Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes
出版年份 2016 全文链接
标题
Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes
作者
关键词
-
出版物
BIOESSAYS
Volume 38, Issue 7, Pages 664-673
出版商
Wiley
发表日期
2016-05-31
DOI
10.1002/bies.201600084
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval
- (2015) Claudia Tamar Silva et al. HUMAN GENETICS
- A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
- (2015) Lars G Fritsche et al. NATURE GENETICS
- Rare variant association studies: considerations, challenges and opportunities
- (2015) Paul L Auer et al. Genome Medicine
- Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach
- (2015) Andrés Castellanos-Martín et al. GENOME BIOLOGY
- Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus
- (2014) S N Kariuki et al. GENES AND IMMUNITY
- Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
- (2014) Gerald I. Shulman NEW ENGLAND JOURNAL OF MEDICINE
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Pleiotropy in complex traits: challenges and strategies
- (2013) Nadia Solovieff et al. NATURE REVIEWS GENETICS
- Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy
- (2013) Peter Libby NEW ENGLAND JOURNAL OF MEDICINE
- Credible Mendelian Randomization Studies: Approaches for Evaluating the Instrumental Variable Assumptions
- (2012) M. M. Glymour et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Elements of ‘missing heritability’
- (2012) Ali J. Marian CURRENT OPINION IN CARDIOLOGY
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer
- (2012) Julius Gudmundsson et al. NATURE GENETICS
- Genetic Association Analysis of Complex Diseases Incorporating Intermediate Phenotype Information
- (2012) Yafang Li et al. PLoS One
- The mystery of missing heritability: Genetic interactions create phantom heritability
- (2012) O. Zuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies
- (2012) Daniel Shriner Frontiers in Genetics
- Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms
- (2011) Ellen S. Regalado et al. CIRCULATION RESEARCH
- Strategic Approaches to Unraveling Genetic Causes of Cardiovascular Diseases
- (2011) A.J. Marian et al. CIRCULATION RESEARCH
- Environment-Sensitive Epigenetics and the Heritability of Complex Diseases
- (2011) Robert E. Furrow et al. GENETICS
- Initial impact of the sequencing of the human genome
- (2011) Eric S. Lander NATURE
- Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma
- (2011) Iñaki Comino-Méndez et al. NATURE GENETICS
- Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
- (2011) Manuel A Rivas et al. NATURE GENETICS
- The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms
- (2011) Günter P. Wagner et al. NATURE REVIEWS GENETICS
- Exome sequencing as a tool for Mendelian disease gene discovery
- (2011) Michael J. Bamshad et al. NATURE REVIEWS GENETICS
- K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
- (2011) M. Choi et al. SCIENCE
- Pervasive Sharing of Genetic Effects in Autoimmune Disease
- (2011) Chris Cotsapas et al. PLoS Genetics
- General Epistatic Models of the Risk of Complex Diseases
- (2010) Y. S. Song et al. GENETICS
- One Hundred Years of Pleiotropy: A Retrospective
- (2010) F. W. Stearns GENETICS
- Genomic Analysis of Mental Illness
- (2010) Jon McClellan et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- A map of human genome variation from population-scale sequencing
- (2010) Richard M. Durbin et al. NATURE
- Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome
- (2010) Sarah B Ng et al. NATURE GENETICS
- Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
- (2010) Nona Sotoodehnia et al. NATURE GENETICS
- Mendelian disorders and multifactorial traits: the big divide or one for all?
- (2010) Stylianos E. Antonarakis et al. NATURE REVIEWS GENETICS
- Uncovering the roles of rare variants in common disease through whole-genome sequencing
- (2010) Elizabeth T. Cirulli et al. NATURE REVIEWS GENETICS
- Network medicine: a network-based approach to human disease
- (2010) Albert-László Barabási et al. NATURE REVIEWS GENETICS
- Post-translational modifications in signal integration
- (2010) Yonathan Lissanu Deribe et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Genomics, Type 2 Diabetes, and Obesity
- (2010) Mark I. McCarthy NEW ENGLAND JOURNAL OF MEDICINE
- Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
- (2010) Silvia N Kariuki et al. ARTHRITIS RESEARCH & THERAPY
- Nature’s Genetic Gradients and the Clinical Phenotype
- (2009) Ali J. Marian Circulation-Cardiovascular Genetics
- Host Genetic Variation Affects Resistance to Infection with a Highly Pathogenic H5N1 Influenza A Virus in Mice
- (2009) A. C. M. Boon et al. JOURNAL OF VIROLOGY
- Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
- (2009) Paul Lichtenstein et al. LANCET
- Finding the missing heritability of complex diseases
- (2009) Teri A. Manolio et al. NATURE
- Exome sequencing identifies the cause of a mendelian disorder
- (2009) Sarah B Ng et al. NATURE GENETICS
- Genome-wide association study identifies eight loci associated with blood pressure
- (2009) Christopher Newton-Cheh et al. NATURE GENETICS
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
- (2009) Murim Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autoimmune Disease Classification by Inverse Association with SNP Alleles
- (2009) Marina Sirota et al. PLoS Genetics
- The Future of Mouse QTL Mapping to Diagnose Disease in Mice in the Age of Whole-Genome Association Studies
- (2008) Kent W. Hunter et al. Annual Review of Genetics
- Personal genomes: The case of the missing heritability
- (2008) Brendan Maher NATURE
- Sizing up human height variation
- (2008) Peter M Visscher NATURE GENETICS
- Common and rare variants in multifactorial susceptibility to common diseases
- (2008) Walter Bodmer et al. NATURE GENETICS
- Heritability in the genomics era — concepts and misconceptions
- (2008) Peter M. Visscher et al. NATURE REVIEWS GENETICS
- Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer
- (2008) Paul D.P. Pharoah et al. NEW ENGLAND JOURNAL OF MEDICINE
- The implications of human metabolic network topology for disease comorbidity
- (2008) D.- S. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Variation in an Individual Human Exome
- (2008) Pauline C. Ng et al. PLoS Genetics
- Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
- (2007) Debbie A. Lawlor et al. STATISTICS IN MEDICINE
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