Article
Endocrinology & Metabolism
Xiayi Wu, Yi Li, Zeyuan Cao, Yunyi Xie, Chuanqiang Fu, Huan Chen
Summary: The study found that cyclic tensile stress can enhance the osteogenic differentiation ability of human periodontal ligament stem cells (hPDLSCs) by regulating the expression levels of miR-129-5p and BMP2, and activating the BMP2/Smad signaling pathway. This stimulative effect is manifested by increased ALP activity, osteogenesis-related gene expression, mineralized nodules, and positive ALP staining.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Changyun Sun, Mila Janjic Rankovic, Matthias Folwaczny, Thomas Stocker, Sven Otto, Andrea Wichelhaus, Uwe Baumert
Summary: This study investigated the effects of different magnitudes and durations of static tensile strain on human periodontal ligament cells. The results showed that lower magnitudes of strain promoted osteogenesis and caused less inflammation, while higher magnitudes inhibited osteogenesis and enhanced inflammation. Among all magnitudes, 10% generally caused a lower level of inflammation with a higher level of osteogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Wenfang Wang, Meijuan Wang, Xiaomei Guo, Yunshan Zhao, Madiha Mohammed Saleh Ahmed, Hong Qi, Xi Chen
Summary: The osteoblastic differentiation of periodontal ligament stem cells (PDLSCs) under mechanical tensile force is frequency-dependent. EYA1 and SALL1 were identified as potential important tensile frequency-sensitive genes, which may contribute to the cyclic tension-induced osteogenic differentiation of PDLSCs in a frequency-dependent manner.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Minjie Li, Zhongyuan Tang, Chengfei Zhang, Lijian Jin, Koichi Matsuo, Yanqi Yang
Summary: Simultaneous stimulation by LPS and CF significantly suppresses EphB4 expression and enhances ephrinA2 expression. This stimulation also intensifies osteoclastic differentiation, while sequential exposure to LPS and CF only slightly increases osteoclastic cell numbers.
Article
Pharmacology & Pharmacy
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Takashi Matsuo
Summary: The study found that nobiletin effectively inhibited inflammatory responses in IL-1 beta-stimulated HPDLCs by reducing the expression of inflammatory cytokines, cell adhesion molecules, and MMPs. Additionally, nobiletin treatment also suppressed the activation of NF-kappa B, MAPKs, and Akt pathways.
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Dentistry, Oral Surgery & Medicine
Xiaocen Zhang, Maolin Chang, Beike Wang, Xiaoyu Liu, Zhen Zhang, Guangli Han
Summary: This study verified the role of the YAP/WNT5A/FZD4 axis in the stretch-induced osteogenic differentiation of hPDLCs. It was found that YAP positively regulated the expression of WNT5A and FZD4, and their axis mediated the osteogenic differentiation of hPDLCs under cyclic stretch. Knockdown of WNT5A and FZD4 attenuated YAP-induced and stretch-induced osteogenic differentiation. In conclusion, the YAP/WNT5A/FZD4 axis plays an important role in the biological mechanism of orthodontic tooth movement.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Engineering, Biomedical
Bin Wu, Ke Cheng, Mao Liu, Jingjing Liu, Di Jiang, Songyun Ma, Bin Yan, Yi Lu
Summary: In this study, the effect of spatial distribution of collagen fibers on the mechanical properties of human PDL was quantitatively described. The accuracy of the model was verified by uniaxial test data, and the relevant model parameters were obtained, which have certain reference value in subsequent research on hyperelasticity of human PDL and clinical treatment.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Changyun Sun, Mila Janjic Rankovic, Matthias Folwaczny, Sven Otto, Andrea Wichelhaus, Uwe Baumert
Summary: This systematic review summarizes the role of hPDLCs in mechanosensing and mechanotransduction during orthodontic tooth movement, as well as the effects of tension application on genes, proteins, and metabolites, along with the identification of signaling pathways involved. It provides important insights for future research in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yongxi Liang, Ajay Shakya, Xiaohua Liu
Summary: This study designed and fabricated a bioinspired tubular 3D matrix to guide the migration and growth of human periodontal ligament stem cells (PDLSCs) and form aligned fiber bundles. The tubular matrix controlled cell migration and alignment through inhibiting osteogenic differentiation. Mechanism study revealed involvement of the Yap1/Twist1 signaling pathway.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhongqi Zhao, Christian Behm, Marco Aoqi Rausch, Zhiwei Tian, Xiaohui Rausch-Fan, Oleh Andrukhov
Summary: The study investigates the combined effect of mechanical stress and TNF-alpha on inflammatory response in human periodontal ligament stromal cells. It was found that mechanical force can differentially regulate the expression of inflammatory mediators and adhesion molecules induced by TNF-alpha, with potential anti-inflammatory or pro-inflammatory effects depending on the type of mediators and force magnitude.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Byul-Bora Choi, Jeong-Hae Choi, Tae-Hyung Kang, Seok-Jun Lee, Gyoo-Cheon Kim
Summary: Periodontitis is an inflammatory disease that leads to periodontal tissue destruction and bone resorption. This study found that nozone cold plasma treatment can promote osteoblastic differentiation of periodontal ligament cells, potentially offering benefits for treating periodontitis.
Article
Genetics & Heredity
Lingli Xu, Chengze Wang, Yongzheng Li, Ying Wang, Baiping Fu, Guoli Yang
Summary: This study elucidated the molecular mechanism of mechanical force regulating the osteogenic differentiation of periodontal ligament stem cells (PDLSCs), and identified the key role of ANGPTL4 in this process. The findings suggest a positive relationship between ANGPTL4 and osteogenic differentiation of PDLSCs.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Multidisciplinary Sciences
Torkan Gholamalizadeh, Sune Darkner, Peter Lempel Sondergaard, Kenny Erleben
Summary: This study investigates the force systems used for tooth position correction in orthodontic treatments by studying different types of tooth movements and the effect of couple force direction on the position of the center of rotation (CRot). Results show that similar patterns can be obtained for CRot positions of different patients and teeth under the same load conditions, but changes in force and couple directions can cause misalignment of CRot trajectories.
Article
Dentistry, Oral Surgery & Medicine
Jeeranan Manokawinchoke, Suconta Chareonvit, Vorapat Trachoo, Phoonsuk Limraksasin, Hiroshi Egusa, Thanaphum Osathanon
Summary: This study investigated the effect of intermittent compressive force (ICF) on the expression of dentin matrix protein-1 (DMP1) in human periodontal ligament stem cells (hPDLSCs). It was found that ICF could induce DMP1 expression through the regulation of the TGF-b signaling pathway.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Nattapol Boonmak, Jitti Niyompanich, Piyachat Chuysinuan, Pimolpun Niamlang, Pongpol Ekabutr, Pitt Supaphol
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Cell Biology
Yanee Tantilertanant, Jitti Niyompanich, Vincent Everts, Pitt Supaphol, Prasit Pavasant, Neeracha Sanchavanakit
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Polymer Science
Sonthaya Chaiarwut, Jitti Niyompanich, Pongpol Ekabutr, Piyachat Chuysinuan, Prasit Pavasant, Pitt Supaphol
Summary: Hydroxyapatite (HAp) has potential for various biomedical applications, and enhancing its antimicrobial properties could prevent bacterial persistence in chronic infections. Xanthone substance from mangosteen extract effectively inhibited bacterial growth on HAp granules and showed positive results in cytotoxicity studies, suggesting potential for bone tissue engineering applications.
Article
Polymer Science
Jitti Niyompanich, Piyachat Chuysinuan, Prasit Pavasant, Pitt Supaphol
Summary: Poloxamer hydrogels are thermoresponsive hydrogels that can transition between fluid and gel states. By adjusting the composition, the gelation temperature can be tailored for various applications. The hydrogels exhibited good biocompatibility, drug release capabilities, and antibacterial properties when loaded with gentamicin sulfate.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Polymer Science
Jitti Niyompanich, Piyachat Chuysinuan, Prasit Pavasant, Pitt Supaphol
Summary: Poly(epsilon-caprolactone) (PCL) scaffolds with interconnecting pore were surface modified using layer-by-layer (LbL) deposition of poly(diallyldimethylammonium chloride) (PDADMAC) and poly(sodium 4-styrenesulfonate) (PSS) to immobilize osteopontin (OPN) and enhance osteogenic differentiation of MC3T3-E1 cells, as demonstrated by in vitro biological evaluation.
Article
Engineering, Environmental
Sonthaya Chaiarwut, Chasuda Choipang, Pakakrong Sangsanoh, Jitti Niyompanich, Pitt Supaphol
Summary: This study focuses on the development of polyurethane foams with antibacterial and anti-inflammatory activities using natural extracts to alleviate pain during wound treatment. The results showed that the Anti-inflame #3 foam, containing a ratio of mangosteen to curcumin extract of 1:2, exhibited the best antibacterial and antioxidant effects, making it a promising antimicrobial wound dressing material.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Kunyawan Thaungwilai, Yanee Tantilertanant, Weerachai Singhatanadgit, Pairod Singhatanadgid
Summary: The biomechanics of non-restorable crownless primary molars restored by stainless steel crowns (SSC) using different composite core build-up materials were investigated. It was found that the type of core build-up material influenced the stress distribution and safety factor of the restored molars. The nano-filled resin-modified glass-ionomer cement (NRMGIC) showed the best performance overall, with low stress and high safety factor.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Paphawee Somrit, Yanee Tantilertanant, Sirivimol Srisawasdi
Summary: This study aimed to evaluate the effect of application techniques, type of adhesives, and remaining dentin thicknesses on micro-tensile bond strength of 3 adhesive systems. The results showed that remaining dentin thickness and application technique significantly affected the bond strength, and different adhesive systems had different effects on the bond strength to dentin.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)