Article
Cell Biology
Wenguang Liu, Alexander S. Brodsky, Meng Feng, Yajun Liu, Jing Ding, Chathuraka T. Jayasuriya, Qian Chen
Summary: Aging OA-MSC in human osteoarthritic cartilage can lead to cell senescence, fibrosis, and inflammation, expressing a pro-inflammatory senescence associated secretory phenotype that may contribute to OA pathogenesis. OAC acts as the main recipient of inflammatory signals by expressing receptors of cytokines. Through replication-driven OAC dedifferentiation and MSC senescence, OA-MSC becomes an internal source of sterile inflammation in human cartilage joint.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Robert C. H. Gresham, Andrea C. Filler, Shierly W. Fok, Molly Czachor, Natalie Schmier, Claire Pearson, Chelsea Bahney, J. Kent Leach
Summary: In this study, the researchers cultured senescent MSCs on different substrates and found that the senescent phenotype of MSCs decreased when cultured on compliant substrates, and their conditioned media promoted osteoblast mineralization. These findings provide new insights for improving autologous cell therapies for older donors.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Biotechnology & Applied Microbiology
Yesuf Siraj, Umberto Galderisi, Nicola Alessio
Summary: Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells that can differentiate into mesodermal derivatives. MSCs have therapeutic effects due to their secretome, which has anti-inflammatory and regenerative properties. However, when MSCs become senescent, their secretome can acquire pro-inflammatory and pro-aging activities, which should be considered in therapeutic applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, Kazuhiro Tamura
Summary: PGRMC1 is involved in cellular senescence during decidualization through the regulation of FOXO1 expression.
Article
Biochemistry & Molecular Biology
Clara Bernardelli, Silvia Ancona, Melania Lazzari, Antonella Lettieri, Piera Selvaggio, Valentina Massa, Cristina Gervasini, Fabiano Di Marco, Raffaella Chiaramonte, Elena Lesma
Summary: This study examines the role of senescence in lymphangioleiomyomatosis (LAM), a rare disease characterized by the disruption of lung parenchyma. Through experiments on LAM cells and lung fibroblasts, the authors demonstrate the senescent features of LAM cells and their impact on neighboring cells. This finding provides important insights into the development and progression of LAM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kazuya Kusama, Naoya Yamauchi, Kanoko Yoshida, Mana Azumi, Mikihiro Yoshie, Kazuhiro Tamura
Summary: Decidualization, a crucial step for embryo implantation and placentation, can be enhanced by senolytic agents such as Quercetin and Dasatinib. Treatment with a combination of these agents synergistically increases the expression of decidualization markers and senescence markers in decidualizing ESCs, offering a potential therapeutic strategy for infertility related to endometrial receptivity and embryo implantation dysfunctions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Yiwen Zha, Wenwen Zhuang, Yongqi Yang, Yue Zhou, Hongliang Li, Jingyan Liang
Summary: Vascular smooth muscle cells (VSMCs) play a crucial role in the development of atherosclerosis, and senescent VSMCs are found in both aged vessels and atherosclerotic plaques. Factors associated with atherosclerosis, such as oxidative stress, inflammation, and calcium-regulating factors, are closely linked to senescence in VSMCs. While previous studies have suggested the potential use of anti-aging drugs for treating atherosclerosis, recent doubts have arisen due to the complexity of VSMCs and the lack of specific markers for cellular aging. Further research is needed to reevaluate the efficacy of anti-aging drugs in atherosclerosis treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Lun-Yin Chou, Chun-Te Ho, Shih-Chieh Hung
Summary: This study reveals that late MSCs display senescence features and that proinflammatory cytokines from late MSCs contribute to the cellular senescence of early MSCs via paracrine signaling, ultimately impairing their functionality.
Article
Biochemistry & Molecular Biology
Helene Martini, Lise Lefevre, Sylvain Sayir, Romain Itier, Damien Maggiorani, Marianne Dutaur, Dimitri J. Marsal, Jerome Roncalli, Nathalie Pizzinat, Daniel Cussac, Angelo Parini, Jeanne Mialet-Perez, Victorine Douin-Echinard
Summary: Systolic cardiac dysfunction in Tg MAOA mice is strongly correlated with oxidative stress-induced premature senescence of cardiac stromal cells, promoting recruitment of CCR2(+) monocytes and the development of cardiac inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Svetlana Lyamina, Denis Baranovskii, Ekaterina Kozhevnikova, Tatiana Ivanova, Sergey Kalish, Timur Sadekov, Ilya Klabukov, Igor Maev, Vadim Govorun
Summary: Life expectancy and age-related diseases burden have significantly increased in recent decades. The majority of age-associated ailments, such as diabetes, cardiovascular diseases, and neurodegeneration, are closely related to tissue nonspecific inflammation triggered by mesenchymal stromal cell secretion. The secretion of mesenchymal stromal cells has been proposed as an ideal tool for cell-free regenerative therapy and tissue engineering, but senescent mesenchymal stromal cells' secretome plays a key role in inflammaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Sven E. Niklander, Daniel W. Lambert, Keith D. Hunter
Summary: Cellular senescence has attracted attention for its association with aging, age-related diseases, and cancer. Senescent cells cannot proliferate but develop a harmful pro-inflammatory secretome known as SASP. Evidence suggests senescent cells contribute to carcinogenesis in different anatomical sites, leading to the development of senotherapeutics as a potential cancer treatment strategy.
Article
Oncology
Jian-Wei Zhang, Dan Zhang, Bao-Ping Yu
Summary: Cellular senescence is a stress response that can have detrimental effects during cancer therapy, including promoting tumorigenesis and therapeutic resistance. Selective removal of senescent cells is considered a promising adjuvant approach to eliminate these adverse effects.
Article
Obstetrics & Gynecology
P. Deryabin, A. Borodkina
Summary: Senescence of endometrial stromal cells (EnSC) contributes to impaired endometrial decidualization and impaired interaction with trophoblast cells. Application of senomorphics can diminish the adverse effects of senescent EnSC on decidualization and implantation.
HUMAN REPRODUCTION
(2022)
Article
Cell Biology
Miguel Rovira, Rebecca Sereda, David Pladevall-Morera, Valentina Ramponi, Ines Marin, Mate Maus, Julio Madrigal-Matute, Antonio Diaz, Fernando Garcia, Javier Munoz, Ana Maria Cuervo, Manuel Serrano
Summary: The lysosomal proteome of senescent cells undergoes significant changes, and some senescent cells can be highly active in lysosomal exocytosis.
Article
Biochemistry & Molecular Biology
Chieh Ming Liao, Tianjiao Luo, Juliane von der Ohe, Blanca de Juan Mora, Roland Schmitt, Ralf Hass
Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Pavel Deryabin, Anastasiia Griukova, Nikolay Nikolsky, Aleksandra Borodkina
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Cell Biology
Larisa Alekseenko, Mariia Shilina, Irina Kozhukharova, Olga Lyublinskaya, Irina Fridlyanskaya, Nikolay Nikolsky, Tatiana Grinchuk
Article
Cell Biology
Pavel Deryabin, Alisa Domnina, Inga Gorelova, Maxim Rulev, Mariya Petrosyan, Nikolay Nikolsky, Aleksandra Borodkina
Summary: This study focuses on developing a genetic tool for patient-specific optimization of hormonal supplementation during the luteal phase to maintain endometrial receptivity. Utilizing a cell differentiation model and RNA sequencing, the research identified a core decidual regulatory network that reflects the sensitivity of the endometrium to steroid hormones.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alla N. Shatrova, Elena B. Burova, Marianna V. Kharchenko, Irina S. Smirnova, Olga G. Lyublinskaya, Nikolay N. Nikolsky, Aleksandra V. Borodkina
Summary: Mesenchymal stem cells (MSCs) are widely used in regenerative therapy to replace damaged cells, but their low survival rate after transplantation is a major limitation. Strategies to prevent stress-induced apoptosis have been developed, but little attention has been paid to senescence as another common stress reaction of MSCs. Preconditioning human endometrial stem cells (hMESCs) with deferoxamine (DFO) can prevent oxidative stress-induced senescence, preserving all the properties of the initial hMESCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pavel Deryabin, Alla N. Shatrova, Aleksandra Borodkina
Summary: Cardiac glycosides have been shown to be effective senolytics, but they do not have senolytic ability towards senescent hMSCs from different origins. Senescent hMSCs avoid senolysis by increasing apoptosis resistance and weakening antiapoptotic defense.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Obstetrics & Gynecology
P. Deryabin, A. Borodkina
Summary: Senescence of endometrial stromal cells (EnSC) contributes to impaired endometrial decidualization and impaired interaction with trophoblast cells. Application of senomorphics can diminish the adverse effects of senescent EnSC on decidualization and implantation.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Pavel Deryabin, Aleksandra Borodkina
Summary: This study focuses on the importance of uterine ageing and the use of epigenetic clocks to measure the age of endometrial tissues. Research indicates an age-related functional decline in endometrial tissue, which can be predicted through adjusting the clocks.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Biochemistry & Molecular Biology
Pavel Deryabin, Alla N. Shatrova, Aleksandra Borodkina
Summary: In this study, a novel approach for senolysis was proposed, which involved disturbing multiple homeostasis-maintaining systems in senescent cells. The ionophore nigericin was found to be able to disrupt several key cellular processes simultaneously, leading to senolytic action towards senescent cells of different origins. The senolytic effect of nigericin was independent of the senescence-inducing stimuli. The study also suggested an interval dosing strategy to minimize negative effects on control cells and maximize the senolytic effect of nigericin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
P. Deryabin, J. S. Ivanova, A. Borodkina
Summary: Successful implantation requires a finely tuned dialog between the invading embryo and the maternal endometrium. Premature senescence of endometrial stromal cells (EnSC) can lead to defective decidual transformation and impaired endometrial-blastocyst interaction. Senescent EnSC exhibit elevated intracellular reactive oxygen species (ROS) levels, originating from mitochondrial dysfunction and insufficient antioxidant defense. This imbalance in ROS release affects neighboring trophoblast-like cells, leading to DNA damage and potentially impacting embryo migration and invasion.
MOLECULAR HUMAN REPRODUCTION
(2022)
Meeting Abstract
Cell Biology
Anastasiia Griukova, Pavel Deryabin, Alla Shatrova, Aleksandra Borodkina
CELL DEATH DISCOVERY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
P. Deryabin, A. Griukova, A. Shatrova, A. Borodkina
Meeting Abstract
Biochemistry & Molecular Biology
A. Griukova, P. Deryabin, A. Shatrova, I. Guzhova, B. Margulis, A. Borodkina
Meeting Abstract
Cell Biology
Larisa L. Alekseenko, Mariia A. Shilina, Irina V. Kozhukharova, Olga G. Lyublinskaya, Valentina P. Ivanova, Nikolay N. Nikolsky, Tatiana M. Grinchuk
CELL DEATH DISCOVERY
(2020)