Review
Chemistry, Inorganic & Nuclear
Ya-Lin Qi, Yun-Zhan Li, Ming-Jun Tan, Fang-Fang Yuan, Niren Murthy, Yong-Tao Duan, Hai-Liang Zhu, Sheng-Yu Yang
Summary: In recent years, there has been great interest in the development of organic near-infrared (NIR) ratiometric fluorescent probes. Traditional intensity-based probes lack an internal standard method, resulting in unreliable and inaccurate detection signals as well as an inability to achieve quantitative determination of analytes. Smart dual emission probes with built-in correction ability have overcome the limitations of single channel fluorescent probes and enable reliable quantitative image analysis. Moreover, fluorescent chemosensors in the NIR window offer advantages such as high signal-to-noise ratio, low tissue damage, and deep tissue penetration. The combination of the advantages of ratiometric fluorescent probes and single-intensity-based NIR probes in NIR ratiometric fluorescent probes has led to their widespread application in biomedical research and clinical practice. This review provides a systematic summary of the recent advances (2020-2022) in this field, discussing the design strategies, sensing mechanisms, and bioapplications of these intelligent fluorescent probes. The challenges and prospects in this promising field are also addressed, with the anticipation that this work will inspire the development of organic NIR ratiometric fluorescent probes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Kanyi Pu
Summary: Near-infrared (NIR) fluorescence imaging shows great potential in both basic biomedical research and clinical practice, especially in the diagnosis of nephron-urological diseases. The development of molecular probes has improved detection specificity and contrast enhancement in imaging.
Review
Chemistry, Multidisciplinary
Mengyao Zhao, Benhao Li, Hongxin Zhang, Fan Zhang
Summary: Fluorescence imaging in the second near-infrared (NIR-II) window allows for deeper penetration in bio-tissues with high optical resolution, highlighting the advantages of activatable sensors over non-responsive sensors in achieving high detection sensitivity and reliability in bio-sensing. The challenges, opportunities, and prospects of NIR-II activatable bio-sensing are also discussed.
Article
Chemistry, Organic
Tianzhu Wang, Zhiyong Jiang, Zhipeng Liu
Summary: In this study, a class of 1,4-bisvinylbenzene-bridged BODIPY dimers with fluorescence emission in the second near-infrared window (NIR-II, 1000-1700 nm) were reported. These dyes exhibit excellent NIR-II fluorescence properties and can be easily functionalized to achieve good water-solubility or tumor-targeting ability. In vivo imaging results demonstrate their high resolution and deep-penetration NIR-II imaging ability, making them promising NIR-II imaging agents.
Review
Materials Science, Multidisciplinary
Mingxia Jiao, Arsenii S. Portniagin, Xiliang Luo, Lihong Jing, Buxing Han, Andrey L. Rogach
Summary: Semiconductor nanocrystals emitting in the NIR-II window are promising fluorophores for biomedical applications due to their high brightness, adjustable emission wavelength, and stability. This review summarizes recent advances in the synthesis of NIR-II emitting semiconductor nanocrystals and highlights efforts to improve their emission intensity and photostability. It also provides examples of their applications in biomedical imaging, therapy, and surgery.
ADVANCED OPTICAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Qing Shen, Leichen Wang, Xiaohong Ruan, Na Li, Weili Wang, Wenjun Wang, Jinjun Shao, Xiaochen Dong
Summary: Photoacoustic (PA) imaging is a promising biomedical imaging technique that combines the advantages of high-contrast optical imaging and deep tissue penetration of acoustic imaging. This review focuses on the recent research progress of stimuli-responsive organic NIR probes for PA imaging, including temperature, pH, redox, metal ion, and enzyme response. The stimuli-responsive mechanisms are highlighted, and the perspectives and challenges are discussed.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yonglin He, Shenglong Liao, Yapei Wang
Summary: This article highlights the importance of light harvesting and photothermal materials in improving light use efficiency particularly in the NIR window, as well as thermally dependent applications established on photothermal conversion. The research group mainly focuses on the concept of green electronics based on ionic liquids and the study of photothermal materials and their related applications. The management approach of the research team includes giving more attention to younger students at the beginning of their research career and allowing senior students more freedom, while also enabling students to choose research interests based on their background.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Engineering, Chemical
Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun-Seok Lee, Marc Vendrell
Summary: This research optimized a general synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Qian Wu, Qian-Hui Zhou, Wei Li, Tian-Bing Ren, Xiao-Bing Zhang, Lin Yuan
Summary: This study developed a highly sensitive fluorescent probe NIR-beta gal-2 for the accurate diagnosis of breast carcinoma and differentiating tumors from normal tissues during surgery. The probe demonstrated superior sensitivity, affinity, and catalytic efficiency for fi-galactosidase. The probe was successfully applied for intraoperative guided excision of breast tumors and showed promising results for prognostic recovery.
Review
Chemistry, Inorganic & Nuclear
Yu Cai, Yi Pan, Longcai Liu, Tian Zhang, Chen Liang, Xiaozhou Mou, Xiangming Ye, Wenjun Wang, Xiaochen Dong
Summary: This article provides a comprehensive review of the development of croconic acid (CA)-based near-infrared (NIR) materials in the field of biomedical applications. The rational structure design of CA molecules for excellent NIR optical properties and the formation of CA dye-based nanomaterials for improved bioavailability and stability are introduced. The biomedical applications of CA-based functional materials, including photothermal therapy, photoacoustic imaging, phototheranostics, and multimodal treatment, are summarized. The perspectives and potential drawbacks of CA-based materials for future clinical transformation are systematically discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Luyan Wu, Yusuke Ishigaki, Wenhui Zeng, Takashi Harimoto, Baoli Yin, Yinghan Chen, Shiyi Liao, Yongchun Liu, Yidan Sun, Xiaobo Zhang, Ying Liu, Yong Liang, Pengfei Sun, Takanori Suzuki, Guosheng Song, Quli Fan, Deju Ye
Summary: The response of tumors to radiotherapy or ferroptosis is closely linked to hydroxyl radical production, and accurate imaging of this reactive oxygen species may allow for monitoring of therapy response. A ratiometric probe has been developed for in vivo imaging of hydroxyl radical generation, providing a reliable method for monitoring treatment response in tumors undergoing erastin-induced ferroptosis or radiotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Cheng Zeng, Yi Long, Yunyan Tan, Fang Zeng, Shuizhu Wu
Summary: Edible crops are vital for food security and sustainable agriculture. However, contamination of water and soil by heavy metal ions, especially cadmium (Cd), can have detrimental effects on the growth of these crops. Cd is widely used in industries and has become the most important metal ion in soil and water pollution. When Cd ions enter edible crops, it induces oxidative stress, which inhibits their growth. Therefore, accurately monitoring oxidative stress induced by Cd ions in edible crops is of great significance.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jianlong Ma, Xiaofeng Lu, Yong Guo, Zhijun Wang
Summary: This study synthesized a near-infrared (NIR) Cys-special probe (MCyA) that could precisely and quickly detect Cys activity. The observations showed that the endogenous Cys activity was depressed under oxidative stress, but dramatically increased with omeprazole stimulation in HepG2 cells. MCyA was also successfully used to image the upregulation of Cys level in HepG2 cells in the presence of methionine (Met). Overall, MCyA is a novel and practical tool to study Cys-related physiological and pathological processes.
Article
Biophysics
Jinya Du, Shuangshuang Yang, Yuchun Qiao, Huiting Lu, Haifeng Dong
Summary: The emergence of photoacoustic imaging (PAI) has greatly expanded the application of biomolecules bioimaging, especially in near-infrared (NIR) PAI which shows great potential in biomedical applications. Comparing different imaging modalities and focusing on the strategies used to improve contrast and performance in NIR-PAI are essential for enhancing imaging accuracy. Challenges and prospects in accelerating the development of PAI are identified to attract more researchers in this field.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Jie Tang, Liqun Dai, Xinyu He, Jie Li, Larry Cai, Ping Liao, Ruotian Jiang, Jingwei Zhou, Haoxing Wu
Summary: A novel strategy has been developed to create highly fluorescent Huaxi-Fluor probes that exhibit significantly increased fluorescence upon forming the bioorthogonal reaction product, pyridazine. These probes have large Stokes shifts and high quantum yields, with emission wavelengths fine-tunable from 556 to 728 nm by manipulating the fluorophore skeleton. Highly photo-stable and biocompatible, these probes are suitable for live cell organelle visualization without washing steps and imaging tumors in live small animals to depths of 500 μm by two-photon excitation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Deling Li, Qiang Liu, Qingrong Qi, Hui Shi, En-Chi Hsu, Weiyu Chen, Wenli Yuan, Yifan Wu, Sien Lin, Yitian Zeng, Zunyu Xiao, Lingyun Xu, Yanrong Zhang, Tanya Stoyanova, Wang Jia, Zhen Cheng
Review
Pharmacology & Pharmacy
Xin-Xin Zhang, Shi-Hao He, Xu Liang, Wei Li, Tian-Fang Li, Dai-Feng Li
Summary: Osteoarthritis is a chronic joint disease characterized by cartilage destruction, with aging playing a key role. Current treatments are palliative, and there is a need for disease-modifying drugs. Cellular senescence, synovial inflammation, and epigenetic changes may contribute to its pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shan-Shan Li, Shi-Hao He, Peng-Yu Xie, Wei Li, Xin-Xin Zhang, Tian-Fang Li, Dai-Feng Li
Summary: Osteoporosis is a chronic bone disease characterized by decreased bone mass and increased risk of fractures. Current treatment involves anti-resorptive drugs like bisphosphonates, but there is ongoing research into anabolic drugs and different signaling pathways for more effective and less toxic therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Baisong Chang, Daifeng Li, Ying Ren, Chunrong Qu, Xiaojing Shi, Ruiqi Liu, Hongguang Liu, Jie Tian, Zhenhua Hu, Taolei Sun, Zhen Cheng
Summary: The development of a NIR-II phosphorescent probe made of glutathione-capped copper-indium-selenium nanotubes enables enhanced tumor-specific imaging in acidic environments, offering superior imaging performance in the second near-infrared spectral window.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Ying Yuan, Shanchao Diao, Xiaoyue Ni, Dong Zhang, Wanrong Yi, Chao Jian, Xiang Hu, Daifeng Li, Aixi Yu, Wen Zhou, Quli Fan
Summary: This study developed semiconductor polymer nanoparticles for targeted photothermal therapy and photodynamic therapy in osteosarcoma. The nanoparticles showed efficient cellular uptake and enhanced therapeutic effects, leading to significant anti-tumor activities both in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Daifeng Li, Chi Zhang, Xiaoyan Tai, Denghui Xu, Jianzhong Xu, Pengfei Sun, Quli Fan, Zhen Cheng, Yi Zhang
Summary: This study developed a novel nanoplatform, P2NPs, with strong photothermal therapy and dual-modal optical tracking capabilities. In vitro and in vivo experiments demonstrated the potential of this platform in the treatment of osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Pengfei Sun, Fan Qu, Chi Zhang, Pengfei Cheng, Xiangyu Li, Qingming Shen, Daifeng Li, Quli Fan
Summary: This study presents a phototheranostic approach using NIR-II excitation for breast cancer bone metastases. The approach combines NIR-II fluorescence imaging, NIR-II photoacoustic imaging, NIR-II photothermal therapy, chemotherapy, and chemodynamic therapy. The phototheranostic successfully suppresses tumor cell progression in bone tissue and provides insights for the development of NIR-II phototheranostics.
Review
Chemistry, Multidisciplinary
Yaping He, Daifeng Li, Li Wu, Xianzhen Yin, Xiaojian Zhang, Laurence H. Patterson, Jiwen Zhang
Summary: Gene therapy shows promise in treating cancer, viral infection, and gene disorders, while genetic detection is crucial for disease diagnosis and prevention. However, the existing delivery vectors have limitations. Metal-organic frameworks (MOFs) have gained attention for their high surface areas and tunable structures. This review highlights the potential of MOFs as nonviral vectors in gene delivery and detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Daifeng Li, Shengnan Ma, Denghui Xu, Xiaocao Meng, Ningjing Lei, Chen Liu, Ying Zhao, Yingqiu Qi, Zhen Cheng, Fazhan Wang
Summary: In this study, a self-assembled nanoplatform named GENP was designed using stearic acid-modified GE11. The nanoplatform showed high drug loading efficiency and sustained drug release, and it significantly suppressed the proliferation of TNBC cells via inhibiting the PI3K/AKT signaling pathway downstream of EGFR. Further experiments demonstrated remarkable therapeutic efficacy with minimal biotoxicity in TNBC and its bone metastasis models.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Yaping He, Xuanzong Wang, Chi Zhang, Junkui Sun, Jianzhong Xu, Daifeng Li
Summary: A controllable antibacterial nanoplatform was constructed using cyclodextrin metal-organic frameworks (CD-MOFs) as a template to synthesize ultrafine silver nanoparticles (Ag NPs) in their porous structure. Polydopamine (PDA) was encapsulated on the CD-MOFs' surface to enhance water stability and enable hyperthermia capacity. The resulting Ag@MOF@PDA exhibited localized hyperthermia and controllable release of Ag+ for antibacterial activity.
Article
Engineering, Biomedical
Pengfei Sun, Wan Yang, Jiarong He, Liuliang He, Pengfei Chen, Wenjuan Xu, Qingming Shen, Daifeng Li, Quli Fan
Summary: In this study, multifunctional nanoparticles were developed for combined chemotherapy, photothermal therapy, and starvation therapy. The nanoparticles released drugs through donor-acceptor coordination interactions and PBA-diol bonds under acidic and oxidizing conditions. Additionally, 2-DG in the nanoparticles enhanced the therapeutic effects.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Pengfei Chen, Fan Qu, Liuliang He, Mingfei Li, Pengfei Sun, Quli Fan, Chi Zhang, Daifeng Li
Summary: By modifying with multiple sulfonate groups, a bone-targeted NIR-II small molecule (TTQF-SO3) was successfully synthesized for bone imaging. In vitro studies demonstrated its high affinity for hydroxyapatite and excellent macrophage accumulation ability. In vivo assays showed that TTQF-SO3 exhibited high bone uptake ability and high NIR-II bone imaging quality, highlighting its specific bone-targeting ability.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xuanzong Wang, Chi Zhang, Liuliang He, Mingfei Li, Pengfei Chen, Wan Yang, Pengfei Sun, Daifeng Li, Yi Zhang
Summary: The researchers proposed a novel nanoplatform for the synergistic use of photothermal therapy, chemodynamic therapy, and antibiotics in the treatment of drug-resistant bacterial biofilm infections. The nanoplatform caused damage to bacterial membrane structures through the release of antibiotics and generation of hydroxyl radicals in an acidic environment, and exhibited excellent hyperthermia and accelerated drug release under laser irradiation. Additionally, the nanoplatform enabled precise imaging of the infected sites.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Xin-Xin Zhang, Xu Liang, Sen-Rui Li, Kuang-Jin Guo, Dai-Feng Li, Tian-Fang Li
Summary: GC-induced avascular osteonecrosis of femoral head (AOFH) is a devastating complication without available cures. Modified bone marrow mesenchymal stem cell (BMMSCs) implantation can improve treatment efficacy by interfering with the COX-2-PGE-2-HIF-1α pathway and preventing AOFH.
CELL TRANSPLANTATION
(2022)
Article
Materials Science, Biomaterials
Lili Yang, Shanshan Liu, Jingjing Chu, Shuang Miao, Kai Wang, Qingwei Zhang, Yingyi Wang, Yadi Xiao, Lina Wu, Yang Liu, Longjian Yu, Caihong Yu, Xiang Liu, Mingxing Ke, Zhen Cheng, Xilin Sun
Summary: EGFR-targeted F-MPG and OH-MPG exhibit promising anti-tumor activity in NSCLC treatment with limited liver damage, making them promising drug candidates for further investigation in combating the deadly NSCLC.
BIOMATERIALS SCIENCE
(2021)