Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Selcan Demir, Jessica Li, Laurence S. Magder, Michelle Petri
Summary: The study showed that LA remained the best predictor of thrombosis in SLE patients, and adding additional aPL did not increase the risk except for anti-beta(2)-glycoprotein I IgA.
Article
Rheumatology
L. Riancho-Zarrabeitia, V. Martinez-Taboada, I. Rua-Figueroa, F. Alonso, M. Galindo-Izquierdo, J. Ovalles, A. Olive-Marques, N. Mena Vazquez, J. Calvo-Alen, R. Menor-Almagro, E. Tomero-Muriel, E. Uriarte-Isacelaya, A. Botenau, M. Andres, M. Freire-Gonzalez, G. Santos Soler, E. Ruiz-Lucea, M. Ibanez-Barcelo, I. Castellvi, C. Galisteo, V. Quevedo Vila, E. Raya, J. Narvaez, L. Exposito, J. A. Hernandez-Beriain, L. Horcada, E. Aurrecoechea, J. M. Pego-Reigosa
Summary: The study found varying associations between different types of antiphospholipid antibodies and manifestations of SLE and APS. For example, the IgG isotypes were associated with a higher risk of more severe SLE manifestations. Moreover, the risk of neuropsychiatric and ophthalmological symptoms significantly increased with a higher number of positive aPL.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A. Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Matteo d'Alessandro, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri
Summary: The circulating anti-ENO1, anti-H2A, and anti-ANXA1 antibodies were associated with high proteinuria in lupus nephritis patients, with the anti-ENO1 antibody showing the maximum reduction within 12 months paralleling the decrease in proteinuria. Anti-dsDNA antibodies were not linked to renal outcome parameters. New IgG2 antibody signatures have the potential to be used as markers for personalized therapies in lupus nephritis.
Article
Immunology
Ch Lopez-Pedrera, A. M. Patino-Trives, T. Cerdo, R. Ortega-Castro, I. Sanchez-Pareja, A. Ibanez-Costa, L. Munoz-Barrera, M. C. Abalos-Aguilera, D. Ruiz-Vilchez, P. Segui Azpilcueta, M. Espinosa, N. Barbarroja, A. Escudero-Contreras, J. P. Castano, R. Luque, R. Ortega, M. A. Aguirre, C. Perez-Sanchez
Summary: This study characterized the splicing machinery (SM) of leukocytes from patients with primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), and antiphospholipid syndrome with lupus (APS + SLE), and assessed its clinical involvement. The results showed that leukocytes from APS, SLE, and APS + SLE patients displayed significant and specific alterations in SM-components (SMC), which were associated with clinical features. This study identified a specific alteration of SMC in leukocytes from APS, SLE, and APS + SLE patients, which may be responsible for the development of distinctive clinical profiles.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Immunology
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Diana M. Morales-Prieto, Ekkehard Schleussner, Gerard Espinosa, Nuria Banos
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that mainly affects women of childbearing age. During pregnancy, SLE is associated with a higher risk of perinatal morbidity and mortality. Several studies have suggested that placental dysfunction may play a crucial role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ines Bernardoff, Alexandre Picq, Pierre Loiseau, Thomas Foret, Virginie Dufrost, Thomas Moulinet, Ozan Unlu, Doruk Erkan, Denis Wahl, Stephane Zuily
Summary: This study conducted a systematic review and meta-analysis to evaluate the association of antiphospholipid antibodies (aPL) with autoimmune hemolytic anemia in systemic lupus erythematosus (SLE) patients. The results showed a strong association between the presence of aPL and the occurrence of hemolytic anemia in SLE patients, with lupus anticoagulant and anti beta 2Glycoprotein I antibodies having the highest risk. IgM isotypes also indicated an increased risk of hemolytic anemia in SLE.
AUTOIMMUNITY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Fan-Yu Chen, Chun-Fan Chen, Ann Charis Tan, Chia-Hao Chan, Fu-An Chen, Wen-Sheng Liu, Tz-Heng Chen, Shuo-Ming Ou, Szu-Yuan Li, Ming-Tsun Tsai, Yung-Tai Chen, Chih-Ching Lin
Summary: Patients with systemic lupus erythematosus (SLE) have a higher incidence of arteriovenous fistula or graft (AVF/AVG) dysfunction during long-term follow-up, necessitating regular monitoring to improve vascular access function.
SCIENTIFIC REPORTS
(2021)
Review
Rheumatology
Pierre Loiseau, Thomas Foret, Ersilia M. DeFilippis, Jessie Risse, Anais D. Etienne, Virginie Dufrost, Thomas Moulinet, Doruk Erkan, Herve Devilliers, Denis Wahl, Stephane Zuily
Summary: This meta-analysis demonstrates an increased risk of livedo in aPL-positive SLE patients compared to aPL-negative patients. For daily clinical practice, livedo associated with aPL in patients with SLE may represent a specific group with small vessel disease.
Review
Biochemistry & Molecular Biology
Ryo Hisada, Tatsuya Atsumi
Summary: Despite advances in treatment, thrombosis remains the leading cause of death in SLE. aPL are the main triggers of thrombosis in SLE patients, with a frequency of approximately 30-40%. Lupus anticoagulant, anticardiolipin, anti-beta 2-glycoprotein I antibodies, and non-criteria aPL are risk factors for thrombosis in SLE. Multiple positivity for aPL and calculated scores can predict the risk of thrombosis. Treatment with anticoagulants and/or low-dose aspirin may be appropriate for aPL-positive SLE patients.
Article
Medicine, Research & Experimental
Yanli Zeng, Yun Xiao, Fanxiang Zeng, Longcan Jiang, Shuidi Yan, Xuelian Wang, Qiaoduan Lin, Liang Yu, Xinxin Lu, Yan Zhang, Yiqiang Lin
Summary: This study aimed to investigate the levels of anti-nucleosome antibody (ANuA) isotypes in patients with systemic lupus erythematosus (SLE) and identify ANuA isotypes that can diagnose and predict SLE. The levels of three ANuA isotypes (IgG, IgA, and IgM) were significantly higher in SLE patients compared to patients with other autoimmune diseases and healthy controls. Furthermore, the levels of ANuA isotypes were positively correlated with SLE disease activity, high-avidity IgG ANAs, and serum anti-dsDNA IgG levels. ANuA isotypes showed high sensitivity and specificity for the diagnosis of SLE and lupus nephritis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Masahiro Nakano, Yukiko Iwasaki, Keishi Fujio
Summary: Studies on SLE have identified several disease-relevant signatures, including the IFN signature, myeloid lineage/neutrophil and plasma cell signatures, and the exhaustion signature in CD8(+) T cells, which are correlated with disease activity, nephritis, and complications of pregnancy. Further research is needed to identify treatment targets and patient stratification in SLE, as well as to understand the molecular heterogeneity and distinct subpopulations involved in the pathogenesis of SLE.
INFLAMMATION AND REGENERATION
(2021)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
