Article
Biochemistry & Molecular Biology
Jeeyong Lee, Da Yeon Kim, Younjoo Kim, Ui Sup Shin, Kwang Seok Kim, Eun Ju Kim
Summary: To discover genes associated with radioresistance in colorectal cancer (CRC), an RNA sequencing dataset was analyzed. Among the candidates, IGFL2-AS1, a long non-coding RNA, showed a correlation with radioresistance. Further investigation revealed that as radioresistance increased, the expression of IGFL2-AS1 also increased in CRC cell lines and samples. Knockdown of IGFL2-AS1 decreased radioresistance and cell migration, indicating its functional role in radioresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Esra Bozgeyik
Summary: Testing for genomic variations, from traditional methods like restriction fragment length polymorphism analysis to next generation sequencing analysis, provides a powerful and reliable approach for cancer testing. Non-coding RNAs have a significant impact on the development and progression of human cancers, including prostate cancer. However, the low stability of these molecules under laboratory conditions poses challenges for their clinical utility. The identification and interpretation of single nucleotide polymorphisms associated with prostate cancer susceptibility in genomic regions encoding non-coding RNAs offer a promising avenue for cancer testing.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2023)
Article
Plant Sciences
Sophie Watts, Michel McElroy, Zoe Migicovsky, Hugo Maassen, Robin van Velzen, Sean Myles
Summary: The study found that Cannabis labelling is associated with genetic variations in terpene synthase genes.
Article
Multidisciplinary Sciences
Svetlana Kalmykova, Marina Kalinina, Stepan Denisov, Alexey Mironov, Dmitry Skvortsov, Roderic Guigo, Dmitri Pervouchine
Summary: The ability of nucleic acids to form double-stranded structures is essential for all living systems, with long-range RNA structures containing conserved complementary regions abundant in human protein-coding genes. PCCRs, mainly located within introns, have a distinct splicing pattern and may affect splicing widely.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Zhao Li, Lin Liu, Changrui Feng, Yuxin Qin, Jingfa Xiao, Zhang Zhang, Lina Ma
Summary: LncBook 2.0 is a comprehensive resource for human lncRNAs that has been updated and enhanced to include new transcripts, genes, conservation features, small protein encoding, expression and DNA methylation profiles, and interactions with proteins and miRNAs. It provides a high-quality collection of lncRNA genes and transcripts with abundant annotations, allowing users to decipher the functional significance of lncRNAs in different biological contexts.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Endocrinology & Metabolism
Mengling You, Rong Rong, Zhou Zeng, Cong Fan, Haibo Li, Qian Yang, Dan Ji
Summary: In recent years, the importance of long non-coding RNAs (lncRNAs) in various diseases, including glaucoma, has been widely reported. However, the specific mechanisms of lncRNAs in the pathogenesis and progression of glaucoma are still unclear. This research aims to identify differentially expressed lncRNAs and mRNAs in glaucoma and provide a basis for further exploration of the specific mechanism of action of lncRNAs in glaucoma progression.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Shengchao Xu, Lu Tang, Zhixiong Liu, Kui Yang, Quan Cheng
Summary: This study developed and validated a novel ARL signature for the classification of diffuse glioma, which was closely associated with glioma immune microenvironment and could serve as a promising prognostic biomarker for glioma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mustafa S. Pir, Halil Bilgin, Ahmet Sayici, Furkan M. Torun, Pei Zhao, Yahong Kang, Sebiha Cevik, Oktay Kaplan
Summary: ConVarT is an integrated search engine that helps match variants between humans, mice, and Caenorhabditis elegans. Analyzing phenotypic variants from mice and C. elegans can provide clues about the functional consequences of human genetic variants.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Xin-Hui Cao, Kai Yang, Ming-Xing Liang, Pei Ma, Di Xu, Yin-Jiao Fei, Wei Zhang, Xiu Chen, Jin-Hai Tang
Summary: This study investigated the expression profiles of lncRNAs in breast cancer cells affected by adipocytes, revealing their involvement in material metabolism and potential impact on cancer progression. The findings suggest that lncRNAs could be useful in predicting therapeutic responses and prognosis for obese breast cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Soudeh Ghafouri-Fard, Sajad Najafi, Bashdar Mahmud Hussen, Aryan R. Ganjo, Mohammad Taheri, Mohammad Samadian
Summary: Long non-coding RNAs (lncRNAs) are a heterogeneous group of ncRNAs with a characteristic size of more than 200 nucleotides. DLX6-AS1 is an lncRNA that has been found to be up-regulated in various cancers, and it promotes the oncogenic phenotype of cancer cells by affecting signaling pathways. It is associated with clinicopathological features and shorter survival in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Qinglin Feng, Cheng Qian, Shibing Fan
Summary: The study established an effective HRL model for prognosis assessment of LGG patients by identifying hypoxia-related lncRNAs and constructing a predictive model with 8 informative lncRNAs. The model showed good performance in predicting overall survival and correlated with important clinicopathologic characteristics, suggesting potential for personalized treatment design in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Salman F. Banani, Lena K. Afeyan, Susana W. Hawken, Jonathan E. Henninger, Alessandra Dall'Agnese, Victoria E. Clark, Jesse M. Platt, Ozgur Oksuz, Nancy M. Hannett, Ido Sagi, Tong Ihn Lee, Richard A. Young
Summary: This study comprehensively maps pathogenic mutations related to condensates and finds that these mutations may lead to condensate dysregulation, affecting a wide range of human diseases. These findings provide a foundation for researching disease mechanisms and treatments.
DEVELOPMENTAL CELL
(2022)
Review
Pharmacology & Pharmacy
Bei Wang, Wen Xu, Yuxuan Cai, Chong Guo, Gang Zhou, Chengfu Yuan
Summary: CASC15, a long non-coding RNA, is closely related to tumor development and its expression varies in different types of tumors, potentially affecting tumor growth and apoptosis.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Wenwen Zhong, Dejuan Wang, Bing Yao, Xiaoxia Chen, Zhongyang Wang, Hu Qu, Bo Ma, Lei Ye, Jianguang Qiu
Summary: This study identified prognosis-related lncRNAs in bladder cancer by analyzing the expression profiles of lncRNAs and CNVs, and revealed a risk-score signature associated with overall survival in BLCA through multi-omics integration analysis. The enrichment analysis indicated that the imbalance in MAPK signaling pathway, focal adhesion pathway, and JAK-STAT signaling pathway is closely related to tumor development in BLCA.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Cell Biology
Xiaohua Jiang, Daren Zhao, Asim Ali, Bo Xu, Wei Liu, Jie Wen, Huan Zhang, Qinghua Shi, Yuanwei Zhang
Summary: MeiosisOnline is a comprehensive database containing known functional genes and potential candidates, providing a wealth of information and classification related to meiosis. 165 mouse genes were predicted as potential candidates for meiosis. The database's search tools and user-friendly interface greatly assist researchers in studying meiosis efficiently and easily.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ya Cui, Fanglue Peng, Dan Wang, Yumei Li, Jason Sheng Li, Lei Li, Wei Li
Summary: Genome-wide association studies have identified numerous non-coding SNPs associated with human traits and diseases, with functional interpretation remaining a challenge. The concept of 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs) has been established to interpret a portion of GWAS SNPs. The 3'aQTL-atlas provides a comprehensive database of nearly 1.49 million SNPs associated with APA across 49 human tissues, aiming to explain genetic basis of APA and APA-linked susceptibility genes in human traits and diseases.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yongbiao Xue, Yiming Bao, Zhang Zhang, Wenming Zhao, Jingfa Xiao, Shun-min He, Guoqing Zhang, Yixue Li, Zhao Guoping, Runsheng Chen, Jingyao Zeng, Yadong Zhang, Yun-fei Shang, Jialin Mai, Shuo Shi, Mingming Lu, Congfan Bu, Zhewen Zhang, Zhenglin Du, Yinying Wang, Hongen Kang, Tianyi Xu, Lili Hao, Peilin Jia, Shuai Jiang, Qiheng Qian, Tong-tong Zhu, Yunfei Shang, Wenting Zong, Tong Jin, Yuansheng Zhang, Dong Zou, Zhang Zhang, Qiang Du, Changrui Feng, Lina Ma, Sisi Zhang, Anke Wang, Lili Dong, Yan-qing Wang, Wan Liu, Xing Yan, Yunchao Ling, Guoping Zhao, Zhihua Zhou, Wang Kang, Tao Zhang, Shuai Ma, Haoteng Yan, Zunpeng Liu, Zejun Ji, Yusheng Cai, Si Wang, Moshi Song, Jie Ren, Qi Zhou, Jing Qu, Weiqi Zhang, Guanghui Liu, Xu Chen, Tingting Chen, Zhang Sisi, Yanling Sun, Caixia Yu, Bixia Tang, Junwei Zhu, Shuang Zhai, Yubin Sun, Qiancheng Chen, Xiaoyu Yang, Xin Zhang, Zhengqi Sang, Yonggang Wang, Yilin Zhao, Huanxin Chen, Li Lan, Yanqing Wang, Yingke Ma, Yaokai Jia, Xin-chang Zheng, Meili Chen, Zou Dong, Tongtong Zhu, Chen Ming, Guangyi Niu, Rong Pan, Wei Jing, Jian Sang, Chang Liu, Yujia Xiong, Hao Lili, Mochen Zhang, Guoliang Wang, Lizhi Yi, Zhao Wei, Wenting Zong, Song Wu, Zhuang Xiong, Li Rujiao, Gong Zheng, Rujiao Li, Lin Liu, Zhao Li, Qianpeng Li, Jing Wei, Sicheng Luo, Jiajia Wang, Yirong Shi, Honghong Zhou, Peng Zhang, Tingrui Song, Yanyan Li, Fei Yang, Mengwei Li, Zhao-hua Li, Hongen Kang, Xinchang Zheng, Ru-jiao Li, Dongmei Tian, Xiaonan Liu, Cuiping Li, Xufei Teng, Shuhui Song, Yang Zhang, Guangyi Niu, Tongtong Zhu, Yuansheng Zhang, Ruru Chen, Rongqin Zhang, Feng Xu, Yifan Wang, Yunchao Ling, Chenfen Zhou, Haizhou Wang, Andrew E. Teschendorff, Yungang He, Yang Zhen, Cuiping Li, Junwei Zhu, Lun Li, Na Li, Zheng Gong, Meili Chen, Ying Cui, Guangya Duan, Jin Tong, Gangao Wu, Tianhao Huang, Enhui Jin, Wei Zhao, Hailong Kang, Zhonghuang Wang, Jingyao Zeng, Hua Chen, Mingkun Li, Wenming Zhao, Wanshan Ning, Yu Xue, Yanhu Liu, Ying Cui, Qijun Zhou, Xingyan Liu, Longlong Zhang, Bingyu Mao, Shihua Zhang, Yaping Zhang, Guodong Wang, Qianghui Zhu, Xin Li, Menghua Li, Yuanming Liu, Hong Luo, Xiaoyuan Wu, Haichun Jing, Yitong Pan, Ming Chen, Lina Ma, Leisheng Shi, Mingkun Li, Li Lan, Yiming Bao, Wen-ming Zhao, Zhixiang Zuo, Jian Ren, Xinxin Zhang, Yun Xiao, Xia Li, Dan Liu, Chi Zhang, Yu Xue, Zheng Zhao, Tao Jiang, Wanying Wu, Fangqing Zhao, Xianwen Meng, Di Peng, Hao Luo, Feng Gao, Shaofeng Lin, Chuijie Liu, Anyuan Guo, Hao Yuan, Tianhan Su, Yong E. Zhang, Yincong Zhou, Weizhi Zhang, Shanshan Fu, Xiaodan Tan, Yubin Xie, Guoji Guo, Chenwei Wang, Xingyu Liao, Xin Gao, Jianxin Wang, Guiyan Xie, Chunhui Yuan, Feng Tian, Dechang Yang, Dachao Tang, Wenyi Wu, Yujie Gou, Cheng Han, Qinghua Cui, Xiang Shang Li, Chuan-Yun Li, XiaoTong Luo, Jia Ren, Xia Li
Summary: The National Genomics Data Center (NGDC) of China National Center for Bioinformation (CNCB) provides database resources to support global research, with a focus on single-cell omics and precision medicine. They continuously scale up and update core database resources, daily update SARS-CoV-2 genome data, and establish OpenLB and update Database Commons.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiajia Wang, Yirong Shi, Honghong Zhou, Peng Zhang, Tingrui Song, Zhiye Ying, Haopeng Yu, Yanyan Li, Yi Zhao, Xiaoxi Zeng, Shunmin He, Runsheng Chen
Summary: Piwi-interacting RNAs are small noncoding RNAs with diverse functions, and piRBase is a curated resource aimed at assisting functional analysis of piRNAs. The latest release, piRBase v3.0, includes over 181 million unique piRNA sequences from 44 species, along with disease-related piRNAs and regulatory relationship visualizations. The web interface has been redesigned for a better user experience, and new content such as gold standard piRNA sets and expression data has been added.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yiwei Niu, Xueyi Teng, Honghong Zhou, Yirong Shi, Yanyan Li, Yiheng Tang, Peng Zhang, Huaxia Luo, Quan Kang, Tao Xu, Shunmin He
Summary: This study presents a comprehensive map of non-reference MEIs constructed from 5675 genomes, including Chinese samples and samples from the 1000 Genomes Project. LINE-1 insertions were found to be highly enriched in centromere regions, and MEIs were estimated to account for approximately 9.3% of all protein-truncating events per genome. A companion database named HMEID was also established for public use.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Xiaoli Cui, Ruijin Zhang, Ye Yang, Erzhong Wu, Yiheng Tang, Zhihua Zhao, Chao Li, Lei Yang, Xueyi Teng, Yanzhen Ye, Ya Cui, Feng Xu, Zewen Su, Dongpeng Wang, Dongdong Zhang, Yan Yang, Jianyuan Sun, Jianjun Luo, Shuli Zhang, Runsheng Chen, Jianzhong Jeff Xi
Summary: Carip, a previously uncharacterized long non-coding RNA, regulates the phosphorylation of AMPA and NMDA receptor subunits through its interaction with CaMKIIb, thereby modulating long-term synaptic plasticity and spatial learning and memory in mice.
Article
Microbiology
Li Wan, Hexin Li, Gaoyuan Sun, Lili Zhang, Hongtao Xu, Fei Su, Shunmin He, Fei Xiao
Summary: In this study, a powerful framework was developed to investigate the mutagenesis effect and proliferation influence of chemotherapeutic agents on gut microbiota, as well as the interaction between these drugs and gut microbiota. The results showed that the drugs significantly affected mutation signatures of gut microbiota and led to changes in bacteriome and functional alterations.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Baochan Yang, Yiming Zhang, Lixin Sun, Jian Wang, Zunling Zhao, Zhuoyue Huang, Wei Mao, Rong Xue, Runsheng Chen, Jianjun Luo, Tianyu Wang, Jianzhuang Jiang, Yan Qin
Summary: Ferroptosis is a recently discovered programmed cell death induced by cellular ferrous ion bursts and subsequent Fenton reactions. In this study, hierarchically assembled gamma-Fe2O3 nanocrystal-based nanoparticles were developed, which showed switchable magnetic resonance imaging, enhanced ferroptosis efficiency, and high photothermal conversion. These nanoparticles enabled clear visualization of tissues and highly efficient photothermal therapy, achieving synergistic cancer therapy for tumor ablation. The RNA sequencing analysis revealed the multifaceted role of this therapy in cancer cell signaling, with upregulated cellular respiration and electron transport and downregulated epigenetic pathways, leading to cellular apoptosis. Gamma-Fe2O3 architectures provide a new possibility for highly efficient deep tumor treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yu Zheng, Huaxia Luo, Xueyi Teng, Xinpei Hao, Xiaoyu Yan, Yiheng Tang, Wanyu Zhang, Yuanxin Wang, Peng Zhang, Yanyan Li, Yi Zhao, Runsheng Chen, Shunmin He
Summary: The updated NPInter database provides valuable and informative ncRNA interaction information for biological researchers, including RNA-DNA interactions, RNA interactions between SARS-CoV-2 virus and its host, and the expression specificity of long noncoding RNAs in different cell types.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yongbiao Xue, Yiming Bao, Zhang Zhang, Wenming Zhao, Jingfa Xiao, Shun-min He, Guoqing Zhang, Yixue Li, Guoping Zhao, Runsheng Chen, Yingke Ma, Meili Chen, Cuiping Li, Shuai Jiang, Dong Zou, Zheng Gong, Xue-tong Zhao, Yanqing Wang, Junwei Zhu, Shuhui Song, Yunchao Ling, Yiwei Wang, Jiaxin Yang, Xinhao Zhuang, Guangya Duan, Gangao Wu, Xiaoning Chen, Dongmei Tian, Zhaohua Li, Yan-ling Sun, Zhenglin Du, Lili Hao, Yuan Gao, Bixia Tang, Yadong Zhang, Hao Zhang, Zaichao Zhang, Qiheng Qian, Zhewen Zhang, Hailong Kang, Tianhao Huang, Zhiqiang Xia, Xincheng Zhou, Jin-quan Chao, Zhonghuang Wang, Jun-wei Zhu, Sisi Zhang, Weimin Tian, Wenquan Wang, Song Wu, Yue Huang, Mochen Zhang, Guoliang Wang, Xin-chang Zheng, Wenting Zong, Wei Zhao, Peiqi Xing, Rujiao Li, Zhaoqi Liu, Mingming Lu, Fengchun Yang, Jialin Mai, Qianwen Gao, Xiaowei Xu, Hongyu Kang, Li Hou, Yunfei Shang, Qiheng Qain, Jie Liu, Meiye Jiang, Congfan Bu, Jinyue Wang, Jingyao Zeng, Jiao Li, Siyu Pan, Hongen Kang, Xinxuan Liu, Shiqi Lin, Na Yuan, Peilin Jia, Xinchang Zheng, Yanling Sun, Zhuang Xiong, Fei Yang, Xu Chen, Tingting Chen, Caixia Yu, Lili Dong, Shuang Zhai, Yubin Sun, Qiancheng Chen, Xiaoyu Yang, Xin Zhang, Zhengqi Sang, Yonggang Wang, Yilin Zhao, Huanxin Chen, Li Lan, Yan-qing Wang, Anke Wang, Yaokai Jia, Xuetong Zhao, Yitong Pan, Xiaonan Liu, Rongqin Zhang, Yi Wang, Lina Ma, Xufei Teng, Lun Li, Na Li, Ying Cui, Tong Jin, Enhui Jin, Tao Zhang, Tianyi Xu, Ming Chen, Guangyi Niu, Rong Pan, Tongtong Zhu, Yuan Chu, Jian Sang, Yuanpu Zhang, Zhennan Wang, Yuan-sheng Zhang, Qiliang Yao, Xinran Zhang, Xutong Guo, Zhao Li, Lin Liu, Changrui Feng, Yuxin Qin, Wei Jing, Sicheng Luo, Tong-tong Zhu, Yuansheng Zhang, Zis-han Wu, Qianpeng Li, Pei Liu, Yongqing Sun, Zhuojing Fan, Wen-ming Zhao, Wen-Kang Shen, An-Yuan Guo, Zhixiang Zuo, Jian Ren, Xinxin Zhang, Yun Xiao, Xia Li, Dan Liu, Chi Zhang, Yu Xue, Zheng Zhao, Tao Jiang, Wanying Wu, Fangqing Zhao, Xianwen Meng, Yujie Gou, Miaomiao Chen, Di Peng, Hao Luo, Feng Gao, Wanshan Ning, Wan Liu, Ruifang Cao, Guo-qing Zhang, Yuxiang Wei, Chun-Jie Liu, Gui-Yan Xie, Hao Yuan, Tianhan Su, Yong E. Zhang, Chenfen Zhou, Pengyu Wang, Yincong Zhou, Guoji Guo, Qiong Zhang, Shanshan Fu, Xiaodan Tan, Dachao Tang, Weizhi Zhang, Mei Luo, Yubin Xie, Ya-Ru Miao, Xinhe Huang, Zihao Feng, Xingyu Liao, Xin Gao, Jianxin Wang, Guiyan Xie, Chunhui Yuan, Dechang Yang, Feng Tian, Ge Gao, Wenyi Wu, Cheng Han, Qinghua Cui, Chunfu Xiao, Chuan-Yun Li, XiaoTong Luo, Qing Tang
Summary: The National Genomics Data Center (NGDC) of the China National Center for Bioinformation (CNCB) provides database resources to support global academic and industrial communities. The NGDC constantly expands and updates core database resources by archiving big data, conducting integrative analysis, and providing value-added curation. New database resources have been developed for infectious diseases and microbiology, cancer-trait association, and tropical plants. Additionally, resources for the monkeypox virus and SARS-CoV-2 have been newly constructed and regularly updated. All resources and services are publicly accessible at https://ngdc.cncb.ac.cn.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ya Cui, Frederick J. Arnold, Fanglue Peng, Dan Wang, Jason Sheng Li, Sebastian Michels, Eric J. Wagner, Albert R. La Spada, Wei Li
Summary: In this study, a 3' untranslated region (3' UTR) APA transcriptome-wide association study (TWAS) was performed to identify susceptibility genes for 11 brain disorders. The study revealed the importance of alternative polyadenylation (APA) in brain development and identified 354 significant genes associated with APA, including known risk genes for Parkinson's disease. The findings indicate that APA may regulate the translation, localization, and protein-protein interaction of target genes independently of mRNA expression or splicing.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yirong Shi, Yiwei Niu, Peng Zhang, Huaxia Luo, Shuai Liu, Sijia Zhang, Jiajia Wang, Yanyan Li, Xinyue Liu, Tingrui Song, Tao Xu, Shunmin He
Summary: This study presents a comprehensive map of 366,013 polymorphic short tandem repeats (pSTRs) in the human genome, based on deeply sequenced genomes. The study explores the associations between STR mutations and various genomic features, such as gene expression and alternative polyadenylation. It also investigates population differentiation and genotypes disease-causing STRs.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Li Wan, Peilei Hu, Lili Zhang, Zhao-Xi Wang, Joy Fleming, Bo Ni, Jianjun Luo, Cha-Xiang Guan, Liqiong Bai, Yunhong Tan, Haican Liu, Na Li, Tongyang Xiao, Hua Bai, Yong-An Zhang, Xian-En Zhang, Kanglin Wan, Lijun Bi, Songying Ouyang, Hongtai Zhang
Summary: A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Huaxia Luo, Peng Zhang, Wanyu Zhang, Yu Zheng, Di Hao, Yirong Shi, Yiwei Niu, Tingrui Song, Yanyan Li, Shilei Zhao, Hua Chen, Tao Xu, Shunmin He
Summary: Characterizing natural selection signatures and their relationship with phenotype spectra is crucial for understanding human evolution and biological mechanisms. By analyzing the genetic data of Han Chinese, we identified 24 genetic loci under recent selection, including immune-related and alcohol metabolism-related genes. The study revealed the impact of these selection signatures on the immune system, alcohol metabolism, and perception. Moreover, the study discovered polygenic adaptation in various complex traits and developed a database to display selection signals in multiple populations.
Review
Biochemistry & Molecular Biology
Yajing Hao, Ting Cai, Chang Liu, Xuan Zhang, Xiang-Dong Fu
Summary: In eukaryotic cells, the coupled reaction for cleavage and polyadenylation (CPA) at the 3' end of transcripts is a key step in generating mature mRNA. Alternative polyadenylation (APA) can produce mRNA isoforms with different 3' ends, which may affect the coding sequence or 3' UTR length. Recent studies have shown that APA can occur after transcription through a mechanism called sequential APA. This mini-review focuses on these new mechanisms of post-transcriptional APA.
MOLECULES AND CELLS
(2023)
