Article
Biotechnology & Applied Microbiology
Joel Oliveira Barreto, Francisca Bruna Stefany Aires do Nascimento, Said Goncalves da Cruz Fonseca, Leticia Serpa Sampaio, Cecilia Rocha da Silva, Joao Batista de Andrade Neto, Helio Vitoriano Nobre JUnior, Romulo Rocha Regis
Summary: The experimental solution containing Lippia sidoides essential oil showed antimicrobial activity against different pathogens, reduced the metabolic activity of C. albicans biofilm significantly, and caused cell wall damage at low concentrations, making it a potential alternative for the prevention and treatment of denture-induced infections.
Article
Biochemistry & Molecular Biology
Lana Glerieide Silva Garcia, Maria Gleiciane da Rocha, Laysa Rocha Lima, Arcelina Pacheco Cunha, Jonathas Sales de Oliveira, Ana Raquel Colares de Andrade, Nagila Maria Pontes Silva Ricardo, Waldemiro Aquino Pereira-Neto, Jose Julio Costa Sidrim, Marcos Fabio Gadelha Rocha, Rodrigo Silveira Vieira, Raimunda Samia Nogueira Brilhante
Summary: The study aimed to produce and characterize chitosan microparticles loaded with essential oils, evaluate their anti-Candida activity, and assess essential oil release profile. The results showed that these microparticles have promising antibiofilm activity against Candida.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Tomonori Takano, Hayami Kudo, Shuhei Eguchi, Asami Matsumoto, Kentaro Oka, Yukitaka Yamasaki, Motomichi Takahashi, Takuro Koshikawa, Hiromu Takemura, Yuka Yamagishi, Hiroshige Mikamo, Hiroyuki Kunishima
Summary: The concentrations of lactobacillus metabolites have varied effects on the suppression of Candida albicans biofilms. Lactate and hydrogen peroxide produced by lactobacillus are both required to inhibit C. albicans growth. Lactobacillus strains that significantly inhibit biofilm formation also inhibit C. albicans adhesion to epithelial cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Najla A. Alshaikh, Kahkashan Perveen
Summary: This study provides experimental evidence that thyme essential oil (TEO) has antifungal activity against fluconazole-resistant clinical isolates of C. albicans. TEO successfully inhibits the growth, germ tube formation, and budding of fungal pathogens at low doses, showing potential as an alternative to fluconazole for drug-resistant strains.
Article
Polymer Science
Nichakorn Songsang, Chuchai Anunmana, Matsayapan Pudla, Trinuch Eiampongpaiboon
Summary: Incorporating Litsea cubeba essential oil into soft lining materials inhibited the growth of Candida albicans and Streptococcus mutans without affecting cytotoxicity and surface hardness. The higher the concentration of LCEO, the greater the inhibitory effect on oral pathogens without compromising the integrity of the materials.
Article
Infectious Diseases
Shuai Wang, Peng Wang, Jun Liu, Chunxia Yang, Qiangyi Wang, Mingze Su, Ming Wei, Li Gu
Summary: This study compared the effects of different essential fatty acids (EFAs) on the biofilm formation and eradication of C. albicans. The results suggest that EPA and AA may serve as potential new antifungal agents for the treatment of clinical infections caused by C. albicans biofilms.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Zinnat Shahina, Ali Molaeitabari, Taranum Sultana, Tanya Elizabeth Susan Dahms
Summary: Plant-based essential oils, specifically cinnamon leaf and clove oils, and their combination exhibit promising anti-virulence effects against Candida albicans by inhibiting hyphal and mycelial growth, which are essential factors in the pathogen's virulence.
Article
Microbiology
Tea Ganic, Stefana Vuletic, Biljana Nikolic, Magdalena Stevanovic, Maja Kuzmanovic, Dusan Kekic, Sasa Durovic, Stefana Cvetkovic, Dragana Mitic-Culafic
Summary: This study compared the effects of cinnamon essential oil and its emulsion on biofilm forming Acinetobacter baumannii clinical isolates, and investigated the toxicological aspects of their possible applications. The results showed that both cinnamon essential oil and its emulsion exhibited significant antibacterial/antibiofilm effects, with the emulsion showing even stronger efficacy.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Abdullah A. Al-Ghanayem
Summary: Lemongrass oil exhibits antifungal and anti-biofilm activity against Candida albicans, with no cytotoxic effect on HaCaT keratinocytes at lower concentrations.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ting Zhao, Kang Zhang, Gaoxiang Shi, Kelong Ma, Benfan Wang, Jing Shao, Tianming Wang, Changzhong Wang
Summary: Vulvovaginal candidiasis (VVC) is a common inflammatory disease of the vagina caused by Candida albicans. Antifungal drugs used to treat VVC are limited in their effectiveness due to drug-resistant strains. This study found that the herbal alkaloid berberine can inhibit the adhesion of C. albicans to vaginal epithelial cells by modulating the expression of certain proteins and balancing inflammatory responses. These findings suggest that berberine may be a potential therapeutic agent for VVC and highlight the potential of natural herbs in antifungal therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Paula V. V. Cordero, Maria G. Alvarez, Edwin J. J. Gonzalez Lopez, Daniel A. A. Heredia, Edgardo N. N. Durantini
Summary: Invasive candidiasis is increasing in complexity and has become a major cause of morbidity and mortality. The use of photodynamic inactivation, specifically with chlorin-based sensitizers, shows promise in eliminating Candida albicans. These sensitizers were able to effectively eradicate C. albicans in different forms, including planktonic cells, pseudohyphae, and biofilms. The studies demonstrated the effectiveness of these chlorin-based sensitizers as photosensitizing agents against C. albicans.
Article
Immunology
Komathy Munusamy, Mun Fai Loke, Jamuna Vadivelu, Sun Tee Tay
Summary: Candidiasis is a common fungal infection with high morbidity and mortality in immunocompromised patients. This study compared the proteomes of planktonic cells and biofilms of Candida albicans using LC-MS, revealing different biological and metabolic processes for each lifestyle. Proteomic data is available via ProteomeXchange with identifiers for biofilm and planktonic cell proteomes.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Emerenziana Ottaviano, Giovanna Baron, Laura Fumagalli, Jessica Leite, Elisa Adele Colombo, Angelica Artasensi, Giancarlo Aldini, Elisa Borghi
Summary: The study demonstrated the efficacy of urinary cranberry metabolites VAL and 4-HBA in inhibiting Candida adhesion and biofilm formation in vitro. These metabolites interfered with yeast adhesion by modulating key gene expression, leading to a significant reduction in biofilm biomass and metabolic activity. The findings suggest that VAL and 4-HBA could be potential targets for drug development in preventing genitourinary Candida infections.
Article
Food Science & Technology
Quan Lin, Yanxin Li, Maokun Sheng, Jiaman Xu, Xiaoyan Xu, Jintae Lee, Yulong Tan
Summary: In recent years, there has been an increasing trend in Candida contamination caused by Candida mastitis, which has a significant impact on the hygienic quality of raw milk and dairy products. The biofilm produced by Candida albicans plays a critical role in fungal infection by protecting the fungus from host defense and drug attacks. Therefore, finding effective means to reduce the biofilm and drug resistance of Candida albicans has become an urgent problem. This study investigated the anti-biofilm effect of berberine-loaded chitosan nanoparticles on Candida albicans and explored the antifungal mechanism of released berberine.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Microbiology
Philipp Reuter-Weissenberger, Juliane Meir, J. Christian Perez
Summary: This study identifies the previously uncharacterized transcription regulator ZCF8 in human-associated Candida albicans as crucial for maintaining vacuole homeostasis and modulating the attachment of the fungus to epithelial cells depending on vacuolar status. The findings suggest that fungal vacuole physiology regulation plays a significant role in shaping the physical interactions between Candida cells and mammalian mucosal surfaces.
Article
Microbiology
Genevieve LeBel, Katy Vaillancourt, Philippe Bercier, Daniel Grenier
ARCHIVES OF MICROBIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Amel Ben Lagha, Elisoa Andrian, Daniel Grenier
MOLECULAR ORAL MICROBIOLOGY
(2019)
Article
Microbiology
Mariem Souissi, Jabrane Azelmat, Kamel Chaieb, Daniel Grenier
Article
Chemistry, Medicinal
Amel Ben Lagha, Genevieve LeBel, Daniel Grenier
PHYTOTHERAPY RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Daniel Grenier, Eve Marcoux, Jabrane Azelmat, Amel Ben Lagha, Philippe Gauthier
Article
Multidisciplinary Sciences
Amel Ben Lagha, Jabrane Azelmat, Katy Vaillancourt, Daniel Grenier
Summary: This study characterized the anti-inflammatory properties of a polyphenolic cinnamon fraction, showing that it reduced IL-6, IL-8, and TNF-alpha secretion in a dose-dependent manner and may prevent NF-kappa B activation induced by LPS. The cinnamon fraction also reduced LPS binding to monocytes and may act as a natural PPAR-gamma ligand, suggesting therapeutic potential for the treatment of periodontal diseases.
Article
Multidisciplinary Sciences
Amel Ben Lagha, Genevieve Pellerin, Katy Vaillancourt, Daniel Grenier
Summary: Periodontal diseases, including gingivitis and periodontitis, are a global oral health problem caused by bacteria like Porphyromonas gingivalis. This study found that a phenolic extract from tart cherry juice can inhibit the growth and activities of P. gingivalis, and protect the integrity of the oral epithelial barrier.
Article
Dentistry, Oral Surgery & Medicine
Pierre-Olivier Miron, Amel Ben Lagha, Jabrane Azelmat, Anibal Diogenes, Juliana Nascimento Santos, Daniel Grenier
Summary: The study found that TNF- has detrimental effects on the viability, proliferation rate, and mineralization potential of stem cells of the apical papilla. Additionally, treating SCAP with TNF- reduced the secretion of periostin and increased the secretion of various cytokines and MMPs.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Katy Vaillancourt, Amel Ben Lagha, Daniel Grenier
Summary: Green tea extract and EGCG can reduce the cytotoxicity of the chemotherapeutic agent irinotecan towards oral epithelial cells, decrease intracellular ROS production, inhibit cell proliferation and migration, and suppress the secretion of cytokines and MMPs.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Amel Ben Lagha, Ying Yang, Harsh M. Trivedi, James G. Masters, Daniel Grenier
Summary: The study demonstrated that Dual Zinc plus Arginine formulations can protect the barrier integrity of gingival keratinocytes, promote cell proliferation, and enhance cell migration.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Amel Ben Lagha, Patricia Maquera Huacho, Daniel Grenier
Summary: The study demonstrated that a cocoa extract rich in epicatechin can effectively inhibit the growth, biofilm formation, adherence, and H2S production of F. nucleatum. Additionally, it showed anti-inflammatory properties, reduced IL-6 and IL-8 production, and enhanced epithelial barrier function, suggesting that it may have potential in preventing and treating periodontal diseases.
Article
Biotechnology & Applied Microbiology
Katy Vaillancourt, Genevieve LeBel, Nahuel Fittipaldi, Michel Frenette, Marcelo Gottschalk, Daniel Grenier
Summary: In this study, a new bacteriocin produced by Streptococcus pluranimalium 2N12 was characterized. This bacteriocin, called pluranimalicin 2N12, exhibited antibacterial activity against Streptococcus suis and showed a dual action of both antibacterial and anti-inflammatory effects.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Infectious Diseases
Jinpeng Li, Qingying Fan, Jing Zuo, Bingqian Xue, Xiaoling Zhang, Ying Wei, Liyun Sun, Daniel Grenier, Li Yi, Xiaogai Hou, Yang Wang
Summary: This study suggests that the combination of paeoniflorin and norfloxacin can effectively combat FQ-resistant Streptococcus suis. Paeoniflorin inhibits the LuxS/AI-2 quorum sensing system and down-regulates the transcription of the FQ efflux pump gene, enhancing the bactericidal effect of norfloxacin. Additionally, paeoniflorin inhibits biofilm formation, promoting the ability of norfloxacin to kill S. suis. In a mouse model, paeoniflorin in combination with norfloxacin demonstrates efficacy in treating S. suis infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Genevieve Pellerin, Laurent Bazinet, Daniel Grenier
Summary: The study found that removal of organic acids from cranberry juice through electrodialysis weakened its antibacterial effect against certain periodontal pathogens, but had varying effects on the adherence of these pathogens to oral epithelial cells. Additionally, deacidification of cranberry juice reduced its cytotoxicity for oral epithelial cells and attenuated its anti-inflammatory effect.