Article
Cell Biology
Meiyu Piao, Sung Ho Lee, Yuankuan Li, Joong-Kook Choi, Chang-Yeol Yeo, Kwang Youl Lee
Summary: This study reveals the positive impact of CypE on osteoblast differentiation by enhancing the transcriptional activity of Runx2 through its PPIase activity. The involvement of the Akt signaling pathway in CypE's function in osteoblast differentiation is also identified.
Review
Biochemistry & Molecular Biology
Toshihisa Komori
Summary: Runx2 is a crucial transcription factor in bone development, playing a key role in the maturation and proliferation of chondrocytes and osteoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Ran Park, SooHyun Kim, MyoungLae Cho, Hyung-Mun Yun
Summary: The study demonstrates that obacunone promotes osteoblast differentiation and bone mineralization through various biological activities and signaling pathways, including enhancing early and late osteoblast differentiation, activating BMP2 and beta-catenin, inhibiting GSK3 beta, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jianglei Chen, Yi Lin, Zhongjie Sun
Summary: This study investigates the role of miR-101-3p in calcific aortic valve disease. The results show that miR-101-3p promotes calcification and upregulates the osteogenesis pathway, while inhibition of miR-101-3p prevents calcification. Mechanistically, miR-101-3p targets CDH11 and SOX9, key factors in chondrogenesis and osteogenesis regulation. This finding suggests that miR-101-3p may be a potential therapeutic target for calcific aortic valve disease.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
Summary: Paeonoside (PASI) isolated from Paeonia suffruticosa roots enhances osteoblast migration, early differentiation, and mineralized nodule formation by regulating RUNX2 expression through the BMP2 and Wnt3a pathways, suggesting a potential therapeutic role in treating bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Xiaoyan Zhang, Lijun Zhang, Liqun Xu, Gaozhi Li, Ke Wang, Tong Xue, Quan Sun, Hao Tang, Xinsheng Cao, Zebing Hu, Shu Zhang, Fei Shi
Summary: The secretion of exosomes with high expression of miR-92b-3p by microvascular endothelial cells (MVECs) under mechanical unloading conditions was found to inhibit the differentiation of MC3T3-E1 cells into mature osteoblasts. Further experiments showed that miR-92b-3p was transferred into MC3T3-E1 cells by exosomes, leading to the suppression of osteogenic differentiation. This discovery provides a potential strategy for studying and preventing mechanical unloading-induced bone loss and disuse osteoporosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Lijun Zhang, Liqun Xu, Yixuan Wang, Xiaoyan Zhang, Tong Xue, Quan Sun, Hao Tang, Meng Li, Xinsheng Cao, Fei Shi, Ge Zhang, Shu Zhang, Zebing Hu
Summary: Emerging evidence suggests that multiple mechanisms are involved in bone loss induced by mechanical unloading. A new study shows that histone modification plays a crucial role in osteogenic differentiation under mechanical unloading. The study demonstrated that Setdb1, a histone methyltransferase, is increased during osteogenic differentiation and its knockdown blocks osteoblast function. Further investigation revealed that Setdb1 inhibits the expression of miR-212-3p, which suppresses osteogenic differentiation by downregulating Hmgb1 expression. These findings highlight the potential of the Setdb1/miR-212-3p/Hmgb1 pathway as a protective strategy against bone loss induced by mechanical unloading.
CELLULAR SIGNALLING
(2023)
Article
Biotechnology & Applied Microbiology
Yun Jiang, Wei Ji, Jiaqi Zhu, Zihao Shen, Jianle Chen
Summary: The development of calcific aortic valve disease (CAVD) is a complex process of ectopic calcification, and miR-664a-3p may be a potential therapeutic target for regulating osteogenic differentiation in AVICs.
Article
Biochemistry & Molecular Biology
Hyo-Eun Son, Won-Gu Jang
Summary: This study reveals that Cip2A plays a critical role in regulating osteoblast differentiation by inducing ERK phosphorylation in MG63 cells.
Article
Food Science & Technology
Kyung-Ran Park, Yoon-Ju Kwon, Yun Hee Jeong, Jin Tae Hong, Hyung-Mun Yun
Summary: In this study, it was found that Thel extracted from Polyozellus multiplex can promote osteoblast differentiation and bone matrix mineralization. Thel also regulates the expression of RUNX2 and MMP13, suggesting its potential as a therapeutic agent for bone disorders.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Genetics & Heredity
Dandan Liu, Yang Liu, XianLi Zhang, Yixiang Wang, Chenying Zhang, Shuguo Zheng
Summary: Some CCD patients do not present mutations related to RUNX2, suggesting that other unknown gene variations may contribute to the condition. This study suggests that a mutation in the IGSF10 gene might be associated with CCD, leading to skeletal development abnormalities.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Jianmei Chen, Di Liu, Bo Chen, Yang Yang, Hongying Zhu, Danyang Li, Kun Liu, Lina Zhu, Hongrui Liu, Minqi Li, Xu Zhang, Xiangzhi Li
Summary: Mof plays a role in promoting osteoblast differentiation by increasing the expression of Runx2 and Osterix through histone H4K16 acetylation. Mof also directly interacts with Runx2 and Osterix to further enhance osteoblast differentiation.
CELL AND TISSUE RESEARCH
(2023)
Article
Cell Biology
Jun Mi, Shuangshuang Wang, Panpan Liu, Chang Liu, Dexuan Zhuang, Xue Leng, Qun Zhang, Fuxiang Bai, Qiang Feng, Xunwei Wu
Summary: Periodontal ligament stem cells (PDLSCs) are a type of cells with self-renewal capability and multidirectional differentiation potential. This study reveals that CUL4B plays a role as a new regulator in the osteogenic differentiation of PDLSCs. It cooperates with the PRC2 complex to repress the expression of miR-320c and miR-372/373-3p, leading to the upregulation of RUNX2, a master transcription factor (TF) that regulates osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Kuaitian Wang, Xiao Kong, Mengdi Du, Wei Yu, Zhenhua Wang, Bo Xu, Jianrong Yang, Jingru Xu, Zhili Liu, Yongqiang Cheng, Jing Gan
Summary: The calcium-binding peptide DEDEQIPSHPPR derived from soy yogurt was found to stimulate osteoblast differentiation and bone mineralization through the activation of the RUNX2 via the T beta RI-p38-MAPK signaling pathways. These findings highlight the potential of CBP in treating osteoporosis.
Article
Cell Biology
Hyung-Mun Yun, Bomi Kim, Ji Eun Park, Kyung-Ran Park
Summary: In this study, the bioactive compound trifloroside (TriFs) isolated from Gentianae Scabrae Radix was found to promote osteogenic activity and mineral apposition in pre-osteoblast cells. TriFs stimulated the major osteogenic BMP2-Smad1/5/8-RUNX2 pathway and increased cell migration and adhesion. This suggests that TriFs has potential as a drug target for osteoblast-mediated bone diseases.
Article
Neurosciences
Changyang Xing, Xinpei Wang, Yuan Gao, Jiaxin Zhang, Yunnan Liu, Yitong Guo, Chen Wang, Yang Feng, Yujia Lei, Xing Zhang, Jia Li, Wendong Hu, Shu Zhang, Lijun Yuan, Feng Gao
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Cell Biology
Zhongyang Sun, Han Wang, Yuxiang Wang, Guodong Yuan, Xin Yu, Hui Jiang, Qi Wu, Binkui Yang, Zebing Hu, Fei Shi, Xinsheng Cao, Shu Zhang, Ting Guo, Jianning Zhao
Summary: The study identified the miR-103-3p/METTL14/m(6)A signaling axis as a critical regulator of osteoblast activity, with miR-103-3p targeting Mettl14 to inhibit osteoblast function and METTL14 promoting osteoblast activity through m(6)A methylation of miR-103-3p. Therapeutic inhibition of miR-103-3p reversed the decreased bone formation, indicating the potential of this signaling axis as a target for ameliorating osteoporosis.
Article
Multidisciplinary Sciences
Jingjing Dong, Honghui Wang, Gaozhi Li, Ke Wang, Yingjun Tan, Lijun Zhang, Yixuan Wang, Zebing Hu, Xinsheng Cao, Fei Shi, Shu Zhang
Summary: The combination of microgravity and radiation exacerbates the effects on MC3T3-E1 cells and rat femurs, leading to decreased cell activity, increased apoptosis rates, bone loss, and altered gene and protein expressions.
Article
Biochemistry & Molecular Biology
Honghui Wang, Jingjing Dong, Gaozhi Li, Yingjun Tan, Hai Zhao, Lijun Zhang, Yixuan Wang, Zebing Hu, Xinsheng Cao, Fei Shi, Shu Zhang
Summary: Experimental findings have shown that simulated microgravity or radiation can decrease MafG expression and increase apoptosis in MC3T3-E1 cells; meanwhile, increased ROS levels facilitate apoptosis in cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Physiology
Changyang Xing, Yuan Gao, Xinpei Wang, Wenjuan Xing, Yunnan Liu, Yujia Lei, Xing Zhang, Shu Zhang, Lijun Yuan, Feng Gao
Summary: Restricting blood flow in the thigh can effectively alleviate transient cerebral hypoperfusion induced by rapid shift from -Gz to + Gz, characterized by significant improvement in cerebral diastolic flow.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liqun Xu, Lijun Zhang, Xiaoyan Zhang, Gaozhi Li, Yixuan Wang, Jingjing Dong, Honghui Wang, Zebing Hu, Xinsheng Cao, Shu Zhang, Fei Shi
Summary: The study demonstrated for the first time that mechanical unloading inhibits proliferation of brain microvascular endothelial cells through the HDAC6/miR-155-5p/RHEB axis, indicating that this pathway could be a specific target for preventative treatment of cardiovascular deconditioning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yuanyuan Yu, Luyao Wang, Shuaijian Ni, Dijie Li, Jin Liu, Hang Yin Chu, Ning Zhang, Meiheng Sun, Nanxi Li, Qing Ren, Zhenjian Zhuo, Chuanxin Zhong, Duoli Xie, Yongshu Li, Zong-Kang Zhang, Huarui Zhang, Mei Li, Zhenlin Zhang, Lin Chen, Xiaohua Pan, Weibo Xia, Shu Zhang, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Summary: This study demonstrates that sclerostin has different mechanisms in protecting the cardiovascular system and inhibiting bone formation. By targeting sclerostin loop3, a drug can promote bone formation without affecting the cardiovascular system.
NATURE COMMUNICATIONS
(2022)
Article
Astronomy & Astrophysics
Liqun Xu, Xiaoyan Zhang, Gaozhi Li, Lijun Zhang, Shu Zhang, Fei Shi, Zebing Hu
Summary: In this study, it was found that miR-138-5p was upregulated under simulated microgravity, inhibiting osteoblast proliferation and promoting osteoblast apoptosis. Additionally, SIRT1 was downregulated and negatively correlated with miR-138-5p expression, suggesting that miR-138-5p inhibits osteoblast proliferation and promotes osteoblast apoptosis by targeting SIRT1. Therefore, the miR-138-5p/SIRT1 pathway should be considered for preventative treatment of disuse osteoporosis.
LIFE SCIENCES IN SPACE RESEARCH
(2023)
Article
Cell Biology
Lijun Zhang, Liqun Xu, Xiaoyan Zhang, Ke Wang, Yingjun Tan, Gaozhi Li, Yixuan Wang, Tong Xue, Quan Sun, Xinsheng Cao, Ge Zhang, Zebing Hu, Shu Zhang, Fei Shi
Summary: This study reveals for the first time the role of the Atf7ip/Setdb1/Macrod2 axis in osteoblast proliferation under mechanical unloading, providing a potential protective strategy against unloading-induced bone loss.
Article
Cell Biology
Lijun Zhang, Liqun Xu, Yixuan Wang, Xiaoyan Zhang, Tong Xue, Quan Sun, Hao Tang, Meng Li, Xinsheng Cao, Fei Shi, Ge Zhang, Shu Zhang, Zebing Hu
Summary: Emerging evidence suggests that multiple mechanisms are involved in bone loss induced by mechanical unloading. A new study shows that histone modification plays a crucial role in osteogenic differentiation under mechanical unloading. The study demonstrated that Setdb1, a histone methyltransferase, is increased during osteogenic differentiation and its knockdown blocks osteoblast function. Further investigation revealed that Setdb1 inhibits the expression of miR-212-3p, which suppresses osteogenic differentiation by downregulating Hmgb1 expression. These findings highlight the potential of the Setdb1/miR-212-3p/Hmgb1 pathway as a protective strategy against bone loss induced by mechanical unloading.
CELLULAR SIGNALLING
(2023)
Article
Genetics & Heredity
Xiaoyan Zhang, Tong Xue, Zebing Hu, Xian Guo, Gaozhi Li, Yixuan Wang, Lijun Zhang, Liqun Xu, Xinsheng Cao, Shu Zhang, Fei Shi, Ke Wang
Summary: This study identifies hub genes and explores novel molecular mechanisms underlying microgravity-induced bone loss, providing potential targets for countermeasures against this condition.
FRONTIERS IN GENETICS
(2022)
Article
Health Care Sciences & Services
Xiaoyan Zhang, Lijun Zhang, Liqun Xu, Gaozhi Li, Ke Wang, Tong Xue, Quan Sun, Hao Tang, Xinsheng Cao, Zebing Hu, Shu Zhang, Fei Shi
Summary: The secretion of exosomes with high expression of miR-92b-3p by microvascular endothelial cells (MVECs) under mechanical unloading conditions was found to inhibit the differentiation of MC3T3-E1 cells into mature osteoblasts. Further experiments showed that miR-92b-3p was transferred into MC3T3-E1 cells by exosomes, leading to the suppression of osteogenic differentiation. This discovery provides a potential strategy for studying and preventing mechanical unloading-induced bone loss and disuse osteoporosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Luyao Wang, Yuanyuan Yu, Shuaijian Ni, Dijie Li, Jin Liu, Duoli Xie, Hang Yin Chu, Qing Ren, Chuanxin Zhong, Ning Zhang, Nanxi Li, Meiheng Sun, Zong-Kang Zhang, Zhenjian Zhuo, Huarui Zhang, Shu Zhang, Mei Li, Weibo Xia, Zhenlin Zhang, Lin Chen, Peng Shang, Xiaohua Pan, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Summary: The sclerostin loop3-specific aptamer Apc001PE has been shown to promote bone formation without increasing cardiovascular risk in osteogenesis imperfecta (OI) mice, as granted orphan drug designation by US-FDA in 2019.
Review
Pharmacology & Pharmacy
Sifan Yu, Dijie Li, Ning Zhang, Shuaijian Ni, Meiheng Sun, Luyao Wang, Huan Xiao, Dingdong Liu, Jin Liu, Yuanyuan Yu, Zongkang Zhang, Samuel Tin Yui Yeung, Shu Zhang, Aiping Lu, Zhenlin Zhang, Baoting Zhang, Ge Zhang
Summary: Sclerostin, secreted by osteocytes, negatively regulates the WNT signaling pathway, inhibiting bone formation and promoting bone resorption. It is implicated in musculoskeletal diseases, cancers, obesity, and diabetes. Monoclonal antibodies, aptamers, and small-molecule inhibitors are inhibitors targeting sclerostin. The monoclonal antibody romosozumab, as the first-approved sclerostin inhibitor, effectively treats postmenopausal osteoporosis, but also poses cardiovascular risks.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Endocrinology & Metabolism
Yixuan Wang, Lijun Zhang, Ke Wang, Hua Zhou, Gaozhi Li, Liqun Xu, Zebing Hu, Xinsheng Cao, Fei Shi, Shu Zhang
Summary: This study observed reduced osteoblast number and bone formation in LPS-induced bone loss mice. The levels of circulating exosomes were increased and the expression of exosomal miRNAs was significantly changed in these mice. The increased exosomes inhibited the osteogenic differentiation of MC3T3-E1 cells.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)