期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1861, 期 8, 页码 900-912出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2016.01.015
关键词
ERMES; ERMIONE; MICOS; MCS; Membrane contact sites; Evolutionary cell biology
资金
- European Molecular Biology Organization (EMBO) Long-term Fellowship - European Commission (EMBOCOFUND) from Marie Curie Actions [ALTF 761-2014, GA-2012-600394]
- Killam Pre-doctoral Scholarship
The ER-mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis. ERMES and MICOS are two scaffolding complexes of ERMIONE that contribute to these processes. ERMES is ancient but has been lost in several lineages including animals, plants, and SAR (stramenopiles, alveolates and rhizaria). On the other hand, MICOS is ancient and has remained present in all organisms bearing mitochondrial cristae. The ERMIONE precursor evolved in the alpha-proteobacterial ancestor of mitochondria which had the central subunit of MICOS, Mic60. The subsequent evolution of ERMIONE and its interactors in eukaryotes reflects the integrative co-evolution of mitochondria and their hosts and the adaptive paths that some lineages have followed in their specialization to certain environments. By approaching the ERMIONE from a perspective of comparative evolutionary cell biology, we hope to shed light on not only its evolutionary history, but also how ERMIONE components may function in organisms other than S. cerevisiae. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. (C) 2016 Elsevier B.V. All rights reserved.
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