期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 50, 页码 46637-46644出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b18807
关键词
manganese-fullerenes; core-shell nanostructure; glutathione-activatable; magnetic resonance; fluorescence; bimodal imaging
资金
- National Science Foundation of China [81872813]
- State Project for Essential Drug Research and Development [2017ZX09301075]
- Outstanding Youth Fund of Jiangsu Province of China [BK20190029]
- Program of State Key Laboratory of Natural Medicines-China Pharmaceutical University [SKLNMZZCX201826]
- 111 project [B16046]
Metallofullerenes have attracted considerable attention as potential novel noninvasive high-relaxivity magnetic resonance contrast agents. However, the applications of metallofullerenes as stimuli-responsive biosensors to monitor biological processes are still scarce. Herein, manganese-fullerenes core-shell nanocomposites are prepared via a facile one-pot approach to achieve GSH-activatable magnetic resonance/fluorescence bimodal imaging functions. The nanocomposites initially have a FRET-induced quenched fluorescence, and water-resisting stimulated low T-1-MRI contrast. Upon exposure to GSH, collapse of the outer MnO2 shell led to reconstruction of the nanoprobes and subsequently resulted in multicolor fluorescence recovery and longitudinal (T-1) relaxivity enhancement (r(1) value up to 29.8 mM(-1) s(-1) at 0.5 T based on Mn ion). Our work demonstrates feasibility of using fullerenes to fabricate activatable probes for molecular imaging of GSH, which may promote the development of new fullerene-based stimuli-responsive multimodal probes for the detection and regulation of particular biological processes in vivo.
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