期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1864, 期 9, 页码 1152-1159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2016.06.003
关键词
Bacillomycin L; Iturin; Rhizoctonia solani Kuhn; Proteome; Antibiotics
资金
- National Natural Science Foundation of China [31172001]
- Special Fund for Agro-scientific Research in the Public Interest of China [201303014]
Bacillomycin L, a natural iturinic lipopeptide produced by Bacillus amyloliquefaciens, is characterized by strong antifungal activity against a variety of agronomically important filamentous fungi including Rhizoctonia solani Kuhn To further understand its antifungal actions, proteomes were comparatively studied within R. solani hyphal cells treated with or without bacillomycin L The results show that 39 proteins were alternatively expressed within cells in response to this lipopeptide, which are involved in stress response, carbohydrate, amino acid and nucleotide metabolism, cellular component organization, calcium homeostasis, protein degradation, RNA processing, gene transcription, and others, suggesting that, in addition to inducing cell membrane permeabilization, iturin exhibits antibiotic activities by targeting intracellular molecules. Based on these results, a model of action of bacillomycin L against R. solani hyphal cells was proposed. Our study provides new insight into the antibiotic mechanisms of iturins. (C) 2016 Elsevier B.V. All rights reserved.
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