期刊
ATHEROSCLEROSIS
卷 290, 期 -, 页码 1-8出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2019.09.005
关键词
Familial hypercholesterolaemia; Heterozygous familial hypercholesterolaemia; Children and young people; Statin treatment; Lifestyle advice
资金
- British Heart Foundation (BHF)
- HEART UK
- Royal College of Physicians
- International Atherosclerosis Society [Pfizer 24052829]
- BHF [PG08/008]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- MRC [G1002158] Funding Source: UKRI
This consensus statement on the management of children and young people with heterozygous familial hypercholesterolaemia (FH) addresses management of paediatric FH in the UK, identified by cascade testing when a parent is diagnosed with FH and for those diagnosed following incidental lipid tests. Lifestyle and dietary advice appropriate for children with FH; suggested low density lipoprotein cholesterol (LDL-C) targets and the most appropriate lipid-lowering therapies to achieve these are discussed in this statement of care. Based on the population prevalence of FH as similar to 1/250 and the UK paediatric population, there are approximately 50,000 FH children under 18 years. Currently only about 550 of these children and young people have been identified and are under paediatric care.
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