期刊
BIOESSAYS
卷 38, 期 5, 页码 482-489出版社
WILEY-BLACKWELL
DOI: 10.1002/bies.201500198
关键词
genome-wide map; genomic imprinting; Grb10; Igf2; intragenomic conflict; kinship theory; RNA-seq
资金
- Office of Integrative Activities
- Office Of The Director [1355438] Funding Source: National Science Foundation
Three recent genome-wide studies in mice and humans have produced the most definitive map to date of genomic imprinting (gene expression that depends on parental origin) by incorporating multiple tissue types and developmental stages. Here, we explore the results of these studies in light of the kinship theory of genomic imprinting, which predicts that imprinting evolves due to differential genetic relatedness between maternal and paternal relatives. The studies produce a list of imprinted genes with around 120-180 in mice and approximate to 100 in humans. The studies agree on broad patterns across mice and humans including the complex patterns of imprinted expression at loci like Igf2 and Grb10. We discuss how the kinship theory provides a powerful framework for hypotheses that can explain these patterns. Finally, since imprinting is rare in the genome despite predictions from the kinship theory that it might be common, we discuss evolutionary factors that could favor biallelic expression.
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