Article
Oncology
Bo Li, Ning Pu, Qiangda Chen, Yong Mei, Dansong Wang, Dayong Jin, Wenchuan Wu, Lei Zhang, Wenhui Lou
Summary: This study established a diagnostic nomogram based on postoperative objective parameters that can predict the development of CR-POPF after PD with good discriminative ability and predictive accuracy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jeffrey Chen, Tess M. E. van Ramshorst, Sanne Lof, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando M. Burdio, Giovanni Butturini, Riccardo Casadei, Andrea Coratti, Mathieu D'Hondt, Safi Dokmak, Bjorn Edwin, Alessandro Esposito, Jean M. Fabre, Giovanni Ferrari, Fadhel S. Fteriche, Giuseppe K. Fusai, Bas Groot Koerkamp, Thilo Hackert, Asif Jah, Jin-Young Jang, Emanuele F. Kauffmann, Tobias Keck, Alberto Manzoni, Marco Marino, Quintus Molenaar, Elizabeth Pando, Patrick Pessaux, Andrea Pietrabissa, Zahir Soonawalla, Robert P. Sutcliffe, Lea Timmermann, Steven White, Vincent S. Yip, Alessandro Zerbi, Mohammad Abu Hilal, Marc G. Besselink
Summary: RDP and LDP provide comparable R0-resection rate and overall survival in experienced centers for patients with resectable pancreatic cancer. Although RDP appears to have favorable lymph node yield and conversion rate, LDP is associated with shorter operating time, less major complications, and shorter hospital stay. The specific benefits associated with each approach should be confirmed by multicenter, randomized trials.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Amir Ashraf Ganjouei, Fernanda Romero-Hernandez, Jaeyun Jane Wang, Megan Casey, Willow Frye, Daniel Hoffman, Kenzo Hirose, Eric Nakakura, Carlos Corvera, Ajay V. Maker, Kimberly S. Kirkwood, Adnan Alseidi, Mohamed A. Adam
Summary: In this study, a user-friendly risk calculator was developed using machine learning algorithms and preoperatively known variables to predict clinically-relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD). The calculator can be used in the preoperative setting to inform clinical decision-making and patient counseling.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nicolas Tabchouri, Morgane Bouquot, Helene Hermand, Olivier Benoit, Jean-Christophe Loiseau, Safi Dokmak, Beatrice Aussilhou, Sebastien Gaujoux, Olivier Turrini, Jean Robert Delpero, Alain Sauvanet
Summary: This study developed a predictive risk score for POPF following PD, which could more specifically identify low-risk patients compared to existing scores. Preoperative radiation therapy was identified as an independent protective factor.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria-Chiara Ambrosetti, Alberto Ambrosetti, Giampaolo Perri, Clizia Gasparini, Giovanni Marchegiani, Roberto Salvia, Stefania Montemezzi, Giancarlo Mansueto, Giulia A. Zamboni
Summary: The objective of this study was to assess the correlation between pancreatic quantitative edge analysis and the incidence of postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy (PD). The results showed that patients with higher pancreatic stiffness and higher grade of POPF had higher scores in quantitative edge analysis. This suggests that quantitative edge analysis may help predict postoperative pancreatic fistula.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Yeon Jee Lee, Dong-Eun Lee, Jaekyung Bae, Hyeong In Ha, Myong Cheol Lim
Summary: This study aimed to analyze the outcomes and learning curve of single-site robot-assisted hysterectomy. The results showed that the procedure was safe and feasible, with a learning curve of 41 cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Kwang Yeol Paik, Ji Seon Oh, Eung Kook Kim
Summary: This study found that higher serum amylase level immediate after PD is correlated with POPF occurrence, with high fistula risk grade and post pancreatectomy acute pancreatitis being predictive factors for POPF. Comprehensive management is important for patients with higher serum amylase levels to mitigate the risk of POPF.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Benedetto Ielpo, Alessandro Anselmo, Yoshio Masuda, Mark Yeo Hao Xuan, Fernando Burdio, Vito De Blasi, Patricia Sanchez-Velazquez, Antonio Giuliani, Juan Santiago Azagra, Giuseppe Massimiliano Viola, Mauro Podda, Gianluca Pellino, Edoardo Rosso
Summary: This article introduces the superior mesenteric artery first approach in minimally invasive pancreaticoduodenectomy, and describes five different minimally invasive surgical methods. With the guidance provided, surgeons can choose the appropriate approach based on tumor location, type of minimally invasive surgery, and their own experience, thereby increasing familiarity with this complex procedure.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Benedetto Ielpo, Alessandro Anselmo, Yoshio Masuda, Mark Yeo Hao Xuan, Fernando Burdio, Vito De Blasi, Patricia Sanchez-Velazquez, Antonio Giuliani, Juan Santiago Azagra, Giuseppe Massimiliano Viola, Mauro Podda, Gianluca Pellino, Edoardo Rosso
Summary: This article describes the superior mesenteric artery first approach in minimally invasive pancreaticoduodenectomy, including five different minimally invasive approaches. For the first time, a comprehensive step-by-step overview of this approach is provided by a team of expert surgeons from various international institutions. The article aims to guide the choice of approach based on tumor location, type of minimally invasive approach, and the surgeon's experience, and increase familiarity with this complex procedure.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Fabian Schuh, Andre L. Mihaljevic, Pascal Probst, Maxwell T. Trudeau, Philip C. Muller, Giovanni Marchegiani, Marc G. Besselink, Faik Uzunoglu, Jakob R. Izbicki, Massimo Falconi, Carlos Fernandez-del Castillo, Mustapha Adham, Kaspar Z'graggen, Helmut Friess, Jens Werner, Jurgen Weitz, Oliver Strobel, Thilo Hackert, Dejan Radenkovic, Dezso Kelemen, Christopher Wolfgang, Y. Miao, Shailesh Shrikhande, Keith D. Lillemoe, Christos Dervenis, Claudio Bassi, John P. Neoptolemos, Markus K. Diener, Charles M. Vollmer, Markus W. Buchler
Summary: The aim of this study was to develop a classification system for pancreas-associated risk factors in pancreatoduodenectomy (PD). Based on a systematic literature search and data analysis, the International Study Group of Pancreatic Surgery (ISGPS) proposed a classification system based on pancreas-associated risk factors, which was validated in a large international cohort. For future pancreatic surgical outcomes studies, the ISGPS recommends reporting these risk factors according to the proposed classification system for better comparability of results.
Article
Surgery
Munseok Choi, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
Summary: The study analyzed a total of 171 patients who underwent LPDs and found that the learning curve can be divided into three phases: initial learning period, technical competence period, and challenging period, requiring 40 and 100 cases respectively to achieve the corresponding levels of expertise.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Medicine, General & Internal
Niklas Pakkasjarvi, Nellai Krishnan, Liisi Ripatti, Sachit Anand
Summary: The learning process of pediatric robot-assisted pyeloplasty (pRALP) requires a certain number of surgical cases to reach proficiency. Robot-assisted surgery is safe during the learning process, and "learning by doing" improves surgical efficiency. Future studies need to define competencies with broader implications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
DeFei Hong, HuaGen Li, XiaoLong Liu, Peiqiang Jiang, Guangsheng Yu, Xueqing Liu, Jianhua Liu, YaHui Liu, Jun Liu, Wan Yee Lau
Summary: This prospective multicenter study aimed to investigate the incidence of postoperative pancreatice fistula and the technique of pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy (LPD). The results showed that the pancreaticojejunostomy technique in LPD is safe, simple, and reproducible, with favorable clinical outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Juanita N. Chui, Ai-Jen Yang, Christopher B. Nahm, Saxon Connor, Anthony J. Gill, Jaswinder S. Samra, Anubhav Mittal
Summary: The authors did not receive any financial support for the research, authorship, and/or publication of this article.
Article
Multidisciplinary Sciences
Naotake Funamizu, Akimasa Sakamoto, Takeshi Utsunomiya, Mio Uraoka, Tomoyuki Nagaoka, Miku Iwata, Chihiro Ito, Kei Tamura, Katsunori Sakamoto, Kohei Ogawa, Yasutsugu Takada
Summary: GNRI has the potential to predict postoperative complications and prognosis in patients with resectable pancreatic cancer, with GNRI values below 99 being significantly associated with poor outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Yuanchi Weng, Jiabin Jin, Zhen Huo, Yusheng Shi, Yu Jiang, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: Robotic-assisted distal pancreatectomy has advantages in operative time, blood loss, spleen preservation, infection rate, and gastrointestinal function recovery over open distal pancreatectomy for treating benign and low-grade malignant pancreatic tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Yuanchi Weng, Yu Jiang, Ningzhen Fu, Jiabin Jin, Yusheng Shi, Zhen Huo, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: Robot-assisted minimally invasive surgery for PDAC showed comparable disease-free survival and overall survival outcomes to open surgery in a propensity score-matched analysis. Further confirmation through prospective randomized controlled trials is needed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Yusheng Shi, Qingrou Wang, Zhihao Shi, Junjie Xie, Jiabin Jin, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: This study compared the short-term and long-term outcomes between robot-assisted middle pancreatectomy (RMP) and robot-assisted distal pancreatectomy (RDP), with RDP showing advantages in short-term outcomes, especially in reducing the rate of clinical-relevant postoperative pancreatic fistula (CR-POPF).
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2021)
Article
Oncology
Yusheng Shi, Xinjing Wang, Weize Wu, Junjie Xie, Jiabin Jin, Chenghong Peng, Xiaxing Deng, Hao Chen, Baiyong Shen
Summary: This study evaluated prognostic factors of patients with resectable pancreatic adenosquamous cancer and found that the survival rate was low, with a 5-year survival rate of only 11.6%. Normal serum levels of Ca199 and Ca125 were identified as independent favorable prognostic factors for predicting prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ningzhen Fu, Weishen Wang, Dongfeng Cheng, Jiancheng Wang, Zhiwei Xu, Xiaxing Deng, Chenghong Peng, Hao Chen, Baiyong Shen
Summary: This study proposed a rescue staging system for pancreatic ductal adenocarcinoma patients with inadequate lymph node examination after pancreatoduodenectomy. The system showed better predictive capacity than the 8th AJCC staging system, as demonstrated by higher C-index values in both SEER and RJPDC databases.
Article
Cell Biology
Zengyu Feng, Kexian Li, Jianyao Lou, Mindi Ma, Yulian Wu, Hao Chen, Chenghong Peng
Summary: The study aims to develop a DNA replication-related gene signature to stratify PDAC patients treated with R0 resection based on recurrence risks. Pathway enrichment analysis suggests a close relationship with cell cycle, DNA replication, and DNA repair, potentially aiding in the identification of novel biomarkers and therapeutic targets for PDAC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zengyu Feng, Peng Chen, Kexian Li, Jianyao Lou, Yulian Wu, Tao Li, Chenghong Peng
Summary: This study developed an effective prognostic signature using ferroptosis-related genes to predict PDAC recurrence. The signature showed stability and independence in both training and validation cohorts, outperforming clinical indicators and previous models. Additionally, the signature was closely associated with multiple cancer-related and drug response pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Editorial Material
Oncology
Weishen Wang, Ziyun Shen, Jun Zhang, Hao Chen, Xiaxing Deng, Chenghong Peng, Junjie Xie, Zhiwei Xu, Baiyong Shen
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Weishen Wang, Ziyun Shen, Jun Zhang, Hao Chen, Xiaxing Deng, Chenghong Peng, Junjie Xie, Zhiwei Xu, Baiyong Shen
Summary: The study found that examining a minimum of 19 lymph nodes is crucial for ensuring quality lymph node detection and long-term survival in patients undergoing distal pancreatectomy for pancreatic ductal adenocarcinoma. The ideal cut-off value for lymph node examination was identified using Kaplan-Meier survival analysis and X-tile software.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jiewei Lin, Shuyu Zhai, Siyi Zou, Zhiwei Xu, Jun Zhang, Lingxi Jiang, Xiaxing Deng, Hao Chen, Chenghong Peng, Jiaqiang Zhang, Baiyong Shen
Summary: The study found that FLVCR1-AS1 is downregulated in PC tissues and cell lines, and its overexpression suppresses proliferation, cell cycle, and migration of PC cells. Mechanistically, FLVCR1-AS1 acts as a ceRNA to sequester miR-513c-5p or miR-514b-5p from KLF10 mRNA, relieving their suppressive effects on KLF10 expression. Additionally, FLVCR1-AS1 was shown to be a direct transcriptional target of KLF10, suggesting a novel therapeutic strategy for PC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Surgery
Jiabin Jin, Shih-min Yin, Yuanchi Weng, Mengmin Chen, Yusheng Shi, Xiayang Ying, Georgios Gemenetzis, Kai Qin, Jun Zhang, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: This study compared the outcomes of venous resection and reconstruction (VR) in robotic-assisted and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adenocarcinoma (PDAC). The results showed similar reconstructed venous patency, postoperative complications, and 90-day mortality between the two groups, but the robotic group had a lower lymph node resection rate.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Medicine, Research & Experimental
Jiabin Jin, Yusheng Shi, Mengmin Chen, Jianfeng Qian, Kai Qin, Zhen Wang, Wei Chen, Weiwei Jin, Fengchun Lu, Zheyong Li, Zehua Wu, Li Jian, Bing Han, Xiao Liang, Chuandong Sun, Zheng Wu, Yiping Mou, Xiaoyu Yin, Heguang Huang, Hao Chen, Georgios Gemenetzis, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: The PORTAL trial is a multicenter randomized controlled trial comparing the outcomes of robotic pancreatoduodenectomy (RPD) and open pancreatoduodenectomy (OPD) in China. The trial will assess primary and secondary outcomes, as well as sub-cohort analysis of pancreatic adenocarcinoma (PDAC) patients.
Article
Medicine, General & Internal
Qian Zhan, Chenlei Wen, Yi Zhao, Lu Fang, Yangbing Jin, Zehui Zhang, Siyi Zou, Fanlu Li, Ying Yang, Lijia Wu, Jiabin Jin, Xiongxiong Lu, Junjie Xie, Dongfeng Cheng, Zhiwei Xu, Jun Zhang, Jiancheng Wang, XiaXing Deng, Hao Chen, Chenghong Peng, Hongwei Li, Henghui Zhang, Hai Fang, Chaofu Wang, Baiyong Shen
Summary: The study revealed limited prognostic value of point mutations in highly mutated genes or homologous recombination repair genes in PAAD patients, while amplified genes involved in DNA repair and RTK related signalings were associated with worse prognosis. Molecular subtyping and prognostic model construction can stratify patients with low or high risk of relapse more effectively.
Article
Biochemistry & Molecular Biology
Shuyu Zhai, Zhiwei Xu, Junjie Xie, Jun Zhang, Xinjing Wang, Chenghong Peng, Hongwei Li, Hao Chen, Baiyong Shen, Xiaxing Deng
Summary: LINC00261 has been identified as a tumor suppressor in pancreatic cancer, inhibiting cancer progression through various mechanisms including inducing cell cycle arrest and apoptosis. Its expression levels are closely associated with pathological stage and prognosis, revealing its crucial role and regulatory mechanisms in pancreatic cancer.