Article
Endocrinology & Metabolism
Tian Feng, Toru Yamashita, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Nozomi Hishikawa, Koji Abe
Summary: This study investigated the potential therapeutic effect of the free radical scavenger edaravone on white matter lesions in a mouse model of Alzheimer's disease with chronic hypoperfusion. The results showed that edaravone improved white matter integrity, enhanced oligodendrocyte proliferation, attenuated endothelium/astrocyte dysfunction, and reduced neuroinflammation and oxidative stress. These findings suggest that long-term administration of edaravone may be a promising therapeutic approach for cognitive deficits in Alzheimer's disease with chronic hypoperfusion.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, General & Internal
Dongyu Fan, Huiyun Li, Dongwan Chen, Yang Chen, Xu Yi, Heng Yang, Qianqian Shi, Fangyang Jiao, Yi Tang, Qiming Li, Fangyang Wang, Shunan Wang, Rongbing Jin, Fan Zeng, Yanjiang Wang
Summary: The study found no significant differences in cortical standard uptake ratios, grey/white ratio, and brain atrophy indices between hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion, suggesting that chronic hypoperfusion may not directly induce cerebral beta-amyloid deposition and neurodegeneration in humans due to large vessel stenosis.
CHINESE MEDICAL JOURNAL
(2022)
Article
Geriatrics & Gerontology
Min-Soo Kim, Jihye Bang, Bu-Yeo Kim, Won Kyung Jeon
Summary: This study revealed that chronic cerebral hypoperfusion can impair cognitive flexibility in 5XFAD mice, possibly involving Aβ clearance mechanisms.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Neurosciences
Tian Feng, Xinran Hu, Yusuke Fukui, Zhihong Bian, Yuting Bian, Hongming Sun, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Ryuta Morihara, Koji Abe, Toru Yamashita
Summary: The oral ingestion of scallop-derived plasmalogen (sPlas) has beneficial effects on cognitive function and cerebral blood flow in AD with CCH. It reduces protein deposition and neuroinflammation, improves oxidative stress, and inhibits neuronal loss.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yasuteru Inoue, Masayoshi Tasaki, Teruaki Masuda, Yohei Misumi, Toshiya Nomura, Yukio Ando, Mitsuharu Ueda
Summary: In this study, the researchers found that α-enolase (ENO1) can interact with amyloid beta (Aβ) and inhibit its fibril formation. They also demonstrated that ENO1 can disrupt Aβ fibrils and weaken their cytotoxic effects by degrading Aβ peptides. Additionally, infusion of ENO1 into mouse brains reduced cerebrovascular Aβ deposits and improved cognitive impairment. These findings suggest that ENO1 may be a therapeutic target in cerebral amyloid angiopathy (CAA).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Zhihong Bian, Xinran Hu, Xia Liu, Haibo Yu, Yuting Bian, Hongming Sun, Yusuke Fukui, Ryuta Morihara, Hiroyuki Ishiura, Toru Yamashita
Summary: Rivaroxaban can alleviate fibrinogen deposition and oxidative stress, enhance remyelination, thereby improving white matter integrity and reducing the risk of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Vaibhav Gurunathan, John Hamre, Dmitri K. Klimov, Mohsin Saleet Jafri
Summary: Alzheimer's disease, the most common form of dementia, currently has no cure. This study utilized machine learning techniques and molecular dynamics simulation data to explore the relationship between A beta torsion angles and disease measures. The research has the potential to help determine which specific residues of A beta should be targeted for drug development.
Review
Cell Biology
Xiaofang Xu, Huikang Xu, Zhaocai Zhang
Summary: Cerebral amyloid angiopathy (CAA) is a disease characterized by the deposition of amyloid beta (A beta) and other amyloid proteins in the brain's blood vessels, leading to cerebrovascular and brain damage. CAA is often associated with cardiac injury, involving A beta, tau, and transthyroxine amyloid (ATTR). A beta acts as the main damaging factor, causing coronary artery atherosclerosis, aortic valve calcification, and cardiomyocyte degeneration. The progression of CAA can further impact the heart through amyloidosis, inflammation, and cerebral hemorrhage. The interaction between CAA and cardiac injury creates a vicious cycle that accelerates the progression of both conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazare, Sergio Oddi, Mauro Maccarrone
Summary: Chronic exposure to beta-amyloid peptides (A beta) may modify the endocannabinoid signaling in microglial cells, leading to a pro-AD phenotype. A beta-exposed microglia produced more 2-arachidonoylglycerol (2-AG) and showed altered expression of enzymes and receptors involved in 2-AG synthesis and signaling. Enhanced 2-AG signaling may contribute to the pro-AD phenotype of microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Mo-Kyung Sin, Edward Zamrini, Ali Ahmed, Kwangsik Nho, Ihab Hajjar
Summary: Anti-amyloid therapies (AATs) are emerging treatments for early Alzheimer's disease (AD). However, they may cause abnormal signals in the brain, known as amyloid-related imaging abnormalities (ARIA). Cerebral amyloid angiopathy (CAA) is a major risk factor for ARIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tsuyoshi Hamaguchi, Kenjiro Ono, Masahito Yamada
Summary: Deposition of amyloid beta protein in the brain is a characteristic of Alzheimer's disease, which can be transmitted between individuals through a prion-like mechanism. Pathological studies have shown that patients with iatrogenic Creutzfeldt-Jakob disease, caused by medical procedures such as human growth hormone injection and dura mater graft, also have cerebral amyloid beta protein deposition. Additionally, young patients with cerebral amyloid angiopathy-related cerebral hemorrhage, who have undergone neurosurgeries with or without dura mater graft in early childhood, suggest that the transmission of cerebral amyloid beta protein pathology is often through amyloid angiopathy rather than parenchymal deposition.
NEUROCHEMICAL RESEARCH
(2022)
Review
Cell Biology
Mohamad Anuar Ahad, Nelson Jeng-Yeou Chear, Lim Gin Keat, Ahmad Tarmizi Che Has, Vikneswaran Murugaiyah, Zurina Hassan
Summary: The study aimed to investigate the neuroprotective effect of Clitoria ternatea root bioactive fraction (CTRF) in a rat model of chronic cerebral hypoperfusion (CCH). Results showed that CTRF, containing clitorienolactones A (CLA), significantly improved cognitive deficits and reversed the inhibition of neuroplasticity caused by CCH. Additionally, CTRF and CLA had a positive effect on the levels of amyloid-beta plaque and neurotransmitters.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Poul F. Hoilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Abass Alavi, Kasper P. Kepp, Stefano L. Sensi, George Perry, Nikolaos K. Robakis, Jorge R. Barrio, Bryce Vissel
Summary: The FDA's accelerated approval of aducanumab and lecanemab for Alzheimer's disease treatment has sparked intense debate. A review of randomized clinical trials with eight similar antibodies reveals uncertain clinical efficacy and potential therapy-related brain damage. Due to these uncertainties, the FDA should pause approvals and prioritize further studies on the risks and benefits of these drugs, including PET and MRI examinations.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada
Summary: The study found that exogenous A beta seeds from different A beta pathologies induced A beta deposition in the blood vessels rather than the brain parenchyma, which might be the predominant feature of A beta pathology in iatrogenic transmission cases; Contamination of brain tissues from patients with little A beta pathology could lead to iatrogenic transmission of A beta pathology, emphasizing the urgent need for the development of inactivation methods to prevent such transmission.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Medicine, General & Internal
Ryo Sasaki, Yasuyuki Ohta, Yoshiaki Takahashi, Keiichiro Tsunoda, Koh Tadokoro, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Tom Yamashita, Koji Abe
Letter
Clinical Neurology
Emi Nomura, Yasuyuki Ohta, Koh Tadokoro, Kota Sato, Ryo Sasaki, Yoshiaki Takahashi, Toru Yamashita, Mami Takemoto, Nozomi Hishikawa, Yu-ichi Goto, Koji Abe
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Article
Neurosciences
Kota Sato, Ryo Sasaki, Yasuyuki Ohta, Maori Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Article
Neurosciences
Xiaowen Shi, Yasuyuki Ohta, Xia Liu, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toni Yamashita, Koji Abe
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Clinical Neurology
Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Toru Yamashita, Jingwei Shang, Yumiko Nakano, Ryuta Morihara, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Xiaowen Shi, Yasuyuki Ohta, Xia Liu, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe
Article
Neurosciences
Emi Nomura, Yasuyuki Ohta, Koh Tadokoro, Jingwei Shang, Tian Feng, Xia Liu, Xiaowen Shi, Namiko Matsumoto, Ryo Sasaki, Keiichiro Tsunoda, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Koji Abe
Article
Medicine, General & Internal
Ryo Sasaki, Yasuyuki Ohta, Kota Sato, Koh Tadokoro, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hiroyuki Ishiura, Shoji Tsuji, Koji Abe
Article
Neurosciences
Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Ryuta Morihara, Yumiko Nakano, Yoshiaki Takahashi, Noriko Hatanaka, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Neurosciences
Koji Abe, Jinwei Shang, Xiaowen Shi, Toru hita Yamas, Nozomi Hishikawa, Mami Takemoto, Ryuta Morihara, Yumiko Nakano, Yasuyuki Ohta, Kentaro Deguchi, Masaki Ikeda, Yoshio Ikeda, Koichi Okamoto, Mikio Shoji, Masamitsu Takatama, Motohisa Kojo, Takeshi Kuroda, Kenjiro Ono, Noriyuki Kimura, Etsuro Matsubara, Yosuke Osakada, Yosuke Wakutani, Yoshiki Takao, Yasuto Higashi, Kyoichi Asada, Takehito Senga, Liang-Ja Lee, Kenji Tanaka
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Clinical Neurology
Yasuyuki Ohta, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yosuke Osakada, Mami Takemoto, Toru Yamashita, Yoshio Omote, Takeshi Ikeuchi, Koji Abe
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Letter
Clinical Neurology
Ryo Sasaki, Yasuyuki Ohta, Noriko Hatanaka, Koh Tadokoro, Emi Nomura, Jingwei Shang, Mami Takemoto, Nozomi Hishikaw, Toru Yamashita, Yoshio Omote, Eisaku Morimoto, Sanae Teshigawara, Jun Wada, Yu-ichi Goto, Koji Abe
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
