期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 6, 页码 2328-2332出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201913743
关键词
alkenes; asymmetric catalysis; carboamination; nickel; synthetic methods
资金
- NSFC [21702102, 21772087]
- NSF of Jiangsu Province [BK20190281]
- Fundamental Research Funds for the Central Universities [020514380182]
Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of beta-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis.
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