期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1861, 期 8, 页码 812-829出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.03.013
关键词
Lipid domains; Lipid imaging; Perfringolysin O; Lysenin; Equinatoxin II; Aegerolysin
资金
- integrated lipidology project of RIKEN
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23770135, 60342747, 25293015]
- Grants-in-Aid for Scientific Research [23770135, 25293015] Funding Source: KAKEN
Although sphingomyelin and cholesterol are major lipids of mammalian cells, the detailed distribution of these lipids in cellular membranes remains still obscure. However, the recent development of protein probes that specifically bind sphingomyelin and/or cholesterol provides new information about the landscape of the lipid domains that are enriched with sphingomyelin or cholesterol or both. Here, we critically summarize the tools to study distribution and dynamics of sphingomyelin and cholesterol. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. (C) 2016 Elsevier B.V. All rights reserved.
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