期刊
BIOINTERPHASES
卷 11, 期 3, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1116/1.4960654
关键词
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资金
- Plasma Technology Laboratory
- Coordination for the Improvement of Higher Level Personnel (CAPES) from Brazil [11838-13-2]
- State of Sao Paulo Research Foundation (FAPESP) [2013/08451-1]
- National Science Foundation (NSF) [1067424]
- NIH [R03 AR064005]
Biofunctionalized surfaces for implants are currently receiving much attention in the health care sector. Our aims were ( 1) to create bioactive Ti-coatings doped with Ca, P, Si, and Ag produced by microarc oxidation ( MAO) to improve the surface properties of biomedical implants, ( 2) to investigate the TiO2 layer stability under wear and corrosion, and ( 3) to evaluate human mesenchymal stem cells ( hMSCs) responses cultured on the modified surfaces. Tribocorrosion and cell experiments were performed following the MAO treatment. Samples were divided as a function of different Ca/P concentrations and treatment duration. Higher Ca concentration produced larger porous and harder coatings compared to the untreated group ( p<0.001), due to the presence of rutile structure. Free potentials experiments showed lower drops ( 0.6 V) and higher coating lifetime during sliding for higher Ca concentration, whereas lower concentrations presented similar drops ( 0.8 V) compared to an untreated group wherein the drop occurred immediately after the sliding started. MAO-treated surfaces improved the matrix formation and osteogenic gene expression levels of hMSCs. Higher Ca/P ratios and the addition of Ag nanoparticles into the oxide layer presented better surface properties, tribocorrosive behavior, and cell responses. MAO is a promising technique to enhance the biological, chemical, and mechanical properties of dental implant surfaces. (C) 2016 American Vacuum Society.
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