Promoter engineering strategies for the overproduction of valuable metabolites in microbes

Systematic engineering for high-yield production of viridiflorol and amorphadiene in auxotrophic Escherichia coli

(2019) Sudha Shukal et al.   METABOLIC ENGINEERING

High-yield C11-oxidation of hydrocortisone by establishment of an efficient whole-cell system in Bacillus megaterium

(2019) Lisa König et al.   METABOLIC ENGINEERING

Advances in Industrial Biotechnology Using CRISPR-Cas Systems

(2018) Paul D. Donohoue et al.   TRENDS IN BIOTECHNOLOGY

Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli

(2018) Congqiang Zhang et al.   Nature Communications

Dynamic control of endogenous metabolism with combinatorial logic circuits

(2018) Felix Moser et al.   Molecular Systems Biology

Systematic Analysis of Bottlenecks in a Multibranched and Multilevel Regulated Pathway: The Molecular Fundamentals of l-Methionine Biosynthesis in Escherichia coli

(2018) Jian-Feng Huang et al.   ACS Synthetic Biology

Chromosome engineering of Escherichia coli for constitutive production of salvianic acid A

(2017) Liang Zhou et al.   Microbial Cell Factories

The application of powerful promoters to enhance gene expression in industrial microorganisms

(2017) Shenghu Zhou et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors

(2017) Ahmad A. Mannan et al.   ACS Synthetic Biology

Pichia pastoris Alcohol Oxidase 1 (AOX1 ) Core Promoter Engineering by High Resolution Systematic Mutagenesis

(2017) Rui M. C. Portela et al.   Biotechnology Journal

A Strong Hybrid Fatty Acid Inducible Transcriptional Sensor Built From Yarrowia lipolytica Upstream Activating and Regulatory Sequences

(2017) Murtaza Shabbir Hussain et al.   Biotechnology Journal

Study of in vitro transcriptional binding effects and noise using constitutive promoters combined with UP element sequences in Escherichia coli

(2017) Qiang Yan et al.   Journal of Biological Engineering

In situ enhancement of surfactin biosynthesis inBacillus subtilisusing novel artificial inducible promoters

(2016) Song Jiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering ofEscherichia colifor microbial production of L-methionine

(2016) Jian-Feng Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combinatorial optimization of CO2transport and fixation to improve succinate production by promoter engineering

(2016) Jun-Han Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multigene Pathway Engineering with Regulatory Linkers (M-PERL)

(2016) Duo Liu et al.   ACS Synthetic Biology

Characterization of Endogenous and Reduced Promoters for Oxygen-Limited Processes Using Escherichia coli

(2016) Alvaro R. Lara et al.   ACS Synthetic Biology

Synthetic Core Promoters as Universal Parts for Fine-Tuning Expression in Different Yeast Species

(2016) Rui M. C. Portela et al.   ACS Synthetic Biology

Promoters inducible by aromatic amino acids and γ-aminobutyrate (GABA) for metabolic engineering applications in Saccharomyces cerevisiae

(2015) Sujin Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of core promoter regions enables the construction of constitutive and inducible promoters in Halomonas sp.

(2015) Tingting Li et al.   Biotechnology Journal

Core promoter sequence in yeast is a major determinant of expression level

(2015) Shai Lubliner et al.   GENOME RESEARCH

Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction

(2015) Qian Liu et al.   METABOLIC ENGINEERING

Engineering of core promoter regions enables the construction of constitutive and inducible promoters in Halomonas sp.

(2015) Tingting Li et al.   Biotechnology Journal

Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria

(2014) Liliya Horbal et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Atmospheric and room temperature plasma (ARTP) as a new powerful mutagenesis tool

(2014) Xue Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production

(2014) John Blazeck et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The synthetic biology toolbox for tuning gene expression in yeast

(2014) Heidi Redden et al.   FEMS YEAST RESEARCH

Systematic metabolic engineering of Escherichia coli for high-yield production of fuel bio-chemical 2,3-butanediol

(2014) Youqiang Xu et al.   METABOLIC ENGINEERING

Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae

(2014) Luke N. Latimer et al.   METABOLIC ENGINEERING

Engineering anAcinetobacterregulon for biosensing and high-throughput enzyme screening inE. colivia flow cytometry

(2014) Ramesh K. Jha et al.   NUCLEIC ACIDS RESEARCH

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

(2014) P. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic engineering of Corynebacterium glutamicum for L-arginine production

(2014) Seok Hyun Park et al.   Nature Communications

Development and characterization of AND-gate dynamic controllers with a modular synthetic GAL1 core promoter inSaccharomyces cerevisiae

(2013) Wei Suong Teo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

(2013) Theresa Siegl et al.   METABOLIC ENGINEERING

Sequence features of yeast and human core promoters that are predictive of maximal promoter activity

(2013) Shai Lubliner et al.   NUCLEIC ACIDS RESEARCH

Composability of regulatory sequences controlling transcription and translation inEscherichia coli

(2013) Sriram Kosuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Core Promoters for Pichia pastoris

(2013) Thomas Vogl et al.   ACS Synthetic Biology

Using Synthetic Biological Parts and Microbioreactors to Explore the Protein Expression Characteristics of Escherichia coli

(2013) Thomas E. Gorochowski et al.   ACS Synthetic Biology

Constitutive Optimized Production of Streptokinase inSaccharomyces cerevisiaeUtilizing Glyceraldehyde 3-Phosphate Dehydrogenase Promoter ofPichia pastoris

(2013) Ravi N. Vellanki et al.   Biomed Research International

Generalizing a hybrid synthetic promoter approach in Yarrowia lipolytica

(2012) John Blazeck et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae

(2012) Jie Sun et al.   BIOTECHNOLOGY AND BIOENGINEERING

Controlling promoter strength and regulation inSaccharomyces cerevisiaeusing synthetic hybrid promoters

(2012) John Blazeck et al.   BIOTECHNOLOGY AND BIOENGINEERING

Promoter engineering: Recent advances in controlling transcription at the most fundamental level

(2012) John Blazeck et al.   Biotechnology Journal

Synthetic gene circuits for metabolic control: design trade-offs and constraints

(2012) D. A. Oyarzun et al.   Journal of the Royal Society Interface

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters

(2012) Eilon Sharon et al.   NATURE BIOTECHNOLOGY

Rational Diversification of a Promoter Providing Fine-Tuned Expression and Orthogonal Regulation for Synthetic Biology

(2012) Benjamin A. Blount et al.   PLoS One

Tuning Promoter Strength through RNA Polymerase Binding Site Design in Escherichia coli

(2012) Robert C. Brewster et al.   PLoS Computational Biology

GAPPromoter Library for Fine-Tuning of Gene Expression in Pichia pastoris

(2011) Xiulin Qin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tuning Gene Expression in Yarrowia lipolytica by a Hybrid Promoter Approach

(2011) John Blazeck et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A synthetic library of RNA control modules for predictable tuning of gene expression in yeast

(2011) A. H. Babiskin et al.   Molecular Systems Biology

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

(2011) Harry Yim et al.   Nature Chemical Biology

Regulation of Alternative Sigma Factor Use

(2010) Sofia Österberg et al.   Annual Review of Microbiology

Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology

(2010) James M. Clomburg et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence

(2010) J. B. Kinney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives

(2009) Akinori Matsushika et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering ofEscherichia colifor the production of polylactic acid and its copolymers

(2009) Yu Kyung Jung et al.   BIOTECHNOLOGY AND BIOENGINEERING

Regulation of gene expression via the core promoter and the basal transcriptional machinery

(2009) Tamar Juven-Gershon et al.   DEVELOPMENTAL BIOLOGY

High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis

(2009) Rupali P Patwardhan et al.   NATURE BIOTECHNOLOGY

Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability

(2009) M. D. Vinces et al.   SCIENCE

Analysis of combinatorial cis-regulation in synthetic and genomic promoters

(2008) Jason Gertz et al.   NATURE

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

(2008) Zengyi Shao et al.   NUCLEIC ACIDS RESEARCH

Promoter library designed for fine-tuned gene expression in Pichia pastoris

(2008) Franz S. Hartner et al.   NUCLEIC ACIDS RESEARCH