期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1861, 期 7, 页码 566-583出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.03.004
关键词
HDL; Cholesterol efflux; Lipid transfer proteins; Cholesterol excretion; Reverse cholesterol transport
资金
- Aarne Koskelo Foundation
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III [FIS 12-00291]
Whereas LDL-derived cholesterol accumulates in atherosclerotic lesions, HDL particles are thought to facilitate removal of cholesterol from the lesions back to the liver thereby promoting its fecal excretion from the body. Because generation of cholesterol-loaded macrophages is inherent to atherogenesis, studies on the mechanisms stimulating the release of cholesterol from these cells and its ultimate excretion into feces are crucial to learn how to prevent lesion development or even induce lesion regression. Modulation of this key anti-atherogenic pathway, known as the macrophage-specific reverse cholesterol transport, has been extensively studied in several mouse models with the ultimate aim of applying the emerging knowledge to humans. The present review provides a detailed comparison and critical analysis of the various steps of reverse cholesterol transport in mouse and man. We attempt to translate this in vivo complex scenario into practical concepts, which could serve as valuable tools when developing novel HDL-targeted therapies. (C) 2016 Elsevier B.V. All rights reserved.
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