期刊
ANGIOLOGY
卷 71, 期 2, 页码 167-174出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319719887655
关键词
prediabetes; HbA(1c); FBG; glycosylated hemoglobin A(1c); fasting blood glucose; coronary atherosclerosis; SYNTAX score
资金
- National Key Research and Development Program of China [2017YFC0908800]
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20150601]
- Beijing Municipal Health Commission Project of Science and Technology Innovation Center [PXM2019_026272_000006, PXM2019_026272_000005]
- Beijing Municipal Administration of Hospitals' Mission plan [SML20180601]
Diabetes mellitus, and even prediabetes, has been shown to be independently associated with cardiovascular disease. Our study explored whether the combination of glycosylated hemoglobin (HbA(1c)) and fasting blood glucose (FBG) can better assess the severity of coronary heart disease (CHD) in elective percutaneous coronary intervention (PCI) patients. We consecutively enrolled 1006 prediabetic patients with HbA(1c) 5.7% to 6.4% who underwent elective PCI. Patients were divided into 2 groups: a normal fasting glucose (NFG) group (FBG <6.1 mmol/L) and an impaired fasting glucose (IFG) group (6.1 <= FBG<7.0 mmol/L) with defined values. Baseline characteristics and angiography data of the 2 groups were compared. The prevalence of 3-vessel disease (P = .002), the GENSINI (the score is named after a professor) score (P = .002), and the SYNTAX (SYNergy between PCI with TAXUS (TM) and Cardiac Surgery) score (P = .002) of the IFG group was significantly higher compared to the NFG group. After multiple regression analysis, FBG was found to be independently associated with prevalence of 3-vessel disease (adjusted odds ratio: 1.62; 95% confidence interval: 1.21-2.36; P = .013), the GENSINI score (standardized beta = .138, P = .008), and the SYNTAX score (standardized beta = .145, P = .005). In addition, HbA(1)(c) was independently associated with the prevalence of 3-vessel disease, the GENSINI, score, and the SYNTAX score (P < .05). Both FBG and HbA(1c) are independently correlated with the severity of CHD in prediabetic patients with HbA(1c) 5.7% to 6.4%.
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