期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 48, 期 7, 页码 2028-2039出版社
SPRINGER
DOI: 10.1007/s10439-019-02383-1
关键词
Transdermal delivery; Needle-free injection; Thermocavitation; Solid needle injection; Topical application; Laser micro-jet
资金
- Royal Dutch Society of Sciences (KHMW)
Drug diffusion within the skin with a needle-free micro-jet injection (NFI) device was compared with two well-established delivery methods: topical application and solid needle injection. A permanent make-up (PMU) machine, normally used for dermal pigmentation, was utilized as a solid needle injection method. For NFIs a continuous wave (CW) laser diode was used to create a bubble inside a microfluidic device containing a light absorbing solution. Each method delivered two different solutions into ex vivo porcine skin. The first solution consisted of a red dye (direct red 81) and rhodamine B in water. The second solution was direct red 81 and rhodamine B in water and glycerol. We measured the diffusion depth, width and surface area of the solutions in all the injected skin samples. The NFI has a higher vertical dispersion velocity of 3 x 10(5)mu m/s compared to topical (0.1 mu m/s) and needle injection (53 mu m/s). The limitations and advantages of each method are discussed, and we conclude that the micro-jet injector represents a fast and minimally invasive injection method, while the solid needle injector causes notable tissue damage. In contrast, the topical method had the slowest diffusion rate but causes no visible damage to the skin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据