Article
Chemistry, Multidisciplinary
Wei Zhu, Miaomiao Kang, Qian Wu, Zhijun Zhang, Yi Wu, Chunbin Li, Kai Li, Lei Wang, Dong Wang, Ben Zhong Tang
Summary: A novel NIR-emissive zwitterionic luminogen with AIE features was designed and synthesized for cancer phototheranostics, showing excellent performance in NIR-II fluorescence imaging-guided synergistic phototherapy against cancer, due to its long emission wavelength, effective ROS generation, and high photothermal conversion efficiency.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shanliang Song, Yue Zhao, Miaomiao Kang, Zhijun Zhang, Qian Wu, Shuang Fu, Youmei Li, Haifei Wen, Dong Wang, Ben Zhong Tang
Summary: The innovative design of versatile cancer phototheranostics utilizing fluorescence imaging (FLI) and photodynamic and photothermal therapies (PDT, PTT) has sparked interest. By employing side-chain engineering, researchers successfully developed an AIE-active multifunctional phototheranostic system (TBFT2 nanoparticles) for FLI-guided PDT and PTT synergistic cancer therapy, showcasing the potential of side-chain engineering in creating superior versatile phototheranostics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pei Li, Xuewen He, Yang Li, Jacky Wing Yip Lam, Ryan Tsz Kin Kwok, Cun Chuan Wang, Li Gang Xia, Ben Zhong Tang
Summary: Photoacoustic imaging (PAI) is a rapidly developing modality in biomedical research, offering noncontact operation, high optical resolution, and deep penetration. Organic agents, especially aggregation-induced emission (AIE)-active contrast agents, show great potential for PAI applications due to their excellent in vivo properties. This paper provides an overview of recent progress in AIE-based agents in the field of PAI, discussing their basic concepts, data comparison, trends, and perspectives. AIE-based PAI agents are believed to be promising multifunctional theranostic platforms in clinical fields, facilitating significant advancements in this research topic.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Yingcai Hu, Sheng-Yan Yin, Zuhao Li, Wenchen Qi, Yun Chen, Jishan Li
Summary: In this study, a quinolinyl-AIE photosensitizer with alternative elevated ISC rate was designed and synthesized, showing highly efficient photosensitivity, tumor cell specificity, and excellent mitochondrial targeting ability. In vitro experiments demonstrated that the photosensitizer induced tumor cell death with low radiation dose, while exhibiting no obvious toxicity to normal cells. In vivo studies on a mouse model also verified the high efficiency of this photosensitizer in PDT.
CHEMICAL COMMUNICATIONS
(2022)
Article
Spectroscopy
Yinchan Wang, Weihua Zhuang, Sisi Wu, Zhenyu Duan, Shufen Li, Jingruo Chen, Linsen Zhou, Yongjie Zhou, Chengming Li, Mao Chen
Summary: Selective labelling of the plasma membrane (PM) using a carbazole-based probe CPPPy allows for intuitive analysis of cell status and dynamic changes. CPPPy selectively accumulates at the PM of living cells and can light up the PM even at a low concentration. It also has potential for photodynamic therapy in tumor cells. This study provides new insights into the development of multifunctional fluorescence probes for PM-specific bioimaging and photodynamic therapy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Engineering, Biomedical
Xiangfang Lin, Wei Li, Yongqiang Wen, Lei Su, Xueji Zhang
Summary: Photoluminescence imaging (PLI) is a valuable non-invasive visualization technique in biological applications. Aggregation-induced emission (AIE)-active nanocomposites have emerged as promising agents for bioimaging and photodynamic therapy (PDT). This review focuses on the progress and applications of AIE-active nanocomposites for intracellular process monitoring and PLI-guided PDT.
Article
Chemistry, Applied
Wen Li, Meina Huang, Yuan Li, Zhigang Yang, Junle Qu
Summary: Three newly designed aggregation-induced emission luminogens show potential as photosensitizers, with TPA2CN exhibiting higher O-1(2) generation efficiency and photoluminescence quantum yield in nano-micelles. Bio-micelles demonstrate comparable O-1(2) generation capability to commercial photosensitizer chlorin e6 in solution, with efficient reactive oxygen species generation in live cells and effective cancer cell ablation in vivo.
Article
Chemistry, Multidisciplinary
Sichao Tian, Jiangling He, Da Lyu, Shuang Li, Qing-Hua Xu
Summary: Metal nanoparticle conjugates with aggregated induced emission show enhanced therapeutic effects for cancer treatment, making them attractive multifunctional agents.
Article
Chemistry, Multidisciplinary
Yize Zhang, Junjun Wang, Shen Wang, Xiaojiao Zhu, Zhipeng Yu, Zhichao Wu, Jianhua Yu, Hongping Zhou
Summary: The strategy of planarization and donor rotation was applied to design a series of D-pi-A systems, optimizing intramolecular charge transfer and non-radiative transitions to enhance photoacoustic and photothermal properties and improve ICT effect for multi-modal imaging-guided therapy in vivo.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Materials Science, Biomaterials
Guanyu Ding, Jialin Tong, Jianye Gong, Zhiming Wang, Zhongmin Su, Lu Liu, Xu Han, Jianguo Wang, Lingyu Zhang, Xinlong Wang, Li-Li Wen, Guo-Gang Shan
Summary: In this study, three AIEgens with near-infrared (NIR) emission and efficient reactive oxygen species (ROS) generation ability were designed and synthesized using molecular engineering. These photosensitizers showed strong long-wavelength emission and the ability to produce ROS under white light irradiation. One of the photosensitizers, TBP-SO3, demonstrated faster ROS generation ability and specific endoplasmic reticulum targeting, making it an excellent candidate for photodynamic therapy treatment of cancer cells and bacteria.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Applied
Liucheng Mao, Hongye Huang, Danning Hu, Haijun Ma, Mei Tian, Xiaoyong Zhang, Yen Wei
Summary: A novel near-infrared aggregation-induced emission (AIE) fluorescent bioprobe TPA-diCN-F127 NPs with desirable characteristics such as near-infrared emission, large Stokes shift, good dispersibility, and biocompatibility was prepared in this study. Efficient cancer cell damage was demonstrated in vitro upon white light irradiation, indicating the potential capability of TPA-diCN-F127 NPs in imaging-guided PDT.
Article
Chemistry, Multidisciplinary
Junyu Chen, Liucheng Mao, Yuming Jiang, Huihui Liu, Xiao Wang, Lingwei Meng, Qiuyao Du, Jing Han, Liuying He, Hongye Huang, Yawei Wang, Caiqiao Xiong, Yen Wei, Zongxiu Nie
Summary: Simultaneous imaging and analysis of exogenous nanomaterials and endogenous metabolites in tissue was achieved using label-free mass spectrometry imaging. This approach allowed for the identification of heterogeneous deposition and clearance behaviors of nanoparticles in organs, as well as the detection of distinct endogenous metabolic changes in normal tissues. It was found that the accumulation of nanoparticles in tumors did not benefit from abundant tumor vessels. Additionally, spatial-selective metabolic changes were observed during nanoparticle-mediated photodynamic therapy, shedding light on the mechanism of apoptosis induction in cancer therapy.
Article
Chemistry, Multidisciplinary
Ming-Yu Wu, Luojia Chen, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen, Meijia Gu
Summary: This study proposes a novel strategy for the treatment of sepsis by combining aggregation-induced emission photosensitizer (AIE-PS) with phages. This strategy effectively removes pathogenic bacteria through a nucleophilic substitution reaction. It retains phage's host specificity and possesses fluorescence imaging and reactive oxygen species (ROS) characteristics for bacteria detection and sterilization. It shows superior bactericidal efficacy in animal models and can quickly diagnose blood infections in clinical samples.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Haixing Shi, Xiaohong Pan, Yaqi Wang, Huanhuan Wang, Wenzhen Liu, Le Wang, Zhuo Chen
Summary: The study proposes a new design strategy to enhance the fluorescence and reactive oxygen species (ROS) generation of aggregation-induced emission photosensitizers (AIE-PSs) by restricting the rotation of certain bonds. Through the development of carbazole group-based AIE-PSs, significant improvements in fluorescence, ROS generation, and antibacterial abilities were achieved. CPVBP3 demonstrated the ability to enter bacterial cells for antibacterial effects, which is a unique function not commonly reported. The low light dose required for CPVBP2 to kill Staphylococcus aureus indicates promising prospects for AIE antimicrobial photosensitizers.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Liu, Bingnan Wang, Yuewen Yu, Yubo Liu, Zeyan Zhuang, Zujin Zhao, Guangxue Feng, Anjun Qin, Ben Zhong Tang
Summary: This article introduces a molecular cationization approach to enhance the generation of reactive oxygen species (ROS) by aggregation-induced emission (AIE) photosensitizers, especially type I ROS, for photodynamic treatment of drug-resistant bacteria.
Article
Chemistry, Multidisciplinary
Xingang Liu, Min Wu, Meng Wang, Yukun Duan, Chi Uyen Phan, Huan Chen, Guping Tang, Bin Liu
Summary: Research has shown the potential of neutrophil-based nanotherapeutic engineering in treating infection and inflammation disorders. A new method using AIEgen-lipid conjugates can efficiently label harvested neutrophils in just 30 seconds, without affecting their activation or transmigration properties, offering promising prospects for studies in neutrophil-based nanotherapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Chengjian Chen, Zhenguo Chi, Kok Chan Chong, Andrei S. Batsanov, Zhan Yang, Zhu Mao, Zhiyong Yang, Bin Liu
Summary: Commercial carbazole is commonly used to synthesize organic functional materials. An isomer of carbazole found in commercially produced batches is responsible for the ultralong phosphorescence observed in these compounds and their derivatives.
Editorial Material
Multidisciplinary Sciences
Wenbo Wu, Bin Liu
NATIONAL SCIENCE REVIEW
(2021)
Article
Chemistry, Multidisciplinary
Leilei Shi, Wenbo Wu, Yukun Duan, Li Xu, Sha Li, Xihui Gao, Bin Liu
Summary: Hybrid DNAzyme nanoparticles were developed for light-induced carrier-free self-delivery of DNAzymes with sufficient cofactor supply and lysosome escape capacity. Results showed that these nanoparticles could downregulate the EGR-1 protein to inhibit tumor cell growth and induce tumor cell apoptosis under light irradiation.
Article
Chemistry, Multidisciplinary
Yuanbo Wang, Shidang Xu, Leilei Shi, Cathleen Teh, Guobin Qi, Bin Liu
Summary: This study presents a cancer-cell-activated photosensitizer synthesis strategy to selectively synthesize efficient PS with mitochondria-targeting capability for potent cancer-cell-specific ablation under light irradiation, ensuring high specificity and safety for post-treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Lingyue Shen, Ting Zhu, Lidan Hou, Xiangjun Meng, Bin Liu
Summary: Photodynamic therapy is a promising noninvasive treatment for patients with superficial tumors, with AIEPS5-NPs-NB showing superior 1O2 generation, bright emission, and targeted delivery capabilities in comparison to traditional PS nanoparticles.
Article
Chemistry, Physical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Xihui Gao, Xinyuan Zhu, Bin Liu
Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Junru Chen, Xiaojie Chen, Lei Cao, Huangjun Deng, Zhenguo Chi, Bin Liu
Summary: In this study, an efficient ultralong organic phosphorescent molecule with the longest lifetime and brightest ultralong organic phosphorescence (UOP) was synthesized through structural modification and intramolecular halogen bond. The research reveals that the generation and accumulation of triplet excitons play a crucial role in achieving efficient UOP materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Kenry, Linhao Sun, Trifanny Yeo, Eshu Middha, Yuji Gao, Chwee Teck Lim, Shinji Watanabe, Bin Liu
Summary: A study on the real-time observation of the dynamic cellular effects of phospholipid nanoparticles reveals their ability to selectively modulate the edge motility, surface roughness, and dynamic deformation profiles of cells. This provides important insights for improving the formulation of phospholipid nanoparticles for various bioapplications.
Article
Multidisciplinary Sciences
Kenry
Summary: Bioinspired and biomimetic nanostructures have gained significant interest for theranostic and nanomedicine applications. Peptide surface functionalization and biomineralization of nanomaterials offer a viable strategy due to the availability and ease of modification. However, conventional peptide screening methods suffer from drawbacks. This study presents a framework using unsupervised and supervised machine learning to accelerate peptide analysis and selection for engineering functional nanostructures.
ADVANCED THEORY AND SIMULATIONS
(2023)
Article
Multidisciplinary Sciences
Peng Wang, Jiang Liu, Xiaomei Zhu, Zhengqing Kenry, Zhengqing Yan, Jiahui Yan, Jitong Jiang, Manlin Fu, Jingyan Ge, Qing Zhu, Yuguo Zheng
Summary: Cyclic peptides have attracted attention in the pharmaceutical industry, but there are limited methods for their synthesis. This study presents an efficient and direct method for peptide cyclization using rhodium(III)-catalyzed C(7)-H maleimidation. The resulting cyclic peptides exhibit higher bioactivity and can be used for creating peptide-drug conjugates.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kenry, Bin Liu
Summary: Photodynamic therapy utilizes photosensitizers, light, and reactive oxygen species to induce cytotoxicity and cell death, but organic photosensitizers tend to suffer from reduced singlet oxygen production when these molecules aggregate. To address this issue, a new class of organic photosensitizers with aggregation-induced emission characteristics has been developed, and can enhance the efficacy of photodynamic therapy through different design strategies.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Kenry, Benjamin K. Eschle, Bohdan Andreiuk, Prafulla C. Gokhale, Samir Mitragotri
Summary: This study systematically investigates the interactions between different-shaped AuNSs and macrophages of different phenotypes. The results reveal that the morphology of AuNSs significantly affects their interactions with macrophages, including macrophage viability, oxidative stress response, cytokine release, and phagocytic ability. The selective response of macrophages, particularly the M1-like phenotype, towards AuNSs may have implications for cancer immunotherapy.
ADVANCED THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Xingang Liu, Yukun Duan, Bin Liu
Summary: Nanoparticles as contrast agents for photoacoustic imaging in the diagnosis of brain-related pathologies show potential applications, but design considerations such as absorption capacity, biocompatibility, photothermal conversion efficiency, nanostructure control, and targeting ability need to be carefully considered. Challenges in developing more robust and universal contrast agents for enhanced photoacoustic imaging are discussed for future perspectives.
Article
Materials Science, Multidisciplinary
Chengjian Chen, Kok Chan Chong, Yutong Pan, Guobin Qi, Shidang Xu, Bin Liu
Summary: Research indicates that the origin of carbazole has a significant impact on the photoluminescence quantum yield of its derivatives. Commercially sourced carbazole activates efficient radiative transition pathways, leading to a substantial increase in quantum yield.
ACS MATERIALS LETTERS
(2021)