期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 51, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201904992
关键词
biodegradable; colorectal lesions; endoscopy; fluorescent nanoparticles; imaging
类别
资金
- Will-Foundation Berlin
- Canary Center for Early Detection Seed Grant
- NCI CCNE [U54 CA199075]
- Canary Foundation
- Deutsche Krebshilfe-Grant [111902]
- German Research Society (Deutsche Forschungsgemeinschaft
- DFG) [Sonderforschungsbereich-824 (SFB-824/3 2017)]
- Deutsche Forschungsgemeinschaft [SFB 1335, SFB 1371]
- National Science Foundation [ECCS-1542152]
- [1R01 CA182043-01A1]
Early and comprehensive endoscopic detection of colonic dysplasia-the most clinically significant precursor lesion to colorectal adenocarcinoma-provides an opportunity for timely, minimally invasive intervention to prevent malignant transformation. Here, the development and evaluation of biodegradable near-infrared fluorescent silica nanoparticles (FSN) that have the potential to improve adenoma detection during fluorescence-assisted white-light colonoscopic surveillance in rodent and human-scale models of colorectal carcinogenesis is described. FSNs are biodegradable (t(1/2) of 2.7 weeks), well-tolerated, and enable detection and delineation of adenomas as small as 0.5 mm(2) with high tumor-to-background ratios. Furthermore, in the human scale, APC(1311/+) porcine model, the clinical feasibility and benefit of using FSN-guided detection of colorectal adenomas using video-rate fluorescence-assisted white-light endoscopy is demon-strated. Since nanoparticles of similar size (e.g., 100-150 nm) or composition (i.e., silica and silica/gold hybrid) have already been successfully translated to the clinic, and clinical fluorescent/white-light endoscopy systems are becoming more readily available, there is a viable path towards clinical translation of the proposed strategy for early colorectal cancer detection and prevention in high-risk patients.
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