Review
Chemistry, Medicinal
Adrian Mor, Anna Tankiewicz-Kwedlo, Dariusz Pawlak
Summary: Malignancies pose a significant public health challenge, with tumors developing mechanisms to evade treatment responses. The accumulation of tryptophan metabolites in the kynurenine pathway enhances neoplastic progression by suppressing the immune system's response, highlighting the potential for targeting this pathway in anticancer therapy. Various preclinical and clinical studies have been conducted on inhibiting enzymes in this pathway, showing promising results.
Review
Medicine, Research & Experimental
Chen Yang, Nanni Hua, Shufang Xie, Yi Wu, Lifeng Zhu, Shibing Wang, Xiangmin Tong
Summary: The incidence of hematological malignancies is on the rise, presenting major challenges such as poor prognosis in elderly patients, recurrence, and high mortality rates. Oncolytic viruses are recognized as an appealing approach for combating cancers, with strategies combining immunotherapy showing promise. Clinical trials involving oncolytic reovirus with immunotherapy drugs in multiple myeloma and preclinical studies combining oncolytic viruses with CAR-T cells are underway, indicating potential for a new, effective treatment approach for hematological malignancies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Zhenling Guo, Sanfang Tu, Siyao Yu, Liufang Wu, Wanying Pan, Ning Chang, Xuan Zhou, Chaoyang Song, Yuhua Li, Yanjie He
Summary: CD19-specific CAR T-cell therapy has shown significant efficacy in treating B-cell hematological malignancies, but targeted antigen-negative relapse poses a challenge to its widespread application. Researchers have explored alternative targets and tested combination antigen CAR T-cell therapies to enhance treatment effectiveness.
Article
Health Care Sciences & Services
Shiran Shapira, Dina Kazanov, Fatin Mdah, Hadas Yaakobi, Yair Herishanu, Chava Perry, Irit Avivi, Gilad Itchaki, Adi Shacham-Abulafia, Pia Raanani, Mori Hay-Levy, Gal Aiger, Jacob Mashiah, Shahar Lev-Ari, Nadir Arber
Summary: The study evaluated the sensitivity and specificity of a CD24/CD11b blood test for detecting hematological malignancies, revealing promising potential as a screening tool for these types of cancers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cell Biology
Narges Dastmalchi, Behzad Baradaran, Seyed Mahdi Banan Khojasteh, Mohammadali Hosseinpourfeizi, Reza Safaralizadeh
Summary: miR-424 is an endogenous miRNA with both tumor-suppressive and oncogenic characteristics, regulating important molecular pathways in cancer development. Its ability to modulate cellular processes makes it a potential diagnostic and therapeutic candidate for various types of cancers.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Alba Azagra, Cesar Cobaleda
Summary: Alterations in the epigenetic machinery play a critical role in cancer development and maintenance. H3K36 dimethylation, a common epigenetic mark, is mainly carried out by proteins of the NSD family, with NSD2 playing a key role in normal hematopoietic development. However, NSD2 is frequently altered in various types of tumors, especially hematological malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Karolina Golabek, Dorota Hudy, Agata Swietek, Jadwiga Gazdzicka, Natalia Dabrowska, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study analyzed the expression of E2F2 gene and protein, as well as the miRNAs candidate targets (miR-125b-5p, miR-155-3p, and miR-214-5p) in oral squamous cell carcinoma (OSCC) tumor and margin samples. The results showed that E2F2 gene is not the target for analyzed miRNAs in OSCC, while miR-155-3p and miR-125b-5p may play roles in the pathogenesis of OSCC. Additionally, miRNAs expression in response to tobacco smoke and HPV status showed differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Shenhe Jin, Ye Zhang, Fengping Zhou, Xiaochang Chen, Jianpeng Sheng, Jin Zhang
Summary: TIGIT plays a role in immune regulation in tumors, and blocking it has shown significant therapeutic efficacy, especially when combined with PD-1 inhibition.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Carlotta C. Damanti, Enrico Gaffo, Federica Lovisa, Anna Garbin, Piero Di Battista, Ilaria Gallingani, Anna Tosato, Marta Pillon, Elisa Carraro, Maurizio Mascarin, Caterina Elia, Alessandra Biffi, Stefania Bortoluzzi, Lara Mussolin
Summary: Plasma exosomal miRNAs are promising biomarkers for cancer diagnosis, and miR-486-5p and miR-26a-5p were identified as stable reference miRNAs for normalization using qRT-PCR, with miR-26a-5p specifically highlighted as a reliable reference for studies on hematological malignancies.
Review
Oncology
Deeksha Mehtani, Niti Puri
Summary: Mast cells play a crucial role in tumor growth and survival, with potential implications for the treatment of hematological malignancies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Yu Dong, Hui Yan, Jinman Li, Lei Bei, Xingxing Shi, Yanli Zhu, Zhijin Xie, Ruihua Zhang, Shijin Jiang
Summary: This study discovered that miR-155-1 is significantly increased upon NDRV infection and promotes virus replication by inhibiting the production of type I interferon. It proposed a novel regulatory mechanism of miR-155-1 in NDRV replication and provides new insights for further research on prevention and treatment of this virus.
Review
Oncology
Chaofeng Liang, Shuxin Huang, Yujie Zhao, Shaohua Chen, Yangqiu Li
Summary: TOX is a transcriptional factor containing the highly conserved HMG-box region, involved in maintaining tumors and promoting T cell exhaustion. It plays an important role in lymphocytic malignancies and may serve as a potential immune biomarker and target in immunotherapy for hematological malignancies.
BIOMARKER RESEARCH
(2021)
Review
Oncology
Samantha Bruno, Andrea Ghelli Luserna di Rora, Roberta Napolitano, Simona Soverini, Giovanni Martinelli, Giorgia Simonetti
Summary: CDC20 plays an important role in regulating the cell cycle and its abnormal functionality has been associated with cancer development and poor survival. Recent studies have revealed additional functions of CDC20, including apoptosis regulation, stemness properties, and correlation with immune cell infiltration. Investigating the network of interacting proteins of CDC20 provides insight into its role in mitosis and beyond. Furthermore, CDC20 expression and its association with prognosis in hematological malignancies have attracted increasing attention.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Dilipkumar Pal, Khushboo Raj, Shyam Sundar Nandi, Surajit Sinha, Abhishek Mishra, Arijit Mondal, Ricardo Lagoa, Jack T. Burcher, Anupam Bishayee
Summary: Histone deacetylases (HDACs) and histone acetyltransferases (HATs) regulate DNA expression by removing or adding acetyl groups to histones, respectively. HDACis have shown promise in treating malignancies by boosting immune response and diminishing tumor immunity. Additional studies are needed to evaluate the efficacy of HDACis, such as anobinostat, vorinostat, and tricostatin A, as therapeutic agents in hematological malignancies.
Review
Biochemistry & Molecular Biology
Karina Maciak, Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak
Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)