Article
Multidisciplinary Sciences
Steven M. Van Belleghem, Angelo A. Ruggieri, Carolina Concha, Luca Livraghi, Laura Hebberecht, Edgardo Santiago Rivera, James G. Ogilvie, Joseph J. Hanly, Ian A. Warren, Silvia Planas, Yadira Ortiz-Ruiz, Robert Reed, James J. Lewis, Chris D. Jiggins, Brian A. Counterman, W. Owen McMillan, Riccardo Papa
Summary: Little is known about the use of homologous regulatory architectures for phenotypic convergence in species. This study characterizes the regulatory architecture of wing pattern convergence in mimetic butterfly species and finds that different mutational paths are involved in integrating color pattern genes. The findings suggest a high level of developmental drift and evolutionary contingency in the independent evolution of mimicry.
Article
Biochemistry & Molecular Biology
Benjamin Rein, Tao Tan, Fengwei Yang, Wei Wang, Jamal Williams, Freddy Zhang, Alea Mills, Zhen Yan
Summary: 16p11.2 duplication mice show social and cognitive deficits similar to ASD and ID, but not schizophrenia-related symptoms. The study suggests that prefrontal cortical GABAergic synaptic circuitry and Npas4 play crucial roles in 16p11.2 duplication pathology, representing potential therapeutic targets for ASD intervention.
MOLECULAR PSYCHIATRY
(2021)
Article
Genetics & Heredity
Amy E. Clipperton-Allen, Angela Zhang, Ori S. Cohen, Damon Theron Page
Summary: The study demonstrated that exposing Pten(+/-) mice to environmental enrichment after brain overgrowth occurred can improve their social behavioral deficits and partially ameliorate repetitive behavior deficits. Environmental enrichment restored the abnormal levels of excitatory and inhibitory presynaptic proteins in Pten(+/-) mice.
Article
Multidisciplinary Sciences
Suzanne O. Nolan, Samantha L. Hodges, Matthew S. Binder, Gregory D. Smith, James T. Okoh, Taylor S. Jefferson, Brianna Escobar, Joaquin N. Lugo
Summary: This study aimed to investigate the therapeutic efficacy of omega-3 fatty acids for the behavioral and neuroimmune phenotype of the Fmr1 knockout model. The results showed that omega-3 fatty acid supplementation reversed certain behavioral deficits but also had negative effects on other behaviors and immune functions.
Article
Economics
Carolyn E. Schwartz, Roland B. Stark, Wesley Michael, Bruce D. Rapkin, Joel A. Finkelstein
Summary: The study found that GAC scores primarily reflect changes in the physical domain, as well as individuals' attributions, goals, and emphasis related to changes in health and healthcare. Factors that are commonly unmeasured also have an impact on GAC scores, facilitating the interpretation of change.
Article
Business, Finance
Andrew Urquhart
Summary: This paper provides a detailed overview of the Ethereum blockchain, and conducts research on this cryptocurrency by analyzing addresses, transactions, fees, and user holding patterns.
FINANCE RESEARCH LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Qian Wang, Meng-wei Wang, Yan-yun Sun, Xiao-yan Hu, Pan-pan Geng, Hui Shu, Xiao-na Wang, Hao Wang, Jun-fang Zhang, Hong-qiang Cheng, Wei Wang, Xin-chun Jin
Summary: Increasing evidence suggests that chronic nicotine treatment can alleviate MK-801-induced schizophrenia-like symptoms and cognitive impairment in mice. This study found that nicotine treatment reversed the increased expression levels of PDZ and LIM domain 5 (Pdlim5) and prevented the decrease in CREB-regulated transcription coactivator 1 (CRTC1) in the prefrontal cortex (PFC), resulting in improved cognition in mice.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Mohammed M. Alanazi, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Haneen A. Al-Mazroua, Abdullah A. Aldossari, Mohammed M. Almutairi, Thamer H. Albekairi, Marwa H. Hussein, Mohammed A. Al-Hamamah, Sheikh F. Ahmad
Summary: This study found that cadmium exposure exacerbates self-grooming and marble-burying behaviors, decreases social interactions, and leads to immune abnormalities in an autism spectrum disorder animal model. Further investigation revealed potential molecular mechanisms underlying these effects. These findings have important implications for the etiology of autism spectrum disorders and provide further evidence of heavy metals contributing to neurodevelopmental disorders through proinflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Yuen Gao, Mohammad B. Aljazi, Jin He
Summary: This study reveals a potential causal link between disruptive KDM6B mutations and ASD/ADHD-like behavioral deficits using an animal model. It also provides a new mouse model for studying the cellular and molecular mechanisms underlying Kdm6b-mutation-related neurodevelopmental disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Cell Biology
Seongbin Kim, Hyoseon Oh, Sang Han Choi, Ye-Eun Yoo, Young Woo Noh, Yisul Cho, Geun Ho Im, Chanhee Lee, Yusang Oh, Esther Yang, Gyuri Kim, Won-Suk Chung, Hyun Kim, Hyojin Kang, Yongchul Bae, Seong-Gi Kim, Eunjoon Kim
Summary: In this study, researchers found that Myt1l deficiency in mice leads to autism-related phenotypes, which exhibit age-dependent characteristics. The study also suggests that while the reduction of Myt1l expression in juveniles temporarily improves these phenotypes, they reappear in adults.
Review
Biochemical Research Methods
Alan T. Stone, Venkata Gayatri Dhara, Harnish Mukesh Naik, Lateef Aliyu, Junxi Lai, Jackson Jenkins, Michael J. Betenbaugh
Summary: Upstream process development focuses on optimizing media formulations to enhance cell culture conditions and regulate product quality attributes. Transition metal ions in cell culture media, such as Mn, Fe, Cu, and Zn, have significant impacts on cell growth, metabolism, and product quality, but their associations and effects are not well characterized. Equilibrium models can be used to explore metal speciation, but experimental determination of equilibrium constants and consideration of reaction kinetics are also necessary to fully understand the complex interactions between media components and bioprocess performance.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Editorial Material
Biology
Guillaume Romet-Lemonne
Summary: Experiments using purified proteins show that the network of filaments underlying cell movement becomes denser when pushed against a stronger mechanical force.
Review
Neurosciences
Ana I. Silva, Friederike Ehrhart, Magnus O. Ulfarsson, Hreinn Stefansson, Kari Stefansson, Lawrence S. Wilkinson, Jeremy Hall, David E. J. Linden
Summary: Genomic copy number variants (CNVs) are associated with a high risk of neurodevelopmental disorders, and these high-risk genetic variants converge in common molecular pathways. Studies have shown that different CNVs have similar effects on core sensory, cognitive, and motor traits. Neuroimaging studies have provided valuable information on how CNVs affect brain structure and function. However, most studies only examine one CNV at a time, making it difficult to fully understand the extent of shared brain effects.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Computer Science, Artificial Intelligence
Luca Franco, Leonardo Placidi, Francesco Giuliari, Irtiza Hasan, Marco Cristani, Fabio Galasso
Summary: Transformer Networks have been widely recognized as the state-of-the-art for trajectory forecasting. However, there is a lack of systematic study on their capability to model individual motion patterns without interactions or social context. This paper presents the first in-depth study of Transformer Networks and Bidirectional Transformers for forecasting individual motion, focusing on plain sequence models. The results show that both TF and BERT perform well in predicting individual motions and achieve comparable results to more complex techniques incorporating social interactions and scene contexts. Source code for all experiments will be made available.
PATTERN RECOGNITION
(2023)
Article
Psychiatry
Kaijie Ma, Connie Taylor, Mark Williamson, Samuel S. S. Newton, Luye Qin
Summary: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic heterogeneity and more prevalent in males than females. Recent research suggests that diminished activity-dependent neural signaling, specifically brain-derived neurotrophic factor (BDNF) signaling, is a key factor in ASD. This study investigates the effect of diminished activity-dependent BDNF signaling on autism-like behavioral deficits, and confirms its causal link with ASD.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)
