Review
Behavioral Sciences
Lucia Amendola, Daniel Weary, Gosia Zobel
Summary: Individual variation in responses to anxiety and spatial memory tests is often reported. These variations are related to consistent individual differences in behavior (personality). However, personality differences are rarely considered in anxiety treatment studies. This article focuses on rat literature to describe principles in anxiety and spatial memory tests and discusses the influence of personality and housing conditions on behavioral responses. The authors propose that environmental enrichment can enhance stress resiliency in environmentally sensitive individuals. Incorporating personality measures into study design and analysis can improve research reproducibility.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemical Research Methods
A. J. D. O. Cerveira, B. A. C. Ramalho, C. C. B. de Souza, A. P. Spadaro, B. A. Ramos, L. Wichert-Ana, F. E. Padovan-Neto, K. J. C. C. de Lacerda
Summary: This article describes a protocol for automated analysis of mouse behavior. The results show that automated analysis produces similar results to manual analysis, but with the advantages of saving time and reducing human errors.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Behavioral Sciences
Shun-Yu Zhang, Sheng-Qiang Chen, Jin-Yuan Zhang, Chang-Hui Chen, Xiao-Jun Xiang, Hui-Ru Cai, Song-Lin Ding
Summary: This study reveals that bilateral lesions of the prostriata significantly reduce spatial learning and memory abilities in rats, as well as decrease interest in spatial exploration and increase anxiety. However, the exercise capacity of the rats is not affected.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Hafiz Muhammad Abdur Rahman, Sana Javaid, Waseem Ashraf, Muhammad Fawad Rasool, Hammad Saleem, Salman Ali Khan, Zaheer Ul-Haq, Syed Muhammad Muneeb Anjum, Tanveer Ahmad, Faleh Alqahtani, Anees Ur Rehman, Imran Imran
Summary: This study aimed to evaluate the neuroprotective potential of methanolic extract Ailanthus altissima (AA) bark, which was found to be rich in phenols/flavonoids and showed antioxidative properties. The results of animal experiments demonstrated the sedative, anxiolytic, and memory-enhancing effects of AA, as well as its antioxidant activity through inhibition of acetylcholinesterase and reduction of malondialdehyde levels in the brain. These findings suggest that Ailanthus altissima bark may be a source of bioactive phytochemicals with neuroprotective potential.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Syed Mohammad Danish, Anshul Gupta, Urooj Ahmad Khan, Nazeer Hasan, Farhan Jalees Ahmad, Musarrat Husain Warsi, Ahmed M. Abdelhaleem Ali, Ameeduzzafar Zafar, Gaurav Kumar Jain
Summary: Intranasal cerium oxide nanoparticles (CNPs) have the potential to improve cognitive function in Alzheimer's disease (AD) through their antioxidant effect.
Review
Behavioral Sciences
Tingting Lv, Mengfei Ye, Fangyi Luo, Baiqi Hu, Anzhe Wang, Jiaqi Chen, Junwei Yan, Ziyi He, Feng Chen, Chao Qian, Jian Zhang, Zheng Liu, Zhinan Ding
Summary: The gut-brain axis and the concept of psychobiotics have drawn attention for their potential positive effects on cognitive function. Probiotics supplementation enhanced cognitive function, with a greater effect observed in cognitively impaired individuals. Single strains of probiotics were more effective in human studies, suggesting a customized approach may be beneficial for improving cognitive disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Keke Luo, Jiao Chen, Hui Li, Dirong Wu, Yuanjiang Du, Shanshan Zhao, Ting Liu, Li Li, Zeqin Dai, Yongjun Li, Yonglong Zhao, Lei Tang, Xiaozhong Fu
Summary: Scutellarein hybrids were designed, synthesized and evaluated as multifunctional therapeutic agents for the treatment of Alzheimer's disease (AD). Compound 11e exhibited strong inhibition of acetylcholinesterase enzymes, as well as effective aggregation inhibition and fibril disassembly of Aβ. It also showed good inhibition of tau protein hyperphosphorylation and platelet aggregation, as well as neuroprotective effects and optimal blood-brain barrier and intestinal absorption characteristics. In vivo studies demonstrated significant improvement in learning and memory impairment, with no safety concerns.
BIOORGANIC CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Lian Jingxuan, Ma Litian, Tu Yanyang, Fu Jianfang
Summary: This study investigates the changes and roles of CLC-3 in diabetic encephalopathy, suggesting that CLC-3 may regulate insulin receptor signaling and downstream PI3K/AKT/GSK3 ss signaling pathways, ultimately affecting the pathogenesis of the disease.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Environmental Sciences
Jie Li, Longying Zhang, Jiaqi Wang, Ruxue Jia, Xiao Zhang, Xiaojing Li, Ying Fu, Laiyu Song
Summary: By examining the expression of mRNAs and lncRNAs in the hippocampus, it was found that genes related to PM2.5 exposure were dysregulated, with microglia-related lncRNAs potentially playing a crucial role in the development of learning and memory deficits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komaki
Summary: This study investigated the effects of minocycline on cognitive abilities, antioxidant enzyme activities, neuronal loss, and plaque number in rats with Alzheimer's disease induced by Aβ. The results showed that minocycline improved anxiety behavior, restored learning and memory deficits, and had antioxidant and anti-apoptotic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Marta Balietti, Arianna Pugliese, Fiorenzo Conti
Summary: It has been demonstrated that cognitive stimulation in late life can prevent cognitive decline in still cognitively preserved animals and improve cognitive compromised animals. Future research should focus on individually tailored stimulation protocols to enhance their effectiveness.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Veronika Rudolfova, Tomas Petrasek, Eliska Antosova, Daniel Frynta, Eva Landova, Karel Vales, Tereza Nekovarova
Summary: This study tested the repeatability of behavior in the Long Evans strain of laboratory rats and found stable inter-individual differences in behavior, but no evidence of a behavioral syndrome.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Nagat El-Demerdash, Tiffany Pan, Olivia Choi, Manda Saraswati, Raymond C. Koehler, Courtney L. Robertson, Alena Savonenko
Summary: Therapies for pediatric traumatic brain injury (TBI), especially in young children, are limited and can result in long-term consequences. Animal models have provided insights into the mechanisms of pediatric TBI, but it is challenging to demonstrate clinically relevant long-term behavioral and cognitive deficits. This study used a controlled cortical impact (CCI) model of pediatric TBI to assess short- and long-term outcomes through a series of tests. The results showed functional impairments in most tests for TBI rats compared to control groups, particularly in cognitive processes related to fast one-trial learning, memory flexibility, response strategies, and recognition memory in social interactions.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Neurosciences
Yan Zhao, Yizhou Zhang, Sijia Meng, Bingyu Chen, Xinyi Dong, Xiaojing Guo, Fangzhen Guo, Runjiao Zhang, Huixian Cui, Sha Li
Summary: A systematic review and meta-analysis found no significant improvement in cognitive function with S-adenosylmethionine (SAM) supplementation. Further studies are needed to assess the effectiveness of SAM supplementation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Leila Karimi-Zandi, Maryam Zahmatkesh, Gholamreza Hassanzadeh, Soheila Hosseinzadeh
Summary: This study found an increase in fractalkine-positive microvesicles in the early stages of Alzheimer's disease, suggesting their potential as a biomarker for early diagnosis.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)