期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 13, 页码 6890-6918出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909927
关键词
aptamers; bioimaging; biosensing; DNAzymes; functional nucleic acids
资金
- U.S. National Institute of Health [GM124316, MH110975]
- National Science and Technology Major Project of China [2018ZX08012-001]
- National Natural Science Foundation Project of China [31671922]
Functional nucleic acid (FNA) nanotechnology focuses on studying the interactions between FNAs and nanomaterials, aiming to create advanced biomaterials with unique properties for various applications in bioimaging, biosensing, biomedicine, and other important fields.
Functional nucleic acid (FNA) nanotechnology is an interdisciplinary field between nucleic acid biochemistry and nanotechnology that focuses on the study of interactions between FNAs and nanomaterials and explores the particular advantages and applications of FNA nanomaterials. With the goal of building the next-generation biomaterials that combine the advantages of FNAs and nanomaterials, the interactions between FNAs and nanomaterials as well as FNA self-assembly technologies have established themselves as hot research areas, where the target recognition, response, and self-assembly ability, combined with the plasmon properties, stability, stimuli-response, and delivery potential of various nanomaterials can give rise to a variety of novel fascinating applications. As research on the structural and functional group features of FNAs and nanomaterials rapidly develops, many laboratories have reported numerous methods to construct FNA nanomaterials. In this Review, we first introduce some widely used FNAs and nanomaterials along with their classification, structure, and application features. Then we discuss the most successful methods employing FNAs and nanomaterials as elements for creating advanced FNA nanomaterials. Finally, we review the extensive applications of FNA nanomaterials in bioimaging, biosensing, biomedicine, and other important fields, with their own advantages and drawbacks, and provide our perspective about the issues and developing trends in FNA nanotechnology.
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