Article
Medicine, Research & Experimental
Soudabeh Balarastaghi, Samira Barangi, Hossein Hosseinzadeh, Mohsen Imenshahidi, Zahra Moosavi, Bibi Marjan Razavi, Gholamreza Karimi
Summary: Arsenic is a heavy metal that can cause vascular toxicity. Melatonin, a hormone, has been shown to have protective effects against oxidative stress and apoptosis, as well as modulating autophagy. This study found that melatonin can protect against arsenic-induced vascular toxicity by inhibiting apoptosis and regulating the Sirt1/autophagy pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Gan Rao, Gaolong Zhong, Ting Hu, Shaofeng Wu, Jiajia Tan, Xiaoyong Zhang, Riming Huang, Zhaoxin Tang, Lianmei Hu
Summary: In this study, ducks were used to mimic arsenic trioxide (ATO) exposure and investigate its mechanism of cardiac toxicity. The results showed that ATO inhibited body and organ growth, increased LDH levels, and caused deformity and ischemia infarction in ducks. Transmission electron microscopy revealed that ATO exacerbated mitochondrial swelling and cell nuclei contraction in the duck heart. ATO also induced oxidative stress and apoptosis, via the Nrf 2/Caspase 3 signaling pathway, by altering the expression levels of various genes and proteins related to apoptosis and oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chandra Prakash, Sunil Chhikara, Vijay Kumar
Summary: Mitochondria, as essential cellular organelles associated with energy production and signaling pathways, are targeted by environmental pollutants such as arsenic. Arsenic, a toxic metalloid contaminant of drinking water, is particularly toxic to cellular organs like the liver, primarily affecting mitochondrial function and integrity. Research suggests that arsenic induces oxidative stress and alters signaling pathways within cells, emphasizing the importance of understanding mechanistic aspects of mitochondrial dysfunction in arsenic-induced hepatotoxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Moamen Adel Mashaly, Ibrahim Ghalib Saleh, Ahmed Amine Ashour, Ahmed Mohamed Mansour
Summary: This study evaluates the safety of quercetin and investigates its effects in normal and lipopolysaccharide-primed livers. It also examines the influence of mild inflammation/fever on quercetin effects.
Article
Biochemistry & Molecular Biology
Mohammed A. El-Magd, Amina M. G. Zedan, Nahla S. Zidan, Mohamed Sakran, Omar Bahattab, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Adel Alalawy, Amira M. Elmoslemany
Summary: Avocado seeds (AvS) were found to attenuate cyclosporine A (CsA)-induced hepatotoxicity in rats by inhibiting oxidative stress and proapoptotic endoplasmic reticulum (ER) stress.
Article
Multidisciplinary Sciences
Pallab Kar, Swarnendra Banerjee, Md. Moshfekus Saleh-E-In, Akash Anandraj, Emil Kormuth, Suntheren Pillay, Abdullah Ahmed Al-Ghamdi, Mohammad Ajmal Ali, Joongku Lee, Arnab Sen, Devashan Naidoo, Ayan Roy, Yong Eui Choi
Summary: This study found that beta-sitosterol conjugated silver nanoparticles (BSAgNPs) could ameliorate carbon tetrachloride (CCl4)-induced liver injury. BSAgNPs may activate the Nrf(2) gene through potential inhibition of TGF-β1/Smad signaling and exert an antifibrotic effect, reducing chronic inflammation, oxidative stress, and collagen deposition.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Huma Khan, Yeshvandra Verma, S. V. S. Rana
Summary: Combined exposure to arsenic and fluoride can lead to hepatocellular death through mechanisms involving inflammation and apoptosis regulation, possibly triggered by increased generation of nitric oxide and activation of caspase proteins. The study suggests that the co-exposure results in greater cellular damage than when exposed individually to either arsenic or fluoride.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Medicine, Research & Experimental
Seyyedeh Mina Hejazian, Seyed Mahdi Hosseiniyan Khatibi, Abolfazl Barzegari, Graciela Pavon-Djavid, Saiedeh Razi Soofiyani, Sina Hassannejhad, Elham Ahmadian, Mohammadreza Ardalan, Sepideh Zununi Vahed
Summary: Nrf-2 plays a crucial protective role in the kidneys, helping to alleviate acute kidney injury triggered by inflammation and oxidative stress. Understanding the molecular mechanisms of AKI is essential for balancing renal adaptation and dysfunction, reducing disease progression.
Article
Biochemistry & Molecular Biology
Urmi Mukherjee, Anwesha Samanta, Subhasri Biswas, Soumyajyoti Ghosh, Sambuddha Banerjee, Sudipta Maitra
Summary: The study investigates the impact of Nonylphenol (NP) on liver health and finds that NP exposure can lead to chronic liver injury through oxidative stress, metabolic disruption, and immune modulation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Tauseef Alam, Sana Rizwan, Zeba Farooqui, Subuhi Abidi, Iqbal Parwez, Farah Khan
Summary: Arsenic is a potent hepatotoxin, while studies have shown that Nigella sativa oil has a protective effect on acute liver injury and can improve liver function. Experimental findings suggest that Nigella sativa oil can alleviate liver damage caused by arsenic, and improve the antioxidant and metabolic status of the liver.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Alberto J. Nunez-Selles, Lauro Nuevas-Paz, Gregorio Martinez-Sanchez
Summary: This study found that metal-mangiferin complexes have good antioxidant and protection against protein oxidative damage effects in the adjuvant therapies of neurodegenerative diseases, cancer, diabetes, and cardiovascular disorders. The coordination complexes of Se (IV) and Zn (II) with mangiferin showed significantly improved antioxidant/protective effects compared to isolated mangiferin.
APPLIED SCIENCES-BASEL
(2022)
Review
Environmental Sciences
Wenxi Song, Youshuang Wang, Tingyu Huang, Yu Liu, Fengjuan Chen, Yunhe Chen, Yibao Jiang, Cong Zhang, Xu Yang
Summary: T-2 toxin, a type A trichothecene produced by various Fusarium species, is highly toxic and causes severe damage to the liver and other organs. Its contamination is widespread in plants globally, posing a great threat to human and animal health due to its chemical stability and difficulty to remove completely from food and feed. This review summarizes the recent research on the hepatotoxicity of T-2 toxin and discusses its metabolic characteristics, hepatotoxic mechanisms, and potential detoxification strategies.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, Research & Experimental
Huda M. Ismail Abo El-Fadl, Mamdouh F. A. Mohamed
Summary: The study aimed to investigate the role of myristicin in modulating endoplasmic reticulum stress (ERS) and risk-associated conditions in acetic acid (AA)-induced UC in rats. Results suggest that myristicin effectively reverses the deteriorated effects of ulceration by downregulating ERS markers, reducing DNA fragmentation, lipid peroxidation, and inflammatory markers.
Article
Biochemistry & Molecular Biology
Mingzhu Yan, Zhi Wang, Tianji Xia, Suwei Jin, Yongguang Liu, Hongbo Hu, Qi Chang
Summary: This study investigated the role of ER-phagy in APA-induced liver injury (AILI) and found that delayed treatment with glycyrrhizin (GCM) can promote liver recovery by enhancing ER-phagy.
Article
Medicine, Research & Experimental
Zunaira Syed, Bushra Shal, Aqsa Azhar, Safa Amanat, Adnan Khan, Hussain Ali, Yun-Seo Kil, Eun Kyoung Seo, Salman Khan
Summary: The present study investigated the effect of xanthoangelol on Alzheimer's disease (AD). Xanthoangelol showed neuroprotective effects and reduced the symptoms of AD by improving signaling pathways, activating antioxidants, attenuating apoptotic pathways, and reducing neuroinflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Sushweta Mahalanobish, Sukanya Saha, Sayanta Dutta, Parames C. Sil
PHARMACOLOGICAL RESEARCH
(2020)
Article
Food Science & Technology
Sushweta Mahalanobish, Sayanta Dutta, Sukanya Saha, Parames C. Sil
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Oncology
Masahiro Shibata, Akira Ooki, Yoshikuni Inokawa, Pritam Sadhukhan, M. Talha Ugurlu, Evgeny Izumchenko, Enrico Munari, Giuseppe Bogina, Charles M. Rudin, Edward Gabrielson, Anju Singh, Mohammad O. Hoque
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Masamichi Hayashi, Elisa Guida, Yoshikuni Inokawa, Rachel Goldberg, Leonardo O. Reis, Akira Ooki, Manohar Pilli, Pritam Sadhukhan, Juhyung Woo, Woonyoung Choi, Evgeny Izumchenko, Leonel Maldonado Gonzalez, Luigi Marchionni, Alex Zhavoronkov, Mariana Brait, Trinity Bivalacqua, Alexander Baras, George J. Netto, Wayne Koch, Anju Singh, Mohammad O. Hoque
Article
Materials Science, Biomaterials
Mousumi Kundu, Pritam Sadhukhan, Noyel Ghosh, Sumit Ghosh, Sharmistha Chatterjee, Joydeep Das, Goutam Brahmachari, Parames C. Sil
Summary: The study evaluated the in vivo therapeutic efficacy and systemic toxicity profile of a synthetic anticancer compound, showing that a controlled drug delivery system using PBA functionalized and GN gated MSN can enhance the therapeutic potential of the compound without causing significant systemic toxicity.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Oncology
Sarah E. Mudra, Pritam Sadhukhan, M. Talha Ugurlu, Shorna Alam, Mohammad O. Hoque
Summary: Resistance to cancer therapy is a significant obstacle, with cancer stem cells (CSCs) playing a key role in resistance and the need for novel targeted agents to combat CSCs.
Article
Nanoscience & Nanotechnology
Sanjib Sarkar, Pritam Sadhukhan, Dibyendu Das, Purashri Basyach, Joydeep Das, Manash R. Das, Lakshi Saikia, Sawlang Borsingh Wann, Jatin Kalita, Parames C. Sil, Prasenjit Manna
Summary: This study investigated the glucose-responsive delivery of vitamin K using dextran-capped mesoporous silica nanoparticles (MSNs) functionalized with 3-carboxyphenylboronic acid (CPBA). The results showed that the system not only delivered VK in a glucose-dependent manner but also significantly improved its bioavailability.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Sushweta Mahalanobish, Sukanya Saha, Sayanta Dutta, Sumit Ghosh, Parames C. Sil
Summary: The study demonstrates the efficacy of melatonin in controlling the renin-angiotensin system (RAS) in the context of chronic lung injury induced by cadmium (Cd) exposure. Melatonin treatment effectively inhibits inflammatory responses and necroptotic cell death mediated by Angiotensin-II (Ang-II), thereby protecting the alveolar-capillary barrier from Cd toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Neeraj Tejwan, Pritam Sadhukhan, Anirudh Sharma, Th. Abhishek Singh, Madushmita Hatimuria, Ashok Pabbathi, Joydeep Das, Parames C. Sil
Summary: In this study, carbon dots (CDs) were synthesized from red Korean ginseng and further modified with folic acid (FA) to deliver rutin (RUT) for targeted cancer therapy. The resulting FA conjugated and rutin loaded CDs (FA-CDs-RUT) exhibited size of approximately 70 nm, drug loading content of 14.5%, and a pH-dependent drug release behavior. The nanohybrid demonstrated dose-dependent cytotoxicity and anti-migratory effect in human breast cancer MCF-7 cells. In vivo administration of FA-CDs-RUT was found to effectively inhibit tumor growth in mice without causing significant alterations in blood biochemical parameters. Molecular docking study revealed the potential interaction between rutin and Bcl-2, suggesting a possible mechanism of action. Overall, this study highlights the potential of FA-CDs-RUT for breast cancer treatment.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Neelam Thakur, Pritam Sadhukhan, Mousumi Kundu, Th. Abhishek Singh, Madushmita Hatimuria, Ashok Pabbathi, Joydeep Das, Parames C. Sil
Summary: In this study, folic acid-conjugated and amine-functionalized cerium oxide nanoparticles (CeO2-NH-FA) were synthesized for targeted and controlled delivery of Morin to breast cancer cells overexpressing folic acid. The resulting nanohybrids exhibited significant cytotoxicity against breast cancer cells and a potential antimigratory effect. In addition, the nanohybrids showed improved anticancer efficacy compared to free Morin and CeO2-NH-FA in tumor-bearing mice. The study highlights the potential of the Morin-CeO2-NH-FA nanohybrids as a drug delivery vehicle for cancer treatment.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Immunology
Pritam Sadhukhan, Tanguy Y. Seiwert
Summary: The complexity and plasticity of the tumor microenvironment make it challenging to comprehend the intratumoral regulation of different cell types and their activities. Tumor-associated macrophages (TAMs), a subtype of macrophages, have a significant impact on the signaling dynamics of the tumor microenvironment. TAMs play a crucial role in regulating cancer cell activities, immunosuppression, and resistance to chemotherapy and immunotherapy. This review focuses on the mechanisms by which TAMs modulate immune signaling in the tumor microenvironment and recent preclinical research on developing therapeutics targeting TAMs and tumor metabolism.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Article
Cell Biology
Sayanta Dutta, Sushweta Mahalanobish, Sukanya Saha, Mullicka Mandal, Sanchari Begam, Pritam Sadhukhan, Sumit Ghosh, Goutam Brahmachari, Parames C. Sil
Summary: Selective initiation of programmed cell death in cancer cells was achieved by a synthetic bis-coumarin derivative 3 l, which demonstrated promising cytotoxic ability and apoptosis induction specifically in human renal carcinoma cells (SKRC-45). This compound modulated apoptotic pathways and inhibited NF-kappa B nuclear localization, resulting in reduced proliferation, survival, and migration ability of SKRC-45 cells. In an in vivo tumor model, 3 l exhibited an anticancer effect without affecting kidney function.
CELLULAR SIGNALLING
(2023)
Editorial Material
Pharmacology & Pharmacy
Sukanya Saha, Shatadal Ghosh
FRONTIERS IN PHARMACOLOGY
(2023)
Meeting Abstract
Oncology
Pritam Sadhukhan, Mingxiao Feng, Emily Illingworth, Ido Sloma, M. Talha Ugurlu, Fenna Sille, Woonyoung Choi, David J. McConkey, Mohammad Hoque
MOLECULAR CANCER THERAPEUTICS
(2021)
Meeting Abstract
Oncology
M. Talha Ugurlu, Rachel Goldberg, Pritam Sadhukhan, Mohammad O. Hoque
MOLECULAR CANCER THERAPEUTICS
(2021)