期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1863, 期 5, 页码 984-991出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2015.09.032
关键词
Peroxisomal division; Peroxisomal morphogenesis; Growth and division; Peroxisome turnover; Pexophagy; Adaptor protein
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Takeda Science Foundation
- Japan Foundation for Applied Enzymology
- [24247038]
- [25112518]
- [25116717]
- [26116007]
- [15K14511]
- [26440102]
- [15K18501]
- Grants-in-Aid for Scientific Research [15K14511, 26116007, 26440102] Funding Source: KAKEN
Peroxisome number and quality are maintained by its biogenesis and turnover and are important for the homeostasis of peroxisomes. Peroxisomes are increased in number by division with dynamic morphological changes including elongation, constriction, and fission. In the course of peroxisomal division, peroxisomal morphogenesis is orchestrated by Pexi11 beta, dynamin-like protein 1 (DLP1), and mitochondrial fission factor (Mff). Conversely, peroxisome number is reduced by its degradation. Peroxisomes are mainly degraded by pexophagy, a type of autophagy specific for peroxisomes. Upon pexophagy, an adaptor protein translocates on peroxisomal membrane and connects peroxisomes to autophagic machineries. Molecular mechanisms of pexophagy are well studied in yeast systems where several specific adaptor proteins are identified. Pexophagy in mammals also proceeds in a manner dependent on adaptor proteins. In this review, we address the recent progress in studies on peroxisome morphogenesis and pexophagy. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. (C) 2015 Elsevier B.V. All rights reserved.
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