期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 43, 页码 40704-40715出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16054
关键词
tumor microenvironment; polyprodrugs; chemotherapy; phototherapy; multimodal imaging
资金
- Major State Basic Research Development Program of China [2017YFA0205201, 2018YFA0107301]
- National Natural Science Foundation of China [51703187, 31671037]
- Basic and Frontier Research Project of Chongqing [cstc2018jcyjAX0104]
Anticancer nanomedicine-based multimodal imaging and synergistic therapy hold great promise in cancer diagnosis and therapy owing to their abilities to improve therapeutic efficiency and reduce unnecessary side effects, producing promising clinical prospects. Herein, we integrated chemotherapeutic drug camptothecin (CPT) and near-infrared-absorbing new indocyanine green (IR820) into a single system by charge interaction and obtained a tumor-microenvironment-activatable PCPTSS/IR820 nanoreactor to perform thermal/fluorescence/photoacoustic-imaging-guided chemotherapy and photothermal therapy simultaneously. Specifically, the generated PCPTSS/IR820 showed an excellent therapeutic agent loading content and size stability, and the trials in vitro and in vivo suggested that the smart PCPTSS/IR820 could deeply permeate into tumor tissues due to its suitable micellar size. Upon near-infrared laser irradiation, the nanoreactor further produced a terrific synergism of chemophoto treatment for cancer therapy. Therefore, the PCPTSS/IR820 polyprodrug-based nanoreactor holds outstanding promise for multimodal imaging and combined dual therapy.
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