期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1862, 期 5, 页码 992-1007出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2015.11.010
关键词
Alzheimer's; Neurovascular aging; Target of rapamycin; MTOR; Aging; Geroscience
资金
- Veterans Administration Research and Development Merit Award [I01 BX002211-01A2]
- NIA Nathan Shock Center of Excellence in the Biology of Aging [2 P30 AG013319-21]
- Robert L Bailey and Daughter Lisa K. Bailey Alzheimer's Fund
- William & Ella Owens Medical Research Foundation
- JMR Barker Foundation
- San Antonio Medical Foundation
- National Center for Advancing Translational Sciences, NIH [UL TR001120]
- Robert A. Welch Distinguished Chair Endowment in the Department of Biochemistry [AQ0039]
Aging is the strongest known risk factor for Alzheimer's disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulation of aging and the mechanisms of specific age-associated diseases can be identified. We will review emerging evidence that mTOR-dependent brain vascular dysfunction, a universal feature of aging, may be one of the mechanisms linking the regulation of the rate of aging to the pathogenesis of Alzheimer's disease. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. Published by Elsevier B.V.
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