期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 49, 页码 45404-45415出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b15774
关键词
tumor therapy; immunomodulation; noncrystalline selenium; dendritic mesoporous silica nanoparticles; in situ synthesis
资金
- National Key Research and Development Program of China [2017YFB0702602]
- National Natural Science Foundation of China [51772316, 51602334]
- Key Project of International Cooperation and Exchange of NSFC [81720108023]
- Key Program for Basic Research of Shanghai [19JC1415600]
Developing versatile nanomaterials has offered a myriad of opportunities to surmount cancer. In particular, the combination of therapy and immunomodulatory effect to further enhance immune response provides a new idea for effective tumor treatment. Herein, for the first time, an in situ growth strategy is developed to construct highly dispersed noncrystalline selenium nanoparticles (Se NPs) with thiolated cyclo(Arg-Gly-Asp-Phe-Lys-(mpa)) (RGD) peptide modification (R-Se@DMSND) for targeted cancer treatment. Se NPs could be homogeneously grown into the pore channels of dendritic mesoporous silica nanoparticles (DMSNs) since the DMSNs could stabilize Se NPs to prevent their aggregations. Moreover, Se NPs could not only act as a therapeutic agent, inducing ROS overproduction, to effectively suppress primary tumor but also as an immunomodulatory agent to simultaneously inhibit the growth of secondary tumors by enhancement of the immune response, as confirmed by the in vivo results. Such the therapeutic-immunomodulatory strategy for tumorous therapy combining with immunomodulation using one simple nanoplatform may pave a new avenue in the biomedical field.
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