Article
Genetics & Heredity
Adam J. Lawther, Jerzy Zieba, Zhiming Fang, Teri M. Furlong, Illya Conn, Hemna Govindaraju, Laura L. Y. Choong, Nigel Turner, Khawar Sohail Siddiqui, Wallace Bridge, Sam Merlin, Tzipi Cohen Hyams, Murray Killingsworth, Valsamma Eapen, Raymond A. Clarke, Adam K. Walker
Summary: Mitochondrial dysfunction is strongly associated with autism spectrum disorder (ASD), and the IMMP2L gene is linked to autism inheritance. By developing an Immp2lKD knockout mouse model, the researchers found that Immp2l(KD) -/- KO mice did not show any differences in the core behavioral symptoms of ASD, but they exhibited increased auditory stimulus-driven instrumental behavior and amphetamine-induced locomotion. The researchers also discovered that the ROS levels were lowered in the new Immp2l(KD) -/- KO mice, contrary to previous studies on Immp2l-deficient mouse models, and these mice did not display oxidative stress-related phenotypes.
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: This study evaluated the prevalence, age of onset, and clinical correlates of blocking tics (BTs) in patients with Gilles de la Tourette syndrome (GTS). BTs represent early and common symptoms of GTS, associated with a more severe form of the syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Beatrice K. Leung, Sam Merlin, Adam K. Walker, Adam J. Lawther, George Paxions, Valsamma Eapen, Raymond Clarke, Bernard W. Balleine, Teri M. Furlong
Summary: This study suggests that the Immp2l gene may contribute to the core symptoms of ASD and GTS, such as tics and repetitive behaviors. However, it does not have an impact on goal-directed and habitual actions. Instead, it may increase the responsiveness to external stimuli, potentially influencing the expression of tics and repetitive behaviors.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neuroimaging
Alexander Muenchau, Lorenza S. Colzato, Azam AghajaniAfjedi, Christian Beste
Summary: This paper proposes an exploration of the characteristics and potential explanations of Tourette syndrome, focusing on neural noise and its adaptation in information processing. Through neurophysiological and imaging approaches, further investigation into the pathophysiology of Tourette syndrome is essential to pave the way for novel interventions targeting neural noise levels and patterns directly in Tourette syndrome.
NEUROIMAGE-CLINICAL
(2021)
Article
Biochemistry & Molecular Biology
Theresa Paulus, Lynn Wernecke, Annik Lundie, Julia Friedrich, Julius Verrel, Tina Rawish, Anne Weissbach, Christian Frings, Christian Beste, Tobias Baeumer, Alexander Muenchau
Summary: Research shows that inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to the left BA40 is not effective in alleviating tic symptoms in GTS patients. The left BA40 does not appear to be a useful target for modulating tic symptoms in GTS.
Article
Multidisciplinary Sciences
Akane Yoshikawa, Itaru Kushima, Mitsuhiro Miyashita, Kazuhiro Suzuki, Kyoka Iino, Kazuya Toriumi, Yasue Horiuchi, Hideya Kawaji, Norio Ozaki, Masanari Itokawa, Makoto Arai
Summary: A subtype of schizophrenia, PEN-SCZ, may be associated with a novel deletion in the IMMP2L gene, leading to glycation/oxidative stress in neuronal cells and potentially linked with autism spectrum disorder. The combination of genomic information with plasma pentosidine levels contributes to the classification of biological SCZ subtypes.
Article
Medicine, General & Internal
Piotr Janik, Anna Dunalska, Natalia Szejko, Andrzej Jakubczyk
Summary: Coprolalia and echophenomena repetition known as CTPh are rare in Gilles de la Tourette syndrome (GTS) patients, with a higher occurrence in adolescence and adulthood. As patients age, the severity of tics increases and anxiety disorder is significantly associated with CTPh, indicating that they may be part of the tic spectrum and are age-related symptoms of GTS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Ryunosuke Goto, Natsumi Matsuda, Maiko Nonaka, Yu Hamamoto, Yosuke Eriguchi, Mayu Fujiwara, Akane Suzuki, Yukari Yokoyama, Yukiko Kano
Summary: This study provides evidence on the validity and reliability of the GTS-QOL scale in Japanese patients with GTS, making it an effective tool for measuring disease-specific HR-QOL in this population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Petra Heiden, Mauritius Hoevels, Dilruba Bayram, Juan C. Baldermann, Thomas Schueller, Daniel Huys, Veerle Visser-Vandewalle, Pablo Andrade
Summary: This study analyzed the connectivity profiles of different DBS targets for GTS and found significant differences in the connectivity profiles of standard targets. The pvGPi showed the strongest connection to the sensorimotor cortex, while the amGPi showed the strongest connection to the prefrontal cortex. Using probabilistic tractography based on patient data and a normative connectome revealed differences in connectivity profiles.
Review
Genetics & Heredity
Amanda M. Levy, Peristera Paschou, Zeynep Tumer
Summary: GTS is a childhood-onset neurodevelopmental and psychiatric disorder that is often comorbid with OCD and ADHD. Genetic factors play a significant role in disease etiology, but identifying major susceptibility genes has been challenging due to the complex interplay between multiple genetic factors and environmental influences.
Article
Chemistry, Multidisciplinary
Xueqin He, Jiang Xie, Jing Zhang, Xiaorong Wang, Xufeng Jia, Heng Yin, Zhongqing Qiu, Zhihang Yang, Jiao Chen, Zhiliang Ji, Wenqi Yu, Meiwan Chen, Wenming Xu, Huile Gao
Summary: This study established an aspirin encapsulated cascade drug delivery system (Asp@TMNPs) that targets the blood-brain barrier and microglial cells, effectively alleviating mitochondrial oxidative stress, DNA damage, and inflammation in microglial cells. After treatment with Asp@TMNPs, social interaction, stereotype behavior, and anxious condition in ASD mice were notably improved, and microglial cell activation was inhibited.
Article
Biology
Diana Weiting Tan, Syed Zulqarnain Gilani, Gail A. Alvares, Ajmal Mian, Andrew J. O. Whitehouse, Murray T. Maybery
Summary: The broad autism phenotype refers to sub-clinical levels of autistic-like behavior and cognition in biological relatives of autistic people. A recent study found that increased facial masculinity may also be a feature of the broad autism phenotype. This study further investigated the presence of increased facial masculinity among non-autistic parents of autistic children and found that they had significantly higher masculinity scores and larger facial distances compared to a comparison group.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: Tonic tics (TTs) are common in patients with Gilles de la Tourette syndrome (GTS), with a prevalence of 85.2% in adults and 63.9% in children and adolescents. TTs are associated with a greater number of tics, more severe symptoms, and more comorbidities in both age groups.
Article
Genetics & Heredity
Mathis Hildonen, Amanda M. Levy, Christina Dahl, Victoria A. Bjerregaard, Lisbeth Birk Moller, Per Guldberg, Nanette M. Debes, Zeynep Tumer
Summary: This study found that SLC6A4 expression is upregulated in individuals with Gilles de la Tourette syndrome compared to healthy controls. The L-AC/L-AC genotype of the 5-HTTLPR/rs25531/rs25532 three-locus haplotype was associated with higher SLC6A4 mRNA expression levels in GTS individuals.
Article
Clinical Neurology
Saar Anis, Corinne Zalomek, Amos D. Korczyn, Alina Rosenberg, Nir Giladi, Tanya Gurevich
Summary: This study assessed the effectiveness and tolerability of medical cannabis in adult patients with Gilles de la Tourette syndrome. The results showed that medical cannabis treatment significantly reduced the severity of symptoms and was well tolerated. However, smoking was the most common mode of administration, and further research is needed to compare the efficacy of different modes. Additionally, cognitive and psychiatric side effects need to be monitored and addressed during treatment.
BEHAVIOURAL NEUROLOGY
(2022)
Article
Medicine, General & Internal
Valsamma Eapen, Siaw-Teng Liaw, Raghu Lingam, Susan Woolfenden, Bin Jalaludin, Andrew Page, Jane Kohlhoff, James G. Scott, K. D. Lawson, Christa Lam-Cassettari, Helen Heussler, Joseph Descallar, Lisa Karlov, Natalie Ong, Paul B. Colditz, Robyn Littlewood, Elisabeth Murphy, April Deering, Kate Short, Pankaj Garg, Victoria Blight, Kim Rodgers, Lucille Chalmers, Kerri-Lyn Webb, Heidi Atkins, Dana Newcomb, Rachael Beswick, Clare Thomas, Catherine Marron, Aaron Chambers, Sue Scheinpflug, Matt Statham, Dimuthu Samaranayake, Paul Chay, Chun Wah Michael Tam, Feroza Khan, Antonio Mendoza Diaz, Sara Cibralic, Teresa Winata, Margo Pritchard
Summary: This study aims to evaluate an innovative web-based developmental surveillance program and a sustainable approach to referral and care pathways, addressing the variation in developmental surveillance and low rates of developmental screening uptake in different regions of Australia.
Letter
Psychiatry
James John, Ei Phyu Synn, Teresa Winata, Valsamma Eapen, Ping- Lin
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Psychology, Developmental
David Trembath, Kandice Varcin, Hannah Waddington, Rhylee Sulek, Cathy Bent, Jill Ashburner, Valsamma Eapen, Emma Goodall, Kristelle Hudry, Jacqueline Roberts, Natalie Silove, Andrew Whitehouse
Summary: This article reports the findings of an umbrella review of 58 systematic reviews of non-pharmacological interventions for autistic children. The results show that some interventions have positive therapeutic effects, but no single intervention has a positive effect on all child and family outcomes. The influence of child and delivery characteristics on the effects is unclear. These findings provide evidence-based decision-making guidance for parents, practitioners, and policymakers in selecting interventions and highlight the importance of individualized approaches in the absence of clear and consistent evidence.
Article
Psychiatry
Valsamma Eapen, Anthea Stylianakis, Elizabeth Scott, Helen Milroy, Michael Bowden, Ric Haslam, Stephen Stathis
Summary: One in five people experience mental health problems before the age of 25, and one in seven children in Australia have a mental health disorder. However, many children and young people with mental health difficulties are not accessing appropriate care, partly due to the fragmented nature of child mental health services. To address this issue, a novel Integrated Continuum of Connect and Care model is proposed to provide timely and tailored mental health services for children and young people.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Antonio Mendoza Diaz, Ron Brooker, Sara Cibralic, Elisabeth Murphy, Sue Woolfenden, Valsamma Eapen
Summary: The purpose of this perspective article is to emphasize the importance of the 'First 2000 Days' policy and propose new directions for its implementation. It highlights principles of responsiveness, integration, sustainability, and equity, and suggests innovations in data collection and linkages. The article proposes a framework for improving health systems' implementation of services in the first 5 years of life through a coordinated continuum of services with integrated physical and digital solutions.
AUSTRALIAN HEALTH REVIEW
(2023)
Article
Green & Sustainable Science & Technology
Sima Alizadeh, Catherine. E. E. Bridge, Bruce. H. H. Judd, Valsamma Eapen
Summary: This study investigated the impact of housing indoor environmental quality (IEQ) on the symptoms and severity of attention deficit hyperactivity disorder (ADHD) among children and adolescents. The results showed that all IEQ factors were associated with the diagnosis and severity of ADHD symptoms. Improving thermal comfort, air quality, and lighting quality in housing design could positively correlate with alleviating ADHD symptoms and severity.
Review
Psychiatry
Tamara May, Edwina Birch, Karina Chaves, Noel Cranswick, Evelyn Culnane, Jane Delaney, Maddi Derrick, Valsamma Eapen, Chantele Edlington, Daryl Efron, Tatjana Ewais, Ingrid Garner, Michael Gathercole, Karuppiah Jagadheesan, Laura Jobson, John Kramer, Martha Mack, Marie Misso, Cammi Murrup-Stewart, Evan Savage, Emma Sciberras, Bruce Singh, Renee Testa, Lisa Vale, Alyssa Weirman, Edward Petch, Katrina Williams, Mark Bellgrove
Summary: This article provides an overview of the development and recommendations from the Australian evidence-based clinical practice guideline for ADHD. The guideline aims to promote accurate diagnosis and optimal treatment, integrating evidence, clinical expertise, and patient preferences. It includes 113 clinical recommendations for children, adolescents, and adults, covering identification, screening, diagnosis, and treatment options. Successful implementation of the guideline is anticipated to improve health outcomes for the ADHD population in Australia.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Clinical Neurology
Katarina Ostojic, Isra P. Karem, Simon P. Paget, Alison Berg, Betty-Jean Dee-Price, Raghu C. Lingam, Russell C. Dale, Valsamma Eapen, Sue Woolfenden
Summary: Social determinants of health (SDH) have both positive and negative impacts on health and social outcomes. Understanding how SDH affects children with cerebral palsy (CP) is crucial for improving health equity, optimizing health outcomes, and supporting their families. This review examines the impact of SDH on CP children globally. In high-income countries, socioeconomic disadvantage is associated with more severe comorbidities, spastic bilateral CP, and reduced community participation. In low- and middle-income countries, socioeconomic disadvantage is linked to malnutrition, poor housing conditions, lack of sanitation, and poverty.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Neurosciences
Rose Chesworth, Gabriela Visini, Tim Karl
Summary: The study investigates if genetic risk for schizophrenia affects drug reward and reinforcement for cocaine. The results suggest that Nrg1 mutation impairs response inhibition for cocaine and limits control over its use.
PSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Jane Kohlhoff, Sophia A. Harris, Kenny D. Lawson, Valsamma Eapen
Summary: The paper presents the evaluation protocol of the ForWhen program in Australia, which aims to improve outcomes for families by supporting them to access perinatal and infant mental health services. The evaluation will examine the characteristics of service delivery, implementation, clinical impact, and potential moderators of change. It will use a mixed-methods design and incorporate quantitative and qualitative data.
Article
Health Care Sciences & Services
Pravin Dullur, Joanne Joseph, Antonio Mendoza Diaz, Ping- Lin, Rajeev Jairam, Rhian Davies, Anne Masi, Boaz Shulruf, Valsamma Eapen
Summary: This study aims to identify patterns of internet use in young people with mental health concerns in the emergency department (ED) using a new measure called the emergency department media use screener (EDMUS). The study found that sharing suicidal digital content was the most common problematic internet use pattern, but it did not correlate with prior mental health diagnosis or predict readmission. Diagnoses of personality disorder or posttraumatic stress disorder were independent predictors of readmission.
JMIR FORMATIVE RESEARCH
(2023)
Article
Behavioral Sciences
Georgia Watt, Tim Karl, Rose Chesworth
Summary: Circadian rhythm has significant impacts on the physiological domains and behavior expression in mice, such as body temperature, hormone levels, and immune function. However, the effects on cognitive behavior are not well-established, and there is limited research on the impact of circadian rhythm on operant responding in mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychology, Clinical
Saskia Drever, Rachael Foord, Antonio Mendoza Diaz, Valsa Eapen, Rajeev Jairam
Summary: A tiered model of mental health care has been implemented in Sydney to address the complex mental health needs of young people in out-of-home care (OOHC). The results of the study show that OOHC-MHT provided more intense services for those with severe mental health needs, as indicated by worse HoNOSCA scores. However, both the OOHC-MHT and iCAMHS groups showed significant improvements in psychopathology, with the tiered model of care resulting in improved outcomes.
CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Clinical
Silvana Kaouar, Georgette E. Fleming, Bryan Neo, David J. Hawes, Valsamma Eapen, Eva R. Kimonis
Summary: The study explores the developmental psychopathology of child conduct problems by differentiating subtypes based on levels of internalizing problems and/or callous-unemotional traits. The findings suggest that mothers of children with high levels of internalizing problems and high callous-unemotional traits have fewer warm attributions and more negative dyadic relationships compared to mothers of children with high callous-unemotional traits but low levels of internalizing problems. Mothers of children with high callous-unemotional traits and low levels of internalizing problems attribute fewer good and altruistic intentions towards others in their child.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2023)
Article
Health Care Sciences & Services
Valsamma Eapen, Brigitte Gerstl, Teresa Winata, Rajeev Jairam, Giles Barton, Michael Bowden
Summary: This paper discusses the urgency of developing and evaluating innovative solutions to address the increasing number of children and young people presenting with acute mental health crises. Through the evaluation of the Safeguards Teams Program (STP), the aim is to provide early access to evidence-based specialist care for children and young people in acute mental health crises and their families/caregivers.
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)