Article
Multidisciplinary Sciences
Silviya Ruseva, Inna Popova, Valentin Lozanov, Vanio Mitev
Summary: The study examined levels of Met, Hcy, and polyamines in psoriasis patients, finding correlations between them. Significant increases in Met and polyamine concentrations were observed in psoriatic plaques. The results highlight the importance of a balanced protein diet and intake of vitamins B-12 and B-9 in psoriasis treatment.
Article
Immunology
Chaojian Chen, Shuo Liu, Junhao Liu, Ziqi Zheng, Yixi Zheng, Zhongliang Lin, Yuchun Liu
Summary: This study found no causal relationship between circulating Hcy levels and psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucia Coppo, Simona Scheggi, Graziella DeMontis, Raffaella Priora, Simona Frosali, Antonio Margaritis, Domenico Summa, Danila Di Giuseppe, Monica Ulivelli, Paolo Di Simplicio
Summary: This article discusses the relationship between increased plasma concentrations of total homocysteine (tHcy) and the onset/progression of diseases, but it is not yet clear how the increase in tHcy leads to pathological conditions. It is suggested that albumin may play a role in homocysteine toxicity, and further research on the redox role of albumin and thiol-disulfide exchange reactions could offer new therapeutic insights for reducing homocysteine toxicity.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Medicine, General & Internal
Christopher E. M. Griffiths, April W. Armstrong, Johann E. Gudjonsson, Jonathan N. W. N. Barker
Summary: Psoriasis is a common chronic skin disease with significant burden on individuals and society. It is associated with various medical conditions and can be managed through lifestyle modifications and personalized treatment approaches.
Review
Immunology
Yuxi Zhang, Xiaoqing Xu, Hui Cheng, Fusheng Zhou
Summary: Psoriasis is a chronic inflammatory skin disease with global prevalence, causing systemic complications and significant impact on patients' quality of life and overall health. The pathogenesis of psoriasis is influenced by environmental factors, genetics, epigenetics, and dysregulation of immune cells. The gene locus AIM2 is associated with psoriasis and is overexpressed in psoriatic keratinocytes. AIM2 plays a role in inflammation by releasing IL-1 beta and IL-18 through inflammasome activation, and it also affects immune regulation, cell death, and cell proliferation. AIM2 may influence the recurrence of psoriasis through trained immunity. This review provides a comprehensive understanding of AIM2 and its involvement in the development of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ranjitha Uppala, Lam C. Tsoi, Paul W. Harms, Bo Wang, Allison C. Billi, Emanual Maverakis, J. Michelle Kahlenberg, Nicole L. Ward, Johann E. Gudjonsson
Summary: Psoriasis is a chronic inflammatory skin condition with a wide range of clinical manifestations. Genetic studies have identified six genetic variants predisposing to pustular psoriasis, with IL-36 cytokines playing a central role in disease pathophysiology.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Clinical Neurology
Giulia Grande, Babak Hooshmand, Davide Liborio Vetrano, David A. Smith, Helga Refsum, Laura Fratiglioni, Petter Ljungman, Jing Wu, Andrea Bellavia, Kristina Eneroth, Tom Bellander, Debora Rizzuto
Summary: Air pollution is associated with an increased risk of dementia. Homocysteine and methionine play important roles in this association. High levels of homocysteine increase the risk of dementia linked to air pollution, while high levels of methionine reduce this risk.
Article
Medicine, General & Internal
Huilian Duan, Dezheng Zhou, Ning Xu, Tong Yang, Qi Wu, Zehao Wang, Yue Sun, Zhenshu Li, Wen Li, Fei Ma, Yongjie Chen, Yue Du, Meilin Zhang, Jing Yan, Changqing Sun, Guangshun Wang, Guowei Huang
Summary: This study examines the effects of APOE epsilon 4, MTHFR TT genotype, and unhealthy lifestyle on the risk of mild cognitive impairment (MCI). The results show that unhealthy lifestyle and high genetic risk are significantly associated with an increased risk of MCI among Chinese older adults, and the impact of unhealthy lifestyle is not influenced by genetic risk. The study suggests a synergistic interaction between lifestyle and genetic risk.
Article
Endocrinology & Metabolism
Wei-Ming Luo, Zhi-Peng Zhang, Wei Zhang, Jing-Yang Su, Xiao-Qian Gao, Xu Liu, Wan-Ying Wang, Chang-Tao Jiang, Zhong-Ze Fang
Summary: The study found a U-shaped curve relationship between homocysteine and diabetic retinopathy, with the homocysteine pathway having an impact on this relationship. A low concentration of homocysteine indicates a lack of other substances.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Lingyan Zhou
Summary: This study reviews the roles of homocysteine in the pathogenesis of Parkinson's disease and illustrates the harmful effects of hyperhomocysteinemia on Parkinson's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemical Research Methods
Nassr J. Obeid, Mahmoud Hussein Hadwan
Summary: This study presents an accurate and reliable protocol for quantifying the activity of homocysteine thiolactonase (HTase) using the CUPRAC method. The method was validated against a reference method, demonstrating its high reliability and accuracy.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Dermatology
Claire Q. Wang, Sokol Haxhinasto, Sandra Garcet, Norma Kunjravia, Inna Cueto, Juana Gonzalez, Darshna Rambhia, Olivier Harari, Matthew A. Sleeman, Jennifer D. Hamilton, Wei Keat Lim, Jan Freudenberg, George D. Kalliolias, Paresh Thakker, Robert Bissonnette, James G. Krueger
Summary: Palmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar psoriasis (NPPP) are localized, debilitating forms of psoriasis. This study found that NPPP shows more pronounced T helper 1-mediated inflammation, while PPPP exhibits stronger neutrophil-associated activity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Plant Sciences
Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek, Umesh Kumar Tanwar, Jolanta Floryszak-Wieczorek
Summary: Homocysteine plays a crucial role in the synthesis and metabolism of plants, influencing various biochemical reactions. It has toxic effects on plant cells when accumulated at high levels. However, the metabolic status of homocysteine in plants remains poorly studied.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Dermatology
J. J. Wu, A. Kavanaugh, M. G. Lebwohl, R. Gniadecki, J. F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that is often associated with comorbidities, particularly metabolic syndrome. The underlying pathophysiology of psoriasis and metabolic syndrome appears to involve genetic predispositions and inflammatory pathways. Biologic treatments for psoriasis may not only improve skin lesions but also reduce the risk of developing atherosclerosis and cardiovascular diseases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Clinical Neurology
Shuang Li, Guangjian Li, Xia Luo, Yan Huang, Lan Wen, Jinglun Li
Summary: Cerebral small vessel disease (cSVD) is a clinical syndrome that affects the brain's small vessels, with an association to high total serum homocysteine levels and endothelial dysfunction. Hyperhomocysteinemia affects endothelial function through various pathways, potentially serving as an important therapeutic target for cSVD.
FRONTIERS IN NEUROLOGY
(2021)
