期刊
BIOCHIMIE
卷 125, 期 -, 页码 250-258出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2015.09.005
关键词
Phosphoinositides; Cell signaling; Lipids; Pathologies; Phosphoinositide-metabolizing enzymes; PI3K
资金
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV2-0004-01]
- Association pour la Recherche contre le Cancer (ARC)
- Inserm
- la ligue contre le cancer
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV2-0004] Funding Source: Agence Nationale de la Recherche (ANR)
By interacting specifically with proteins, phosphoinositides organize the spatiotemporal formation of protein complexes involved in the control of intracellular signaling, vesicular trafficking and cytoskeleton dynamics. A set of specific kinases and phosphatases ensures the production, degradation and inter conversion of phosphoinositides to achieve a high level of precision in the regulation of cellular dynamics coordinated by these lipids. The direct involvement of these enzymes in cancer, genetic or infectious diseases, and the recent arrival of inhibitors targeting specific phosphoinositide kinases in clinic, emphasize the importance of these lipids and their metabolism in the biomedical field. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据