Article
Chemistry, Medicinal
Shiyuan Chang, Xiaoyong Chen, Yifan Chen, Lijun You, Kseniya Hileuskaya
Summary: This study analyzed the structural properties and anti-inflammatory activity of purified fractions derived from UV/H2O2-degraded polysaccharides from Sargassum fusiforme. The results showed that two fractions with different monosaccharide compositions and morphological characteristics were obtained, and PT-0.5 exhibited better anti-inflammatory activity.
Article
Food Science & Technology
Xiaoyong Chen, Lijun You, Yongxuan Ma, Zhengang Zhao, Viktoryia Kulikouskaya
Summary: UV/H2O2 treatment can improve the physicochemical properties of Sargassum fusiforme polysaccharides, reduce their toxicity in cells, and enhance their anti-inflammatory activity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Jiarui Li, Zhuo Wang, Jianping Chen, Baozhen Luo, Xuehua Chen, Rui Li, Jialong Gao, Xiaofei Liu, Bingbing Song, Saiyi Zhong
Summary: This study aimed to investigate the in vitro antioxidant activity and protective effect of Sargassum fusiform polysaccharides (SFPS) against H2O2-induced injury in LO2 cells. The results showed that SFPS exhibited strong antioxidant activity and potential hepatoprotective effect.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Food Science & Technology
Wanzi Yao, Mengyuan Liu, Xiaoyong Chen, Lijun You, Yongxuan Ma, Kseniya Hileuskaya
Summary: In this study, a degraded purified fraction from Sargassum fusiforme polysaccharides (SFP), called DSFP, was produced by UV/H2O2 degradation and step gradient ethanol precipitation. DSFP showed improved protective effects against intestinal epithelial injury, promoting wound healing and cell migration. It also enhanced intestinal barrier function and attenuated intestinal inflammation.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Bingxue Lv, Jiahao Ren, Yang Chen, Siyu Guo, Minqian Wu, Lijun You
Summary: In this study, a polysaccharide-based hydrogel microsphere was prepared and its improved properties, including increased springiness, cohesiveness, thermal stability, and enhanced adsorption capacity for crystal violet dye, were demonstrated.
Article
Biochemistry & Molecular Biology
Xiaoyong Chen, Xiong Li, Dongxiao Sun-Waterhouse, Biyang Zhu, Lijun You, Kseniya Hileuskaya
Summary: The study demonstrated that degraded polysaccharides from Sargassum fusiforme could ameliorate colitis by reducing inflammation, protecting the intestinal barrier, and modulating gut microbiota, potentially providing a basis for developing bioactive polysaccharides through free radical degradation.
Article
Biotechnology & Applied Microbiology
Ying Yang, Dan Ouyang, Jiayao Song, Chunyang Chen, Chenjing Yin, Laijin Su, Mingjiang Wu
Summary: This study found that fermentation by Lactobacillus has significant effects on the physicochemical properties and biological activities of Sargassum fusiforme polysaccharides (SFPs), providing a potential approach for improving the biological activity of polysaccharides.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Mengqing Zhang, Zhenna Zhang, Lichun Guo, Wei Zhao
Summary: In this study, subcritical water treatment was used to degrade Sargassum fusiforme polysaccharides and enhance their functional activity. The results showed that the treatment reduced the molecular weight of the polysaccharides and changed their composition, but did not significantly alter their functional groups. The degraded polysaccharides displayed better alpha-glucosidase inhibitory activity than acarbose. This research provides scientific evidence for the use of subcritical water treatment as a green and efficient method for preparing bioactive polysaccharides with low molecular weight.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Tian Wang, Hongying Zhao, Yongguang Bi, Xiaodan Fan
Summary: This study optimized the extraction conditions of Sargassum fusiforme polysaccharides using the response surface method, and successfully prepared SFPS-functionalized nanoselenium. The SFPS-SeNPs showed higher dispersion and stability compared to naked SeNPs, and the SFPS modifier significantly improved the free radical scavenging activity of SeNPs.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Chemistry, Medicinal
Wanzi Yao, Jiayu Yong, Bingxue Lv, Siyu Guo, Lijun You, Peter Chi-Keung Cheung, Viktoryia I. Kulikouskaya
Summary: In this study, UV/H2O2 treatment was used to prepare low-molecular-weight seaweed polysaccharides from Sargassum fusiforme. The treatment effectively degraded the polysaccharides and improved their anti-photoaging activity. UV/H2O2 treatment for 45 minutes showed the best anti-photoaging effect.
Article
Food Science & Technology
Hongying Zhao, Changjun Liu, Jiaxin Song, Xiaodan Fan
Summary: The stability and toxicity of selenium nanoparticles can be improved by decorating them with polysaccharides from Sargassum fusiforme (SFPS-SeNPs). Results from animal experiments showed that the median lethal dose of SFPS-SeNPs was 88.76 Se mg/kg, and the dose without observed adverse effects for 28 days was 4.43 mg Se/kg/day. Compared with Na2SeO3, SFPS-SeNPs may have slightly higher toxic effects, and they may accumulate in the liver when taken orally at a dose of 4.43 mg Se/kg/day. SFPS and nanotechnology can reduce the toxicity of selenium, and SFPS-SeNPs or SeNPs-polysaccharides can be used for drug delivery and food supplements.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Qifang Wu, Siya Wu, Yang Cheng, Zhongshan Zhang, Genxiang Mao, Shijun Li, Yue Yang, Xu Zhang, Mingjiang Wu, Haibin Tong
Summary: The study demonstrates that Sargassum fusiforme fucoidan (SFF) can significantly improve metabolic conditions and organ damage in T2DM mice, potentially by enriching beneficial gut microbiota and increasing levels of (R)-carnitine and choline in the colon to alleviate the disease symptoms.
Article
Chemistry, Medicinal
Bin Wei, Qiao-Li Xu, Bo Zhang, Tao-Shun Zhou, Song-Ze Ke, Si-Jia Wang, Bin Wu, Xue-Wei Xu, Hong Wang
Summary: High-fat diet significantly alters the cecal and fecal microbiota in mice, while seaweed polysaccharides SfW and SfA can more effectively regulate cecal microbiota. This study provides important groundwork for seaweed polysaccharide-based gut microbiota regulators.
Article
Biochemistry & Molecular Biology
Qianwen Zheng, Rui-Bo Jia, Zhi-Rong Ou, Zhao-Rong Li, Mouming Zhao, Donghui Luo, Lianzhu Lin
Summary: The study analyzed Sargassum fusiforme polysaccharides extracted at different pH and ethanol concentrations, showing significant differences in physicochemical properties and functional activities, indicating potential hypoglycemic effects and highlighting the importance of extraction conditions on the structure and properties of SFPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Guanrong Feng, Duo Zhang, Chengcheng Peng, Mingjiang Wu, Pengpeng Xiao, Nan Li
Summary: This research found that S. fusiforme extract had anti-human adenovirus type 7 (HAdV7) activity in vitro, with the most effective ingredient being alginate. The time of addition assay showed inhibitory effects on all life stages of the virus. Additionally, the antiviral activity of alginate against HAdV7 infection may be closely related to the endoplasmic reticulum stress (ERS) pathway. These results suggest potential applications of S. fusiforme extracts in the prevention and treatment of HAdV infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Food Science & Technology
Wanzi Yao, Xiaoyong Chen, Xiong Li, Shiyuan Chang, Mouming Zhao, Lijun You
Summary: Photoaging is a complex process triggered by UV radiation, causing changes in skin appearance and function, ultimately leading to skin cancer. Non-starch polysaccharides from natural resources are believed to have anti-photoaging effects, but research on this topic is still limited.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Agronomy
Yujiao Yang, Rui Zheng, Pingling Zhang, Jing Wen, Yue Luo, Zhengang Zhao, Lijun You, Chi-Tang Ho
Summary: Sugarcane is rich in polyphenols, including quercetin, apigenin, luteolin, tricin, and p-coumaric acid, which have shown inhibitory effects against MCF-7 breast cancer cells. The combination of luteolin and p-coumaric acid exhibited synergistic effects at all tested concentrations, while luteolin combined with apigenin showed synergistic effects at high inhibition rates. synergistic relation among polyphenols present in sugarcane in inhibition of cancer cell growth.
Article
Chemistry, Applied
Zhengming Xu, Chengtao Wang, Huaifeng Yan, Zhengang Zhao, Lijun You, Chi-Tang Ho
Summary: This study investigated the color intensification of the major anthocyanin in sugarcane by phenolic acids/aldehydes, finding that temperature and concentration affected the color enhancement. Thermodynamic parameters and quantum chemical calculations showed that hydrogen bonds and van der Waals force interactions contributed to color. Pyranoanthocyanins derived from cyanidin-3-O-glucoside and phenolic acids were identified, with electron-donating substituents stabilizing the intermediate carbenium ion forming the final products.
Article
Food Science & Technology
Wanzi Yao, Mengyuan Liu, Xiaoyong Chen, Lijun You, Yongxuan Ma, Kseniya Hileuskaya
Summary: In this study, a degraded purified fraction from Sargassum fusiforme polysaccharides (SFP), called DSFP, was produced by UV/H2O2 degradation and step gradient ethanol precipitation. DSFP showed improved protective effects against intestinal epithelial injury, promoting wound healing and cell migration. It also enhanced intestinal barrier function and attenuated intestinal inflammation.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Applied
Wanzi Yao, Yufeng Gong, Laihao Li, Xiao Hu, Lijun You
Summary: Dietary fibers from rice bran and wheat bran can modulate gut microbiota, enhance intestinal barrier function, regulate the immune system, and play an important role in human health.
Article
Biochemistry & Molecular Biology
Bingxue Lv, Jiahao Ren, Yang Chen, Siyu Guo, Minqian Wu, Lijun You
Summary: In this study, a polysaccharide-based hydrogel microsphere was prepared and its improved properties, including increased springiness, cohesiveness, thermal stability, and enhanced adsorption capacity for crystal violet dye, were demonstrated.
Article
Biochemistry & Molecular Biology
Yifan Chen, Weixuan Huang, Yang Chen, Minqian Wu, Ruohan Jia, Lijun You
Summary: By degrading LJP with UV/H2O2, hydrogels with different molecular weights were produced for wound dressings with excellent anti-inflammatory activity and swelling property. Low Mw LJP-based hydrogels showed great potential for wound dressing application.
Article
Chemistry, Medicinal
Mengfen Wei, Huamai Qiu, Jie Zhou, Chenghao Yang, Yifan Chen, Lijun You
Summary: Peptides from Pinctada martensii meat have anti-photoaging activities by increasing cell viability and reducing the levels of specific enzymes. Some identified peptides, such as Phe-His (FH), effectively reduce the levels of specific enzymes through molecular docking analysis and show potential as anti-photoaging agents.
Article
Agriculture, Multidisciplinary
Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao
Summary: To improve the liposolubility and bioavailability of phenolic glycosides, highly liposoluble derivatives were efficiently synthesized. These derivatives exhibited high log P values and retained good antioxidant activity, making them potential alternatives to BHT and TBHQ in lipid systems.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhou, Mengfen Wei, Lijun You
Summary: In this study, peptides from Pinctada martensii meat were prepared and the structures were identified. The potential antioxidant peptides were synthesized and their activities were verified using HepG2 cells. The results showed that the peptides exhibited antioxidant effects and could be used as candidates in functional foods.
Article
Chemistry, Medicinal
Shiyuan Chang, Xiaoyong Chen, Yifan Chen, Lijun You, Kseniya Hileuskaya
Summary: This study analyzed the structural properties and anti-inflammatory activity of purified fractions derived from UV/H2O2-degraded polysaccharides from Sargassum fusiforme. The results showed that two fractions with different monosaccharide compositions and morphological characteristics were obtained, and PT-0.5 exhibited better anti-inflammatory activity.
Article
Chemistry, Medicinal
Wanzi Yao, Jiayu Yong, Bingxue Lv, Siyu Guo, Lijun You, Peter Chi-Keung Cheung, Viktoryia I. Kulikouskaya
Summary: In this study, UV/H2O2 treatment was used to prepare low-molecular-weight seaweed polysaccharides from Sargassum fusiforme. The treatment effectively degraded the polysaccharides and improved their anti-photoaging activity. UV/H2O2 treatment for 45 minutes showed the best anti-photoaging effect.
Editorial Material
Food Science & Technology
Wanzi Yao, Qiuhong Kong, Lijun You, Saiyi Zhong, Kseniya Hileuskaya
Summary: The intestinal barrier is vital for maintaining gut homeostasis and overall health. Dysfunction of the intestinal barrier is linked to various diseases such as inflammatory bowel disease and colorectal cancer. This review focuses on the physicochemical properties of three main types of brown seaweed polysaccharides (BSP), their absorption and metabolism in the intestine, and their impact on the intestinal barrier. BSP are not directly digested in the upper gastrointestinal tract but can be utilized through fermentation by gut microbiota. They improve intestinal integrity, reduce tight junction dysfunction and intestinal permeability, and promote the production of beneficial metabolites. This review highlights the potential of BSP derived from brown seaweed as a natural and effective approach for preventing and treating intestinal diseases.
Article
Chemistry, Applied
Aliaksandr Kraskouski, Kseniya Hileuskaya, Viktoryia Nikalaichuk, Alena Ladutska, Volha Kabanava, Wanzi Yao, Lijun You
Summary: New chitosan derivatives were obtained by hydrothermal treatment and characterized using various physical and spectroscopic methods. The hydrothermal treatment resulted in a significant decrease in molecular weight and increased antiradical and antimicrobial activities of the derivatives.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
