Article
Chemistry, Medicinal
Alejandra Chavez-Riveros, Eduardo Hernandez-Vazquez, Angel Ramirez-Trinidad, Antonio Nieto-Camacho, Luis D. Miranda
Summary: In this study, an efficient two-step synthesis of diphenylamine-containing dipeptides was demonstrated, with fluorinated compound 10k showing promising anti-inflammatory activity, no cytotoxicity against murine cells, and minimal toxicity in Artemia salina.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Imran Khan, Debasish Kumar Dey, Jai-Heon Lee, Sun Chul Kang
Summary: In this study, the effects of SCN leaf extract on ear inflammation were investigated. The results showed that SCN could effectively suppress TPA-induced ear edema by modulating the MAP kinase signaling pathway and NF-kappa B activation. Overall, SCN may prove to be a useful therapeutic agent against skin inflammation.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fatin Jannus, Marta Medina-O'Donnell, Veronika E. Neubrand, Milagros Marin, Maria J. Saez-Lara, M. Rosario Sepulveda, Eva E. Rufino-Palomares, Antonio Martinez, Jose A. Lupianez, Andres Parra, Francisco Rivas, Fernando J. Reyes-Zurita
Summary: Recent evidence suggests that inflammation may contribute to tumorigenic states. The anti-inflammatory effects of OADP have been investigated both in vitro and in vivo, showing potential in inhibiting cytokine expression and blocking inflammatory signaling pathways. The development of OADP as a powerful anti-inflammatory agent could present an effective therapeutic strategy against inflammation and tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Priscila de Lima Paula, Ari Sergio de Oliveira Lemos, Lara Melo Campos, Thayna Gomes Ferreira, Thalita Freitas de Souza, Lucas Sales Queiroz, Maria Clara Machado Resende Guedes, Mario Machado Martins, Luiz Ricardo Goulart Filho, Gilson Costa Macedo, Guilherme Diniz Tavares, Vinicius Novaes Rocha, Angelo Marcio Leite Denadai, Rodrigo Luiz Fabri
Summary: This study investigated the antioxidant and anti-inflammatory potential of Plinia cauliflora leaves and branches extracts, confirming their effectiveness through chemical analysis and experimental assays on oxidation pathways and nitric oxide production.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Emanuele P. Lima, Odinei H. Goncalves, Franciele Q. Ames, Lidiane V. Castro-Hoshino, Fernanda V. Leimann, Roberto K. N. Cuman, Jurandir F. Comar, Ciomar A. Bersani-Amado
Summary: The study found that nanoencapsulated curcuminoid preparations and free curcuminoids had similar anti-inflammatory effects in topical treatment, while oral administration of nanoencapsulated curcuminoid preparations had a higher anti-inflammatory effect than free curcuminoids. Additionally, nanoencapsulated curcuminoid preparations showed better bioavailability compared to free curcuminoids.
Article
Biochemistry & Molecular Biology
Taghrid S. AlOmar, Abdur Rauf, Umer Rashid, Sehrish Sarfaraz, Khurshid Ayub, Fahad Hussain, Najla Almasoud, Abdulaziz S. AlOmar, Gauhar Rehman, Zubair Ahmad, Naveed Muhammad, Zafar Ali Shah
Summary: This study evaluates the anti-inflammatory potential of peshawaraquinone, a compound isolated from Fernandoa adenophylla, and investigates its mode of action. The results demonstrate significant anti-inflammatory activity of peshawaraquinone in both in vitro and in vivo models, supported by computational analyses. These findings provide a solid foundation for further exploration and therapeutic applications of peshawaraquinone.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Omolbanin Shahraki, Mohaddeseh Shayganpour, Mahmoud Hashemzaei, Sara Daneshmand
Summary: In this study, a novel formulation of HESP loaded solid lipid nanoparticles (SLNs) was developed to improve the solubility and bioavailability. The optimized formulation showed high encapsulation efficiency and small size, and exhibited improved anti-inflammatory potential of HESP.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Haile Tazeze, Solomon Mequanente, Dereje Nigussie, Belete Legesse, Eyasu Makonnen, Teklie Mengie
Summary: The study showed that Aloe trigonantha leaf gel had significant wound healing and anti-inflammatory effects in rat models, supporting its traditional use. The data indicated the potential of Aloe trigonantha as a medicinal agent for wound healing and inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Plant Sciences
Meilian Yang, Yudan Wang, Zhifeng Fan, Qingwang Xue, Guy Sedar Singor Njateng, Yaping Liu, Jianxin Cao, Afsar Khan, Guiguang Cheng
Summary: The study identified 21 monoterpenoid indole alkaloids (MIAs) in MCTA, with aspidospermine- and quinolone-type alkaloids as major compounds. MCTA demonstrated significant anti-inflammatory effects by inhibiting the activation of NF-kappa B and MAPK pathways in both in vitro and in vivo assessments.
Article
Chemistry, Organic
Yasuki Soda, Yasukazu Sugiyama, Shunsei Sato, Kana Shibuya, Junya Saegusa, Tomoe Matagawa, Sayaka Kawano, Makoto Yoritate, Keisuke Fukaya, Daisuke Urabe, Takeshi Oishi, Kento Mori, Siro Simizu, Noritaka Chida, Takaaki Sato
Summary: A stereodivergent method for the synthesis of totally substituted butenolide and the synthesis of a series of stemoamide-type alkaloids with good anti-inflammatory activity and low cytotoxicity have been reported in this study.
SYNTHESIS-STUTTGART
(2023)
Article
Immunology
Yang Liu, Hua Fu, Li Zuo
Summary: The study demonstrates that Conbercept significantly reduces paw edema volume and arthritis index in CIA rats, and decreases serum levels of VEGF, TNF-alpha, and IL-6. Additionally, Conbercept inhibits xylene-induced ear edema, indicating its significant impact on acute and chronic inflammation.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Food Science & Technology
Ga Eun Woo, Min Ji Kim, Dong-Hyun Ahn
Summary: This study found that ethanolic extract of Sargassum confusum has anti-inflammatory activity without cytotoxicity. The extract can suppress the production of inflammatory factors by inhibiting the expression of COX-2 and iNOS, as well as the phosphorylation of transcription factors.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Eui Jeong Han, Hyun-Soo Kim, Kyungsook Jung, Kalu Kapuge Asanka Sanjeewa, Kalahe Hewage Iresha Nadeeka Madushani Herath, WonWoo Lee, Youngheun Jee, You-Jin Jeon, Jeongjun Lee, Taehee Kim, Ilekuttige Priyan Shanura Fernando, Ginnae Ahn
Summary: The study demonstrated that Sargassum horneri 70% ethanol extracts (SHE) has significant anti-inflammatory effects in both TNF-alpha/IFN-gamma-induced inflammation in HaCaT keratinocytes and TPA-induced ear edema in mice. Further research could potentially develop SHE as a food supplement/nutricosmetic to enhance protective effects against inflammatory skin diseases.
Article
Surgery
Yuki Hirano, Takaaki Konishi, Hidehiro Kaneko, Hidetaka Itoh, Satoru Matsuda, Hirofumi Kawakubo, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hiroyuki Daiko, Osamu Itano, Hideo Yasunaga, Yuko Kitagawa
Summary: The retrospective study found no association between early postoperative non-steroidal anti-inflammatory drug (NSAID) use and anastomotic leakage after oesophagectomy. The study analyzed a nationwide inpatient database of 39,418 patients and used various analysis methods to conclude that NSAID use did not increase the risk of complications.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Christophe Tratrat, Michelyne Haroun, Aliki Paparisva, Charalmpos Kamoutsis, Anthi Petrou, Antonis Gavalas, Phaedra Eleftheriou, Athina Geronikaki, Katharigatta N. Venugopala, Hafedh Kochkar, Anroop B. Nair
Summary: A variety of compounds with good anti-inflammatory properties were synthesized and experimentally evaluated, with eleven of them showing equal or superior action compared to indomethacin. While some compounds had no or low inhibitory effects on COX-1/2 or LOX, certain compounds exhibited significantly higher COX-1 inhibition than naproxen.
Article
Clinical Neurology
Nicole Pages, Pierre Maurois, Pierre Bac, Sergio Meza-Toledo, Javier Peralta-Cruz, German Chamorro-Cevallos, Jose Melesio Cristobal-Luna, Joseph Vamecq
Summary: HEPP and Cl-HEPP demonstrate anti-seizure protection in mice against acute seizures at non-toxic doses, likely through their MGBR antagonistic properties. Other mechanisms may also be involved, particularly in providing protection in the MES test. The modulation of MDDAS components by these drugs shows similarities with ethosuximide.
Article
Environmental Sciences
Ricardo Ivan Montano-Gonzalez, Gabriela Gutierrez-Salmean, Maria Angelica Mojica-Villegas, Jose Melesio Cristobal-Luna, Jorge Briseno-Bugarin, German Chamorro-Cevallos
Summary: Spirulina and phycobiliproteins have been found to alleviate Cd-induced oxidative damage on the male reproductive system, improving sperm quality and protecting testes from oxidative stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Organic
Carlos H. Escalante, Fernando A. Carmona-Hernandez, Alberto Hernandez-Lopez, Eder Martinez-Mora, Francisco Delgado, Joaquin Tamariz
Summary: The straightforward synthesis of indolizines and pyrrolo[1,2-a]pyrazines was achieved through a cascade condensation/cyclization/aromatization reaction. The reaction proceeded satisfactorily under basic conditions, providing high yields of the desired products. N-Allenyl-2-formylpyrroles were found to be more reactive substrates compared to 2-formyl-N-propargylpyrroles in this reaction system.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Plant Sciences
Aurelio Nieto-Trujillo, Francisco Cruz-Sosa, Rosendo Luria-Perez, Gabriel Alfonso Gutierrez-Rebolledo, Angelica Roman-Guerrero, Cristina Burrola-Aguilar, Carmen Zepeda-Gomez, Maria Elena Estrada-Zuniga
Summary: Arnica montana cell suspension culture can be a sustainable source of plant material with bioactive secondary metabolites. The use of different plant growth regulator concentrations influences the total content of SMs, with the best yield achieved within 30 days. Fractionation of methanolic extracts resulted in three fractions with varying bioactivities and total SMs contents.
Article
Chemistry, Medicinal
Alberto Feliciano, Omar Gomez-Garcia, Carlos H. Escalante, Mario A. Rodriguez-Hernandez, Mariana Vargas-Fuentes, Dulce Andrade-Pavon, Lourdes Villa-Tanaca, Cecilio Alvarez-Toledano, Maria Teresa Ramirez-Apan, Miguel A. Vazquez, Joaquin Tamariz, Francisco Delgado
Summary: This study synthesized a series of chromenes compounds and evaluated their anticancer and antifungal activities. Some of the compounds showed higher activity against SK-LU-1 and PC-3 cells, as well as potential antifungal properties. Molecular docking studies revealed their interactions with key enzymes involved in cancer and fungal cell growth.
Review
Biology
Nancy Vargas-Mendoza, Marcelo Angeles-Valencia, Angel Morales-Gonzalez, Eduardo Osiris Madrigal-Santillan, Mauricio Morales-Martinez, Eduardo Madrigal-Bujaidar, Isela alvarez-Gonzalez, Jose Gutierrez-Salinas, Cesar Esquivel-Chirino, German Chamorro-Cevallos, Jose Melesio Cristobal-Luna, Jose A. Morales-Gonzalez
Summary: Exercise increases energy demand in cells, leading to mitochondrial stress and oxidative damage, while also playing a necessary role in maintaining cell signaling and homeostasis. Mitochondrial biogenesis is influenced by exercise through continuous crosstalk with the nuclear genome, and the potential impact of nutrients such as antioxidants on exercise performance warrants further investigation.
Article
Chemistry, Organic
Edson Barrera, R. Israel Hernandez-Benitez, Carlos A. Gonzalez-Gonzalez, Carlos H. Escalante, Aydee Fuentes-Benites, Carlos Gonzalez-Romero, Elvia Becerra-Martinez, Francisco Delgado, Joaquin Tamariz
Summary: New and efficient strategies for the conversion of 4-oxazolin-2-ones into 1-methyl and 1,4-dimethyl 3-formylcarbazoles are described. The diarylamines were obtained in high overall yields through highly convergent cascade and one-pot processes. The synthesis of methylated carbazoles by reacting 4,5-dimethyl-4-oxazolin-2-ones with enones under microwave irradiation was given special attention. The carbazole scaffold was provided by the palladium(II)-catalyzed double C-H activation to generate oxidative cyclization of diarylamines. This methodology allowed for formal total syntheses of four naturally occurring pyrido[4,3-b]carbazole alkaloids ellipticine, 9-methoxyellipticine, olivacine, and 9-methoxyolivacine.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Microbiology
Damian A. Madrigal-Aguilar, Adilene Gonzalez-Silva, Blanca Rosales-Acosta, Celia Bautista-Crescencio, Jossue Ortiz-Alvarez, Carlos H. Escalante, Jaime Sanchez-Navarrete, Cesar Hernandez-Rodriguez, German Chamorro-Cevallos, Joaquin Tamariz, Lourdes Villa-Tanaca
Summary: Due to the emergence of multidrug-resistant strains of yeasts, discovering antifungal agents that target alternative molecular targets is urgently needed. This study evaluated the capacity of three different series of synthetic compounds to inhibit a specific enzyme in Candida glabrata, leading to the disruption of ergosterol synthesis and yeast viability. Two compounds, 1c and 5b, were identified as the best antifungal candidates among the compounds studied. They effectively inhibited the growth of fluconazole-resistant and fluconazole-susceptible C. glabrata strains. The compounds act by inhibiting the mevalonate synthesis pathway, resulting in a decrease in ergosterol concentration. The docking analysis suggested that their inhibitory effect may be mediated by their interaction with the enzyme's catalytic site. Further research and modifications to increase their specificity and potency are needed.
MICROBIOLOGY SPECTRUM
(2022)
Review
Plant Sciences
German Chamorro-Cevallos, Maria Angelica Mojica-Villegas, Yuliana Garcia-Martinez, Salud Perez-Gutierrez, Eduardo Madrigal-Santillan, Nancy Vargas-Mendoza, Jose A. Morales-Gonzalez, Jose Melesio Cristobal-Luna
Summary: The use of medicinal plants in Mexico is crucial for treating diseases among the economically vulnerable population, but there are potential risks of teratogenic effects from certain plants, especially affecting the nervous system and axial skeleton. Research shows that approximately 0.22% of Mexican plants have teratogenic effects, indicating a need for more evaluation in this area.
Article
Chemistry, Organic
Daniel Yescas-Galicia, Rodrigo A. Restrepo-Osorio, Ailyn N. Garcia-Gonzalez, Roberto Hernandez-Benitez, Jose C. Espinoza-Hicks, Carlos H. Escalante, Edson Barrera, Blanca M. Santoyo, Francisco Delgado, Joaquin Tamariz
Summary: Palladium-catalyzed functionalization was performed on two building blocks, leading to the synthesis of a variety of compounds with different functional groups. These methods have been applied in the synthesis of a new derivative of ellipticine.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Eduardo Osel Olvera-Roldan, Jose Melesio Cristobal-Luna, Yuliana Garcia-Martinez, Maria Angelica Mojica-Villegas, Ricardo Perez-Pasten-Borja, Gabriela Gutierrez-Salmean, Salud Perez-Gutierrez, Rosa Virginia Garcia-Rodriguez, Eduardo Madrigal-Santillan, Jose A. Morales-Gonzalez, German Chamorro-Cevallos
Summary: The study aimed to evaluate the effects of Spirulina maxima on diabetic male rats in terms of body weight, glycemia, sexual behavior, sperm quality, testosterone levels, sex organ weights, and the activity of antioxidant enzymes. The results showed that Spirulina maxima significantly improved sexual behavior and sperm quality in diabetic animals.
Article
Biochemistry & Molecular Biology
Diter Miranda-Sanchez, Carlos H. Escalante, Dulce Andrade-Pavon, Omar Gomez-Garcia, Edson Barrera, Lourdes Villa-Tanaca, Francisco Delgado, Joaquin Tamariz
Summary: In this study, pyrrolo[1,2-a]pyrazines were synthesized by cyclization of 2-formylpyrrole-based enaminones. The synthesized compounds showed a strong antifungal effect on Candida species, including multidrug-resistant strains.
Article
Plant Sciences
Eira Santiago-Balmaseda, David Segura-Cobos, Maria Eugenia Garin-Aguilar, Ruben San Miguel-Chavez, Jose Melesio Cristobal-Luna, Eduardo Madrigal-Santillan, Gabriel Alfonso Gutierrez-Rebolledo, German Alberto Chamorro-Cevallos, Ricardo Perez-Pasten-Borja
Summary: The methanolic extract of C. pentadactylon flowers improves renal function through antioxidant mechanisms in experimental diabetes. The lower dose of the extract showed the best antioxidant effect by increasing catalase activity and reducing lipid peroxidation in the kidneys.