期刊
BIOCONJUGATE CHEMISTRY
卷 27, 期 11, 页码 2646-2657出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.6b00405
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资金
- SBIR grant from the National Cancer Institute [R43 CA119399]
- Maryland Technology Development Corporation (TEDCO) Development and Pilot Manufacturing for Multi-functional Tumor Targeting Nanomedicine
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNF alpha), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.
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