Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Alessandro Miola, Giulia Cattarinussi, Gilberto Antiga, Stefano Caiolo, Marco Solmi, Fabio Sambataro
Summary: Research indicates that specific emotional regulation abnormalities exist in BD patients, but their magnitude is smaller compared to BPD. Future therapeutic interventions should focus on targeting emotional regulation strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Andreas S. Lappas, Bartosz Helfer, Katarzyna Henke-Ciazynska, Myrto T. Samara, Nikos Christodoulou
Summary: This systematic review and meta-analysis assessed the efficacy, tolerability, and acceptability of Clonazepam in the treatment of acute mania. The results suggested that Clonazepam may be superior to a placebo in the acute phase of treatment and comparable to Lithium and Haloperidol in terms of efficacy, both acutely and in the medium to long term. Clonazepam may be an acceptable and well-tolerated treatment for acute mania, especially when used as an augmentation strategy. However, the limited sample sizes and underpowered comparisons restrict the generalizability of the findings and hinder firm clinical conclusions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychology, Clinical
Francesco Bartoli, Christian Nasti, Dario Palpella, Susanna Piacenti, Maria Elisa Di Lella, Stefano Mauro, Luca Prestifilippo, Cristina Crocamo, Giuseppe Carra
Summary: A systematic review and meta-analysis of 21 studies found that compared to bipolar disorder, unipolar mania is positively or negatively associated with factors such as male gender, age at onset, number of hospitalizations, family history, suicide attempts, comorbid anxiety disorders, and psychotic features. The evidence quality varied, but this study supports the idea that unipolar mania may represent a distinct diagnostic construct with specific clinical correlates. Further research is needed to better differentiate unipolar mania and improve personalized care approaches.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Behavioral Sciences
Susana Gomes-da-Costa, Wolfgang Marx, Filippo Corponi, Gerard Anmella, Andrea Murru, Maria Teresa Pons-Cabrera, Anna Gimenez-Palomo, Felipe Gutierrez-Arango, Cristian Daniel Llach, Giovanna Fico, Georgios D. Kotzalidis, Norma Verdolini, Marc Valenti, Michael Berk, Eduard Vieta, Isabella Pacchiarotti
Summary: This study found through a systematic review and meta-analysis that the use of lithium in patients with Bipolar Disorder does not significantly lead to weight gain. Shorter treatment duration is associated with more pronounced weight gain. There were no significant differences in weight gain between lithium and placebo, but weight gain with lithium was lower compared to other active comparators.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Goncalo Cotovio, Daniel Rodrigues da Silva, Estela Real Lage, Carolina Seybert, Albino J. Oliveira-Maia
Summary: Mood disorders are associated with lateralized brain dysfunction, with depression predominantly on the left side and mania predominantly on the right side. This study reviewed and summarized the asymmetry of motor cortical excitability measured by transcranial magnetic stimulation (TMS) in mood disorders. The study found interhemispheric asymmetry of motor cortical excitability, with lower left-hemisphere excitability in major depressive disorder and lower right hemisphere excitability in bipolar depression.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amanda Vega-Nunez, Carlos Gomez-Sanchez-Lafuente, Fermin Mayoral-Cleries, Antonio Bordallo, Fernando Rodriguez de Fonseca, Juan Suarez, Jose Guzman-Parra
Summary: Bipolar disorder (BD) is influenced by inflammatory and neurotrophic factors as well as clinical, social, and environmental factors. BDNF plays a significant role in the depressive component of BD. However, further controlled studies are needed to identify precise biomarkers for this disorder, as the results for other inflammatory mediators are inconsistent.
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
Adam Gedek, Zofia Szular, Anna Z. Antosik, Pawel Mierzejewski, Monika Dominiak
Summary: This study systematically summarized the effects of celecoxib on mood disorders and inflammatory parameters. The results showed that celecoxib had antidepressant efficacy in the treatment of major depression and mania, and it was also safe for up to 12 weeks. However, the effectiveness of celecoxib in bipolar depression is still uncertain, and more research is needed to explore the relationship between celecoxib treatment and inflammatory markers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Kyoung-Sae Na, Jae Myeong Kang, Seo-Eun Cho
Summary: The prevalence of DSM-5-defined mixed features in major depressive episodes (MDE) and manic/hypomanic episodes was found to be 11.6% and 26.8% respectively. The lowest prevalence of mixed features was observed in East Asian countries, ranging from 0-2.2%. Subgroup analysis did not identify any significant factors influencing the heterogeneity of prevalence rates.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliya
Summary: Cariprazine is a novel atypical antipsychotic drug that was approved by the USFDA in 2015 for the treatment of schizophrenia and bipolar manic or mixed episodes in adults. It differs pharmacologically from other antipsychotic drugs due to its partial agonist action on dopamine and serotonin receptors. It also has a unique pharmacokinetic profile due to the formation of two significant metabolites. This review study demonstrates the effectiveness and safety of cariprazine in bipolar I disorder and schizophrenia, highlighting its potential as a promising therapeutic alternative.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Psychology, Clinical
Sukanta Saha, Carmen C. W. Lim, Danielle L. Cannon, Lucinda Burton, Monique Bremner, Peter Cosgrove, Yan Huo, John J. McGrath
Summary: This study conducted a meta-analysis to explore the comorbidity between mood and anxiety disorders, finding consistent evidence of a substantial association regardless of diagnostic criteria, study timeframe, or adjustments. Clinicians should be aware of the high prevalence of this common comorbidity and ensure prompt identification and treatment.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Giulia Cossu, Antonio Preti, Davide Gyppaz, Oye Gureje, Mauro G. Carta
Summary: This review and meta-analysis explores the relationship between toxoplasma gondii infection and bipolar disorder (BD) by estimating the association strength between the two conditions using data from published studies. The findings support the relationship between toxoplasmosis infection and BD and suggest a need for further studies to explore the possible causal relationship.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Margherita Barbuti, Giulia Menculini, Norma Verdolini, Isabella Pacchiarotti, Georgios D. Kotzalidis, Alfonso Tortorella, Eduard Vieta, Giulio Perugi
Summary: The present systematic review aimed to summarize the evidence about treatment-emergent mood switches in patients with bipolar disorder (BD). Thirty-two original studies met the inclusion criteria, and the majority focused on manic switches with limited research on depressive switches. Treatment-emergent mania/hypomania ranged from 17.3% to 48.8% and was more frequent with antidepressant monotherapy compared to combination treatment with mood stabilizers. Depressive switches were detected in 5-16% of patients and were associated with antipsychotic use. Methodological heterogeneity and small sample sizes were limitations in the included studies.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Kamyar Keramatian, Jairo Pinto, Ayal Schaffer, Verinder Sharma, Serge Beaulieu, Sagar Parikh, Lakshmi N. Yatham
Summary: The median delay in diagnosis was found to be 5.0 years in BD-I and 11.0 years in BD-II. Clinical factors such as earlier age of onset, lifetime suicide attempts, and comorbid anxiety disorders were associated with longer delay in diagnosis, while the presence of lifetime psychotic symptoms and psychiatric hospitalizations were associated with a shorter delay. In conclusion, the study highlights the need for strategies for early identification and interventions in Bipolar Disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Tatiana Lauxen Peruzzolo, Jairo Vinicius Pinto, Thiago Henrique Roza, Augusto Ossamu Shintani, Ana Paula Anzolin, Vanessa Gnielka, Andre Moura Kohmann, Amanda Salvador Marin, Vitoria Ruschel Lorenzon, Andre Russowsky Brunoni, Flavio Kapczinski, Ives Cavalcante Passos
Summary: Post-traumatic stress disorder (PTSD) is associated with persistent inflammation, which may explain the increased prevalence of autoimmune conditions and accelerated aging in patients. In comparison to healthy controls, concentrations of C-reactive protein, interleukin 6, and tumor necrosis factor-alpha are significantly higher in individuals with PTSD.
MOLECULAR PSYCHIATRY
(2022)
Review
Psychiatry
Smadar V. Tourjman, Gabriella Buck, Didier Jutras-Aswad, Atul Khullar, Shane McInerney, Gayatri Saraf, Jairo V. Pinto, Stephane Potvin, Marie-Josee Poulin, Benicio N. Frey, Sidney H. Kennedy, Raymond W. Lam, Glenda MacQueen, Roumen Milev, Sagar V. Parikh, Arun Ravindran, Roger S. McIntyre, Ayal Schaffer, Valerie H. Taylor, Michael van Ameringen, Lakshmi N. Yatham, Serge Beaulieu
Summary: This task force report examines the association between cannabis use and bipolar disorder, major depressive disorder, and comorbid cannabis use disorder. The results indicate that cannabis use is associated with worsened course and functioning of both mood disorders, particularly in bipolar disorder. However, the treatment of comorbid cannabis use disorder and major depressive disorder did not show significant results.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Clinical Neurology
Miriam von Mucke Similon, Cecilia Paasche, Fas Krol, Bernard Lerer, Guy M. Goodwin, Michael Berk, Andreas Meyer-Lindenberg, Terence A. Ketter, Lakshmi N. Yatham, Joseph F. Goldberg, Gin S. Malhi, Rif El-Mallakh, Rasmus W. Licht, Allan H. Young, Flavio Kapczinski, Marnina Swartz, Michal Hagin, Carla Torrent, Alessandro Serretti, Aysegul Yildiz, Anabel Martinez-Aran, Sergio Strejilevich, Janusz Rybakowski, Gabriele Sani, Heinz Grunze, Gustavo Vazquez, Ana Gonzales Pinto, Jean Michel Azorin, Willem Nolen, Othman Sentissi, Carlos Lopez-Jaramillo, Benicio N. Frey, Andrew Nierenberg, Gordon Parker, David J. Bond, Adam Cohen, Alfonso Tortorella, Giulio Perugi, Eduard Vieta, Dina Popovic
Summary: This study provides consensus recommendations for the selection of clinical trial design in psychiatry by surveying clinical and academic experts. The expert panel achieved consensus on 7 out of 21 recommendations regarding the use of randomized clinical trials, strongly supporting their use.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Psychiatry
Joshua D. Rosenblat, M. Ishrat Husain, Yena Lee, Roger S. McIntyre, Rodrigo B. Mansur, David Castle, Hilary Offman, Sagar Parikh, Benicio N. Frey, Ayal Schaffer, Kyle T. Greenwaym, Nicolas Garel, Serge Beaulieu, Sidney H. Kennedy, Raymond W. Lam, Roumen Milev, Arun Ravindran, Valerie Tourjman, Michael Van Ameringen, Lakshmi N. Yatham, Valerie Taylor
Summary: There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Health Care Sciences & Services
Luc Saulnier, Kamyar Keramatian, Jordan Cohen
Summary: Concurrent substance use and mental health disorders in youth are addressed with a novel inpatient tertiary care facility. The facility, established in response to the opioid overdose crisis in British Columbia, serves as Canada's third concurrent disorders unit specifically for adolescents. Preliminary data from the program shows improved quality of life and reduced suicidality upon discharge, with differences observed between male and female patients. This evaluation highlights the effectiveness of this program and provides insights into an underanalyzed patient population.
JOURNAL FOR HEALTHCARE QUALITY
(2023)
Article
Psychiatry
Laura B. Jones, Melissa Vereschagin, Angel Y. Wang, Richard J. Munthali, Julia Pei, Chris G. Richardson, Priyanka Halli, Hui Xie, Brian Rush, Lakshmi Yatham, Anne M. Gadermann, Krishna Pendakur, Ana Paula Prescivalli, Lonna Munro, Ronny Bruffaerts, Randy P. Auerbach, Philippe Mortier, Daniel V. Vigo
Summary: This study aimed to examine time trends in suicidal ideation among post-secondary students in Canada over the first three waves of the COVID-19 pandemic and identify subpopulations at increased risk. While the general university student population showed relative resilience in terms of suicidal ideation, specific subpopulations, such as Chinese students or other non-Indigenous ethnic minorities, experienced higher risk factors related to suicidal ideation during the pandemic. Further monitoring and targeted support for at-risk subpopulations should be considered to address potential delayed impacts.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Ruiyang Ge, Roberto Sassi, Lakshmi N. N. Yatham, Sophia Frangou
Summary: This study classified mood and anxiety disorders in youth aged 9-10 years into three subtypes using multimodal neuroimaging data. These subtypes showed differences in brain development and functioning, and were closely associated with family conflict and social adversity.
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Kamyar Keramatian, Trisha Chakrabarty, Anais DuBois, Gayatri Saraf, Lakshmi N. Yatham
Summary: Depression is a common mood state in individuals with bipolar disorder and is the main cause of functional impairment and suicidality. Current treatments for bipolar depression are limited in effectiveness, but there are emerging options such as new atypical anti-psychotics and novel mechanisms of action like ketamine and mitochondrial modulators. However, more research is needed to validate and study these potential treatments.
Review
Substance Abuse
Faraz Honarvar, Saman Arfaie, Hanie Edalati, Arashk Ghasroddashti, Arad Solgi, Mohammad Sadegh Mashayekhi, Mohammad Mofatteh, Lily Yuxi Ren, Angela T. H. Kwan, Kamyar Keramatian
Summary: This study aimed to review the literature on neuroanatomical predictors of future problematic drinking in adolescents. A systematic review was conducted based on PRISMA guidelines. Studies that met the inclusion criteria suggested that neuroanatomical predictors of future problematic drinking in adolescents were distributed across various brain regions, such as the orbitofrontal cortex and paralimbic regions. However, the findings were largely heterogeneous.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Psychiatry
Jairo Vinicius Pinto, Jose Alexandre S. Crippa, Keila Maria Cereser, Mireia Fortes Vianna-Sulzbach, erico de Moura Silveira Jr, Gabriel Santana da Rosa, Manoella Guatimuzim Testa da Silva, Gabriel Henrique Hizo, Leonardo Simao Medeiros, Carlos Eduardo Santana de Oliveira, Giovana Bristot, Alline Cristina Campos, Francisco Silveira Guimaraes, Jaime E. C. Hallak, Antonio W. Zuardi, Lakshmi N. Yatham, Flavio Kapczinski, Marcia Kauer-Sant'Anna
Summary: The study aimed to test the efficacy of cannabidiol as an adjunctive treatment for bipolar depression. The results showed no significant difference between cannabidiol and placebo in the primary outcome, but exploratory analysis suggested some efficacy of cannabidiol in secondary outcomes. Further research with higher doses and better study designs is needed.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Meeting Abstract
Neurosciences
Roger McIntyre, Lakshmi Yatham, Eduard Vieta, Lauren Aronin, Binh Nguyen
NEUROPSYCHOPHARMACOLOGY
(2022)