期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1862, 期 12, 页码 2259-2269出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2016.07.002
关键词
Ubiquitin ligases; Autophagy; Metabolism; Heart failure; Therapy; Ubiquitin-proteasome system
资金
- National Institutes of Health [R01HL104129]
- Jefferson-Pilot Corporation
- Leducq Foundation Transatlantic Networks of Excellence
Both the ubiquitin-proteasome system (UPS) and the lysosomal autophagy system have emerged as complementary key players responsible for the turnover of cellular proteins. The regulation of protein turnover is critical to cardiomyocytes as post-mitotic cells with very limited regenerative capacity. In this focused review, we describe the emerging interface between the UPS and autophagy, with E3's regulating autophagy at two critical points through multiple mechanisms. Moreover, we discuss recent insights in how both the UPS and autophagy can alter metabolism at various levels, to present new ways to think about therapeutically regulating autophagy in a focused manner to optimize disease-specific cardioprotection, without harming the overall homeostasis of protein quality control. This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason RB. Dyck & Jan P.C. Glatz. (C) 2016 Elsevier B.V. All rights reserved.
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