Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chin-Feng Tsai, Hui-Wen Lin, Jiuan-Miaw Liao, Ke-Min Chen, Jen-Wei Tsai, Chia-Sung Chang, Chia-Yu Chou, Hsing-Hui Su, Pei-Hsun Liu, Ya-Chun Chu, Yi-Hsin Wang, Meilin Wang, Shiang-Suo Huang
Summary: This study found that D. salina extract can alleviate myocardial ischemia/reperfusion (I/R) injury and exert anti-inflammatory and anti-apoptotic effects through inhibiting TLR4-mediated signaling pathway, while reducing autophagy activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Guo-Yuan He, Chen-Hui Zhao, De-Gang Wu, Hao Cheng, Le-An Sun, De-Long Zhang, Xin-Jie Yang, Xi-Ran Fan, Guang-Fu Di, Xiao-Chun Jiang
Summary: The study revealed that S100A8 activates the TLR4-MyD88 pathway, leading to inflammation in the brain after TBI, which is crucial for understanding the inflammatory mechanisms post-TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Elise E. Bruning, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
Summary: TLR4 is a highly conserved protein involved in innate immunity with distinct roles in epithelial and immune cells throughout the gastrointestinal tract. While epithelial cell expression of TLR4 contributes to maintaining homeostasis, promoting immunoglobulin A production, and regulating permeability, immune cell expression is centered on maturation of dendritic cells and priming the adaptive immune system. However, further research is needed to fully understand the impact of site-specific TLR4 expression on inflammation and disease progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Upadhyayula Suryanarayana Murty, V. G. M. Naidu, Bidya Dhar Sahu
Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.
Article
Hematology
Francesco Barilla, Vittoria Cammisotto, Simona Bartimoccia, Lorenzo Loffredo, Cristina Nocella, Noemi Bruno, Concetta Torromeo, Paolo Rosa, Nicola Viceconte, Pasquale Pignatelli, Carlo Gaudio, Roberto Carnevale, Francesco Violi
Summary: This study provides evidence that platelet toll-like receptor 4 (TLR4) is activated in patients with myocardial infarction (MI) and suggests circulating lipopolysaccharides (LPS) as a potential trigger.
THROMBOSIS RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Plant Sciences
Min Cai, You-cai Xu, Bo Deng, Jun-Bang Chen, Ting-Fang Chen, Ke-Feng Zeng, Si Chen, Sui-hui Deng, Zhang-bin Tan, Wen-jun Ding, Shuang-wei Zhang, Bin Liu, Jing-zhi Zhang
Summary: This study found that GL extract and its active constituent LicoA exerted anti-inflammatory effects by targeting TLR4 directly, reducing inflammatory damage and inhibiting TLR4 signaling activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Reza Badalzadeh
Summary: This study investigates the interaction between aging and cardioprotection induced by combination therapy with coenzyme Q(10) (CoQ(10)) and mitochondrial transplantation in myocardial ischemia/reperfusion (I/R) injury of aged rats. The results show that the combination of CoQ(10) and mitochondrial transplantation attenuates myocardial I/R injury in aged rats by modulating autophagy and inflammatory response, thereby restoring the aging-related loss of cardioprotection in aged patients.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Natsumi Ogawa, Shingo Nakajima, Kenya Tamada, Natsuki Yokoue, Haruki Tachibana, Miwa Okazawa, Takahiro Oyama, Hideaki Abe, Hiroaki Yamazaki, Atsushi Yoshimori, Akira Sato, Takanori Kamiya, Takehiko Yokomizo, Fumiaki Uchiumi, Takehiko Abe, Sei-ichi Tanuma
Summary: The spasmolytic drug trimebutine has shown potential as an anti-inflammatory agent in experiments, reducing the production of various proinflammatory factors and significantly decreasing mortality in a mouse model of sepsis. Studies have found that trimebutine exerts its anti-inflammatory effects by inhibiting TLR signaling pathways and NF-kappa B activity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Vishwadeep Shelke, Neha Dagar, Anil Bhanudas Gaikwad
Summary: Combination therapy of phloretin and losartan is more effective in treating AKI under diabetic condition by inhibiting TLR4-associated inflammation and AT1R-associated mitochondrial dysfunction.
Review
Biochemistry & Molecular Biology
Saahithh Redddi Patlola, Gary Donohoe, Declan P. McKernan
Summary: Toll-like receptors (TLRs) are pattern recognition receptors that protect the brain from self and foreign antigens/pathogens and can elicit a harmful or beneficial immune response. TLR activation has been associated with neurodegenerative diseases and cytokine imbalance in schizophrenia. This review explores the current literature on TLRs, their potential role in schizophrenia pathogenesis, factors affecting TLR activity and their impact on cognitive performance in schizophrenia.
Article
Immunology
Huanyu Jiang, Yubiao Zhang, Geliang Hu, Xiaobin Shang, Jianghua Ming, Ming Deng, Yaming Li, Yonggang Ma, Shiqing Liu, Yan Zhou
Summary: The study reveals the important role of surfactant protein D (SP-D) in regulating inflammation and immune response in osteoarthritis (OA). SP-D exhibits chondroprotective properties by downregulating inflammation-related genes, suppressing cytokine production, and reducing infiltration of inflammatory cells. The binding of SP-D to the TLR4/MD-2 complex further inhibits TLR4-mediated signaling activation. These findings suggest that SP-D has a beneficial effect in attenuating inflammation and preserving cartilage integrity in OA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Antonio Hernandez, Naeem K. Patil, Maya Brewer, Rachel Delgado, Lauren Himmel, Lauren N. Lopez, Julia K. Bohannon, Allison M. Owen, Edward R. Sherwood, Mark P. de Caestecker
Summary: This study aimed to investigate whether a novel Toll-like receptor 4 agonist could attenuate acute kidney injury induced by ischemia-reperfusion injury. The results showed that pretreatment with the agonist improved kidney function, reduced renal tissue injury and apoptosis. The findings suggest that the agonist can provide protection against ischemia-reperfusion injury-induced acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Review
Cell Biology
Bahareh Kashani, Zahra Zandi, Atieh Pourbagheri-Sigaroodi, Davood Bashash, Seyed H. Ghaffari
Summary: The TLR family is crucial for pattern recognition in innate immunity, with TLR4 playing a significant role in inflammatory diseases and cancer. Aberrant expression of TLR4 in tumors is closely associated with tumorigenesis, progression, and drug resistance. TLR4 inhibitors show promise in cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)