期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 50, 页码 46497-46503出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16270
关键词
proapoptotic peptide; mesoporous silica nanoparticles (MSNs); double-load and -response; breast tumor; drug delivery
资金
- National Natural Science Foundation of China [51602334]
- Nanjing Program for Development of Medical Science and Technology, China
A material that possesses high loading efficiency (in terms of delivering small molecular drugs, nucleic acids, peptides, and proteins) has various medical applications, such as in tumor diagnosis and gene therapy or chemotherapy of tumors. Mesoporous silica nanoparticles are ideal nanocarriers for constructing drug delivery systems because of the unique mesoporous channels for encapsulation and the sustainable release of anticancer drugs. Herein, we demonstrate a doxorubicin (DOX)-peptides double-loaded and -response nanodrug (DMK nanoplatforms) as a multifunctional nanoplatform for chemotherapy of tumors. The nanoparticles are prepared by a surface modification strategy. The KLAK and DOX release in an acidic/reductive tumor microenvironment, which efficiently penetrate cell nuclei and generate the antitumor effect. Our study provides a new approach for developing a smart drug delivery nanosystem, particularly for peptides-guided pH-sensitive chemotherapy.
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